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D-Index & Metrics

Immunology

D-Index
48
Citations
9023
World Ranking
4431
National Ranking
2011

Overview

Mark J. Mamula is affiliated with Yale University in the United States. Their research primarily focuses on medicine, with significant contributions in biochemistry, genetics, molecular biology, immunology, and microbiology. Mamula's subfields of study include genetics, immunology, surgery, endocrinology, diabetes, metabolism, and oncology.

The scientist's main research topics revolve around diabetes and associated disorders, pancreatic function and diabetes, diabetes management and research, immune cell function and interaction, T-cell and B-cell immunology, cancer immunotherapy and biomarkers, as well as pancreatic and hepatic oncology research.

Recent publications by Mark J. Mamula illustrate a strong focus on autoimmune and inflammatory aspects of diabetes and related diseases. Notable papers include:

  • Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis (2021, Science Advances)
  • The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes (2021, Frontiers in Endocrinology)
  • Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes (2022, JCI Insight)
  • Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology (2021, Frontiers in Immunology)
  • Citrullination of glucokinase is linked to autoimmune diabetes (2022, Nature Communications)

Frequent co-authors collaborating with Mamula include:

  • Mei-Ling Yang
  • Eddie A. James
  • Renelle J. Gee
  • Kevan C. Herold
  • Carmella Evans-Molina

Publication venues where Mamula has frequently published are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Diabetes
  • Science Advances
  • Frontiers in Endocrinology

Mark J. Mamula's body of work integrates immunology and metabolic research approaches, particularly focusing on the pathology and immunological mechanisms underlying type 1 diabetes and related autoimmune diseases. Their contributions span experimental research on immune cell interactions with pancreatic beta cells, as well as molecular mechanisms such as protein citrullination affecting autoimmune responses.

Best Publications

  • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

    Christina M. Lau;Courtney Broughton;Abigail S. Tabor;Shizuo Akira

  • From T to B and back again: positive feedback in systemic autoimmune disease.

    Mark J. Shlomchik;Joseph E. Craft;Mark J. Mamula

  • Memory CD4 + T cells do not induce graft-versus-host disease

    Britt E. Anderson;Jennifer McNiff;Jun Yan;Hester Doyle

  • Post-translational protein modifications in antigen recognition and autoimmunity

    Hester A Doyle;Mark J Mamula

  • Induction of autoreactive B cells allows priming of autoreactive T cells.

    Rong Hwa Lin;Mark J. Mamula;John A. Hardin;Charles A. Janeway

  • B cells process and present lupus autoantigens that initiate autoimmune T cell responses

    M J Mamula;S Fatenejad;J Craft

  • Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins.

    Mark J. Mamula;Renelle J. Gee;James I. Elliott;Alessandro Sette

  • Do B cells drive the diversification of immune responses

    Mark J. Mamula;Charles A. Janeway

  • Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses.

    Fang Ting Liang;Jun Yan;M. Lamine Mbow;Steven L. Sviat

  • IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection

    Tian Wang;Eileen Scully;Zhinan Yin;Jung H. Kim

  • Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c.

    M. J. Mamula;Rong-Hwa Lin;C. A. Janeway;J. A. Hardin

  • Autoantigenesis: the evolution of protein modifications in autoimmune disease.

    Hester A Doyle;Mark J Mamula

  • The inability to process a self-peptide allows autoreactive T cells to escape tolerance.

    M J Mamula

  • Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes

    Mark J. Mamula

  • Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles

    Saeed Fatenejad;Mark J. Mamula;Joe Craft

  • Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens

    Sandra Santulli-Marotto;Marc W Retter;Renelle Gee;Mark J Mamula

  • Self-peptides in the initiation of lupus autoimmunity.

    L K Bockenstedt;R J Gee;M J Mamula

  • Posttranslational Modifications of Self‐Antigens

    Hester A. Doyle;Mark J. Mamula

  • Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States.

    Peter J. Krause;Sukanya Narasimhan;Gary P. Wormser;Alan G. Barbour

  • B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation

    Jun Yan;Bohdan P. Harvey;Renelle J. Gee;Mark J. Shlomchik

Frequent Co-Authors

Joe Craft
Joe Craft Yale University
Jun Yan
Jun Yan University of Louisville
Kevan C. Herold
Kevan C. Herold Yale University
Steven Clarke
Steven Clarke University of California, Los Angeles
Eddie A. James
Eddie A. James Virginia Mason Medical Center
Mark J. Shlomchik
Mark J. Shlomchik University of Pittsburgh
John A. Hardin
John A. Hardin Albert Einstein College of Medicine
Decio L. Eizirik
Decio L. Eizirik Université Libre de Bruxelles
Erol Fikrig
Erol Fikrig Yale University
Charles A. Janeway
Charles A. Janeway Yale University

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