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Medicine

D-Index
120
Citations
47151
World Ranking
3784
National Ranking
2078

Overview

Craig J. McClain is affiliated with the University of Louisville in the United States. Their research spans multiple disciplines within medicine and biochemistry, with a focus on liver disease, metabolism, and related health effects.

Their main fields of study include Medicine and Biochemistry, Genetics and Molecular Biology. Subfields of specialization cover Epidemiology, Pathology and Forensic Medicine, Molecular Biology, Hepatology, and Physiology.

McClain's research topics largely concentrate on areas such as Liver Disease Diagnosis and Treatment, Alcohol Consumption and Health Effects, Diet, Metabolism, and Disease, Liver Disease and Transplantation, Eicosanoids and Hypertension Pharmacology, and Gut Microbiota and Health.

Frequent co-authors collaborating with McClain are:

  • Irina Kirpich
  • Josiah Hardesty
  • Dennis Warner
  • Wenke Feng
  • Vatsalya Vatsalya

McClain's work has appeared regularly in several scientific journals. They have a notable number of publications in the following venues:

  • Gastroenterology (27 publications)
  • The FASEB Journal (20 publications)
  • Hepatology (13 publications)
  • The American Journal of Gastroenterology (12 publications)
  • Hepatology Communications (10 publications)

Recent publications by McClain include:

  • "High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance," 2021, Nature Communications
  • "Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12," 2021, Molecular Therapy
  • "IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis," 2022, Hepatology
  • "Metabolic dysfunction and alcohol-related liver disease (MetALD): Position statement by an expert panel on alcohol-related liver disease," 2024, Journal of Hepatology
  • "Restoring Oat Nanoparticles Mediated Brain Memory Function of Mice Fed Alcohol by Sorting Inflammatory Dectin-1 Complex Into Microglial Exosomes," 2021, Small

Best Publications

  • Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients

    Alexander Khoruts;Laura Stahnke;Craig J. McClain;George Logan

  • Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin.

    Ina Bergheim;Synia Weber;Miriam Vos;Sigrid Krämer

  • Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

    Yun Teng;Yi Ren;Mohammed Sayed;Xin Hu

  • Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment.

    Lara Bull-Otterson;Wenke Feng;Irina Kirpich;Yuhua Wang

  • Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study

    Irina A. Kirpich;Natalia V. Solovieva;Svetlana N. Leikhter;Natalia A. Shidakova

  • Cytokines in alcoholic liver disease.

    Craig J. McClain;Shirish Barve;Ion Deaciuc;Marcelo Kugelmas

  • Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy.

    P. Akerman;P. Cote;Shi Qi Yang;C. Mcclain

  • Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

    Akshata Moghe;Smita Ghare;Bryan Lamoreau;Mohammad Mohammad

  • Green Tea Polyphenols Block Endotoxin-Induced Tumor Necrosis Factor-Production and Lethality in a Murine Model

    Fajun Yang;Willem J. S. de Villiers;Craig J. McClain;Gary W. Varilek

  • Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes.

    Swati Joshi-Barve;Shirish S. Barve;Kiranmayi Amancherla;Leila Gobejishvili

  • Abnormal zinc metabolism in type II diabetes mellitus

    William B. Kinlaw;Allen S. Levine;John E. Morley;Stephen E. Silvis

  • Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia

    David W. Crabb;Ramon Bataller;Naga P. Chalasani;Patrick S. Kamath

  • The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6.

    Fajun Yang;Helieh S. Oz;Shirish Barve;Shirish Barve;Willem J. S. de Villiers

  • Cytokines and Alcoholic Liver Disease

    Craig McClain;Daniell Hill;Jack Schmidt;Anna Mae Diehl

  • Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition

    Matthew Cave;Ion Deaciuc;Christian Mendez;Zhenyuan Song

  • Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury.

    Thomas H. Frazier;John K. DiBaise;Craig J. McClain;Craig J. McClain

  • Ginger-derived nanoparticles protect against alcohol-induced liver damage

    Xiaoying Zhuang;Zhong-Bin Deng;Jingyao Mu;Lifeng Zhang

  • Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death.

    E J Kasarskis;S Berryman;J G Vanderleest;A R Schneider

  • A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Etanercept in the Treatment of Alcoholic Hepatitis

    Nicholas C. Boetticher;Craig J. Peine;Paul Kwo;Gary A. Abrams

  • Cytokines and metabolic dysfunction after severe head injury

    Linda Ott;Craig J. McCLAIN;Mark Gillespie;Byron Young

Frequent Co-Authors

Shirish Barve
Shirish Barve University of Louisville
Xiang Zhang
Xiang Zhang University of Louisville
Bernhard Hennig
Bernhard Hennig University of Kentucky
Huang-Ge Zhang
Huang-Ge Zhang University of Louisville
Gyongyi Szabo
Gyongyi Szabo Beth Israel Deaconess Medical Center
Ariel E. Feldstein
Ariel E. Feldstein University of California, San Diego
Melanie L. Schwandt
Melanie L. Schwandt National Institutes of Health
Timothy R. Morgan
Timothy R. Morgan California State University, Long Beach
Xiaokun Li
Xiaokun Li Wenzhou Medical University
Jun Yan
Jun Yan University of Louisville

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