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D-Index & Metrics

Chemistry

D-Index
46
Citations
9458
World Ranking
15900
National Ranking
3977

Overview

Christopher Hulme is affiliated with the University of Arizona in the United States. Their research primarily spans the fields of Materials Science and Chemistry, with notable subfields in Materials Chemistry, Organic Chemistry, and Molecular Biology. Additional areas of study include Mechanical Engineering and Public Health, Environmental and Occupational Health.

The scientist's work covers a diverse range of topics, including:

  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Down syndrome and intellectual disability research
  • Chemical Synthesis and Analysis
  • SARS-CoV-2 and COVID-19 Research
  • Multicomponent Synthesis of Heterocycles
  • Oxidative Organic Chemistry Reactions

Several recent papers authored or coauthored by Christopher Hulme are:

  • The Omnipresence of DYRK1A in Human Diseases, 2022, International Journal of Molecular Sciences
  • DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner, 2023, PLoS Biology
  • Six-Component Reactions and Beyond: The Nuts and Bolts, 2022, European Journal of Organic Chemistry
  • 5-Endo Trig Oxidative Radical Cyclizations of Ugi-3CR Products toward 1,4-Imidazolidinones, 2020, Organic Letters
  • Sequential Knoevenagel [4+1] Cycloaddition-Condensation-Aza-Friedel-Crafts Intramolecular Cyclization: A 4-Center-3-Component Reaction Toward Tunable Fluorescent Indolizine Tetracycles, 2021, The Journal of Organic Chemistry

Christopher Hulme frequently collaborates with several coauthors, including:

  • Christopher Foley (11 publications)
  • Kevin Schofield (8 publications)
  • John C. Jewett (7 publications)
  • Abigail J. Shepard (6 publications)
  • Julia A. Townsend (6 publications)

The scientist has published extensively in specific venues, with multiple contributions including:

  • The Cambridge Structural Database (8 publications)
  • Organic Letters (2 publications)
  • Tetrahedron Letters (2 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • Cancer Research (2 publications)

Best Publications

  • Maximizing Synthetic Efficiency: Multi-Component Transformations Lead the Way

    Hugues Bienaymé;Chris Hulme;Gilles Oddon;Philippe Schmitt

  • "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

    Christopher Hulme;Vijay Gore

  • New 4-point pharmacophore method for molecular similarity and diversity applications: overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures.

    Jonathan S. Mason;Isabelle Morize;Paul R. Menard;Daniel L. Cheney

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

    Arduino A. Mangoni;Catherine Guillou;Jean Jacques Vanden Eynde;Christopher Hulme

  • The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796.

    Justin Dietrich;Christopher Hulme;Laurence H. Hurley

  • Hypervalent Iodine Chemistry: New Oxidation Reactions Using the Iodosylbenzene−Trimethylsilyl Azide Reagent Combination. Direct α- and β-Azido Functionalization of Triisopropylsilyl Enol Ethers

    Philip Magnus;Jérôme Lacour;P. Andrew Evans;and Michael B. Roe

  • Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase

    Paul Joseph Cox;Shelley Bower;David John Aldous;Peter Charles Astles

  • NOVEL APPLICATIONS OF ETHYL GLYOXALATE WITH THE UGI MCR

    Christopher Hulme;M.-P. Cherrier

  • The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: Novel application of Armstrong's convertible isonitrile.

    Christopher Hulme;Matthew M. Morrissette;Francis A. Volz;Christopher J. Burns

  • Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

    Breland Smith;Federico Medda;Vijay Gokhale;Travis Dunckley

  • Novel safety-catch linker and its application with a Ugi/De-BOC/Cyclization (UDC) strategy to access carboxylic acids, 1,4-benzodiazepines, diketopiperazines, ketopiperazines and dihydroquinoxalinones

    Christopher Hulme;John Peng;George Morton;Joseph M. Salvino

  • Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry

    Christopher Hulme;Justin Dietrich

  • Improved Procedure for the Solution Phase Preparation of 1,4-Benzodiazepine-2,5-dione Libraries via Armstrong's Convertible Isonitrile and the Ugi Reaction

    Christopher Hulme;John Peng;Sheng Yuh Tang;Christopher J. Burns

  • Ugi/aldol sequence: expeditious entry to several families of densely substituted nitrogen heterocycles.

    Zhigang Xu;Fabio De Moliner;Alexandra P. Cappelli;Christopher Hulme

  • Dyrk1 inhibition improves Alzheimer's disease-like pathology

    Caterina Branca;Darren M. Shaw;Ramona Belfiore;Ramona Belfiore;Vijay Gokhale

  • Two-step solution-phase synthesis of novel benzimidazoles utilizing a UDC (Ugi/de-Boc/cyclize) strategy

    Paul Tempest;Vu Ma;Samuel Thomas;Zheng Hua

  • Emerging approaches for the syntheses of bicyclic imidazo[1,2-x]-heterocycles

    Christopher Hulme;Yeon Sun Lee

  • Alpha-Azidonation of Amides, Carbamates, and Ureas with the Iodosylbenzene/Trimethylsilyl Azide Reagent Combination - N-Acyliminium Ion Precursors

    Philip Magnus;Christopher Hulme;Wolfgang Weber

  • Two-step solution-phase synthesis of novel quinoxalinones utilizing a UDC (Ugi/de-Boc/cyclize) strategy

    Thomas Nixey;Paul Tempest;Christopher Hulme

  • MCC/SNAr methodology. Part 1: Novel access to a range of heterocyclic cores

    Paul Tempest;Vu Ma;Michael G Kelly;Wyeth Jones

Frequent Co-Authors

Philip Magnus
Philip Magnus The University of Texas at Austin
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Jack E. Baldwin
Jack E. Baldwin University of Oxford
Mark H. Norman
Mark H. Norman Amgen (Canada)
Vincent M. Lynch
Vincent M. Lynch The University of Texas at Austin
Alexander Dömling
Alexander Dömling Palacký University, Olomouc
Jérôme Lacour
Jérôme Lacour University of Geneva
Timothy D. W. Claridge
Timothy D. W. Claridge University of Oxford
Rafik Karaman
Rafik Karaman Al-Quds University
Salvatore Oddo
Salvatore Oddo Arizona State University

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