World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
43827
World Ranking
1968
National Ranking
1073

Overview

José C. Fernández-Checa is affiliated with the University of Southern California in the United States. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with significant contributions to several subfields including molecular biology, epidemiology, hepatology, surgery, and cancer research.

Their work extensively covers topics related to liver disease diagnosis and treatment, sphingolipid metabolism and signaling, cancer, lipids, and metabolism, peroxisome proliferator-activated receptors, lysosomal storage disorders research, metabolism and genetic disorders, and liver disease and transplantation.

Selected recent publications include:

  • Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis, 2020, Gut
  • STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway, 2021, Journal of Hepatology
  • Sphingomyelinases and Liver Diseases, 2020, Biomolecules
  • MITOCHONDRIAL CHOLESTEROL AND CANCER, 2020, Seminars in Cancer Biology
  • Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome, 2021, Cellular and Molecular Gastroenterology and Hepatology

Frequently collaborating coauthors include Carmen García-Ruiz, Sandra Torres, Susana Núñez, Estel Solsona-Vilarrasa, and Laura Conde de la Rosa.

Their research has been published most often in the following journals:

  • Journal of Hepatology
  • Exploration of Digestive Diseases
  • Gut
  • Seminars in Cancer Biology
  • Redox Biology

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Mitochondrial glutathione, a key survival antioxidant.

    Montserrat Marí;Albert Morales;Anna Colell;Carmen García-Ruiz

  • Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species ROLE OF MITOCHONDRIAL GLUTATHIONE

    Carmen García-Ruiz;Anna Colell;Montserrat Marí;Albert Morales

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

    Montserrat Marí;Francisco Caballero;Anna Colell;Albert Morales

  • Glutathione and mitochondria.

    Vicent Ribas;Carmen García-Ruiz;Carmen García-Ruiz;José C. Fernández-Checa;José C. Fernández-Checa

  • GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect

    J. C. Fernandez-Checa;N. Kaplowitz;C. Garcia-Ruiz;A. Colell

  • Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

    Anna Colell;Carmen García-Ruiz;Merce Miranda;Esther Ardite

  • Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.

    Francisco Caballero;Anna Fernández;Antonio M. De Lacy;Jose C. Fernández-Checa

  • Hepatic mitochondrial glutathione: transport and role in disease and toxicity

    Jose C. Fernandez-Checa;Neil Kaplowitz

  • Sphingolipids and cell death

    Albert Morales;Hyunmi Lee;Felix M. Goñi;Richard Kolesnick

  • Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma

    Joan Montero;Albert Morales;Laura Llacuna;Josep M. Lluis

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis IMPACT ON MITOCHONDRIAL S-ADENOSYL-l-METHIONINE AND GLUTATHIONE

    Francisco Caballero;Anna Fernández;Nuria Matías;Laura Martínez

  • Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation

    Carmen García-Ruiz;Anna Colell;Raquel París;J. C. Fernández-Checa

  • Defective TNF-α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice

    Carmen García-Ruiz;Anna Colell;Montserrat Marí;Albert Morales

  • Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.

    J C Fernández-Checa;C García-Ruiz;M Ookhtens;N Kaplowitz

  • VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis.

    Miquel Sans;Julián Panés;Esther Ardite;J.Ignasi Elizalde

  • Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes.

    Carmen García-Ruiz;Albert Morales;Antonio Ballesta;Joan Rodés

Frequent Co-Authors

Albert Morales
Albert Morales Spanish National Research Council
Anna Colell
Anna Colell Spanish National Research Council
Montserrat Marí
Montserrat Marí Institute of Biomedical Research of Barcelona
Neil Kaplowitz
Neil Kaplowitz University of Southern California
Carlos Enrich
Carlos Enrich University of Barcelona
Boris Zhivotovsky
Boris Zhivotovsky Karolinska Institute
Hidekazu Tsukamoto
Hidekazu Tsukamoto University of Southern California
Evelina Gatti
Evelina Gatti Aix-Marseille University
Sergio Lavandero
Sergio Lavandero University of Chile
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing José C. Fernández-Checa

Trending Scientists