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Immunology

D-Index
79
Citations
21620
World Ranking
1694
National Ranking
835

Overview

Jun Yan is a researcher affiliated with the University of Louisville in the United States, focusing primarily on topics within biochemistry, genetics, molecular biology, immunology, and medicine. Their body of work encompasses both fundamental and applied research across several closely related disciplines.

The main fields of study associated with Jun Yan include:

  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology
  • Medicine

Within these areas, their subfields of study highlight a focus on immunology, molecular biology, oncology, organic chemistry, and infectious diseases.

  • Immunology
  • Molecular Biology
  • Oncology
  • Organic Chemistry
  • Infectious Diseases

Jun Yan's research has addressed topics concerning immune cells in cancer, extracellular vesicles in disease, immune cell function and interaction, immunotherapy and immune responses, cancer immunotherapy and biomarkers, COVID-19 clinical research, and T-cell and B-cell immunology.

  • Immune cells in cancer
  • Extracellular vesicles in disease
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • COVID-19 Clinical Research Studies
  • T-cell and B-cell Immunology

Recent publications by Jun Yan demonstrate a strong engagement with cellular metabolism, immune microenvironments, and molecular mechanisms related to disease progression. Notable papers include:

  • Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming, 2021, Cell Metabolism
  • High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance, 2021, Nature Communications
  • Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12, 2021, Molecular Therapy
  • Lactate supports a metabolic-epigenetic link in macrophage polarization, 2021, Science Advances
  • Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer, 2020, Journal of Clinical Investigation

Jun Yan frequently collaborates with a group of co-authors who have participated extensively in joint research efforts. Among the most frequent co-authors are Xiao Hu, Chuanlin Ding, Huang-Ge Zhang, Anne E. Geller, and Xiang Zhang.

  • Xiao Hu
  • Chuanlin Ding
  • Huang-Ge Zhang
  • Anne E. Geller
  • Xiang Zhang

Their research is also disseminated regularly in a range of scientific journals and publication venues that focus on immunology, molecular biology, and related biomedical sciences. Most common venues include Nature Communications, Journal for ImmunoTherapy of Cancer, Theranostics, iScience, and bioRxiv (Cold Spring Harbor Laboratory).

  • Nature Communications
  • Journal for ImmunoTherapy of Cancer
  • Theranostics
  • iScience
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.

    Yihua Cai;Xiaoyan Shen;Chuanlin Ding;Chunjian Qi

  • Correction: Corrigendum: Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation

    Yihua Cai;Feng Xue;Chris Fleming;Jie Yang

  • γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer

    Pin Wu;Dang Wu;Chao Ni;Jun Ye

  • Mechanism by Which Orally Administered -1,3-Glucans Enhance the Tumoricidal Activity of Antitumor Monoclonal Antibodies in Murine Tumor Models 1

    Feng Hong;Jun Yan;Jarek T. Baran;Daniel J. Allendorf

  • Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit

    Baomei Wang;Xiaoying Zhuang;Zhong Bin Deng;Hong Jiang

  • Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.

    Samantha M. Morrissey;Fan Zhang;Chuanlin Ding;Diego Elias Montoya-Durango

  • Memory CD4 + T cells do not induce graft-versus-host disease

    Britt E. Anderson;Jennifer McNiff;Jun Yan;Hester Doyle

  • MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

    Yun Teng;Yi Ren;Xin Hu;Xin Hu;Jingyao Mu

  • Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

    Qilong Wang;Xiaoying Zhuang;Jingyao Mu;Zhong-Bin Deng

  • New insights of T cells in the pathogenesis of psoriasis

    Yihua Cai;Chris Fleming;Jun Yan

  • Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase

    Zhongbin Deng;Yuan Rong;Yun Teng;Jingyao Mu

  • The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells.

    Xia Y;Vetvicka;Yan J;Hanikýrová M

  • Therapeutic intervention with complement and β-glucan in cancer

    Gordon D Ross;Václav Větvička;Jun Yan;Yu Xia

  • Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites

    Qilong Wang;Yi Ren;Jingyao Mu;Nejat K. Egilmez

  • Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived β-glucans

    Chunjian Qi;Chunjian Qi;Yihua Cai;Lacey Gunn;Chuanlin Ding

  • A Critical Role of the IL-1β–IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis

    Yihua Cai;Feng Xue;Chen Quan;Minye Qu

  • Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses.

    Fang Ting Liang;Jun Yan;M. Lamine Mbow;Steven L. Sviat

  • High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance

    Anil Kumar;Kumaran Sundaram;Jingyao Mu;Gerald W. Dryden

  • IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection

    Tian Wang;Eileen Scully;Zhinan Yin;Jung H. Kim

  • Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18).

    Jun Yan;V. Vetvicka;Yu Xia;A. Coxon

  • Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells.

    Feng Hong;Richard D. Hansen;Jun Yan;Daniel J. Allendorf

  • Yeast β-Glucan Amplifies Phagocyte Killing of iC3b-Opsonized Tumor Cells via Complement Receptor 3-Syk-Phosphatidylinositol 3-Kinase Pathway

    Bing Li;Daniel J. Allendorf;Richard Hansen;Jose Marroquin

Frequent Co-Authors

Huang-Ge Zhang
Huang-Ge Zhang University of Louisville
Donald R. Miller
Donald R. Miller University of Louisville
Suzanne T. Ildstad
Suzanne T. Ildstad University of Louisville
Teresa W.-M. Fan
Teresa W.-M. Fan University of Kentucky
Andrew N. Lane
Andrew N. Lane University of Kentucky
Mariusz Z. Ratajczak
Mariusz Z. Ratajczak University of Louisville
Xiang Zhang
Xiang Zhang University of Louisville
Richard M. Higashi
Richard M. Higashi University of Kentucky
Mark J. Mamula
Mark J. Mamula Yale University
Daniel W. Cramer
Daniel W. Cramer Brigham and Women's Hospital

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