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Microbiology

D-Index
71
Citations
21081
World Ranking
1818
National Ranking
776

Overview

Livia Casciola-Rosen is affiliated with Johns Hopkins University School of Medicine in the United States and has contributed extensively to the field of medicine, particularly within rheumatology and immunology. Their research predominantly focuses on inflammatory and autoimmune disorders, including inflammatory myopathies and dermatomyositis.

Their work encompasses a broad range of subfields, such as epidemiology, pathology and forensic medicine, gastroenterology, and dermatological and skeletal disorders. The concentrations within their research topics are specifically notable for inflammatory myopathies and dermatomyositis, systemic sclerosis and related diseases, eosinophilic disorders and syndromes, celiac disease management, immunodeficiency and autoimmune disorders, and systemic lupus erythematosus research.

Among recent significant publications authored or co-authored by Casciola-Rosen are:

  • "Study of Tofacitinib in Refractory Dermatomyositis: An Open-Label Pilot Study of Ten Patients" (2020, Arthritis & Rheumatology)
  • "Performance of the 2017 European Alliance of Associations for Rheumatology/American College of Rheumatology Classification Criteria for Idiopathic Inflammatory Myopathies in Patients With Myositis-Specific Autoantibodies" (2021, Arthritis & Rheumatology)
  • "Immune responses to CCAR1 and other dermatomyositis autoantigens are associated with attenuated cancer emergence" (2022, Journal of Clinical Investigation)
  • "The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps" (2022, eLife)
  • "IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function" (2022, JCI Insight)

Casciola-Rosen frequently publishes in venues such as Arthritis & Rheumatology, bioRxiv (Cold Spring Harbor Laboratory), ACR Open Rheumatology, and Annals of the Rheumatic Diseases, reflecting a strong presence in rheumatology and immunology research communities.

Collaborations form an important part of Casciola-Rosen's research contributions, with frequent co-authors including Antony Rosen, Christopher A. Mecoli, Ami A. Shah, Laura Gutierrez-Alamillo, and Lisa Christopher-Stine. These collaborations have supported a diversified research output spanning clinical and translational studies.

Best Publications

  • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

    L A Casciola-Rosen;G Anhalt;A Rosen

  • Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

    Livia Casciola-Rosen;Donald W. Nicholson;Tae Chong;Kevin R. Rowan

  • Autoantibodies against 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase in patients with statin‐associated autoimmune myopathy

    Andrew L Mammen;Tae Chung;Lisa Christopher-Stine;Paul Rosen

  • Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity

    Livia Casciola-Rosen;Felipe Andrade;Danielle Ulanet;Wes Bang Wong

  • Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus.

    Livia Casciola-Rosen;Antony Rosen;Michelle Petri;Mark Schlissel

  • The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): A retrospective study

    David Fiorentino;Lorinda Chung;Jeff Zwerner;Antony Rosen

  • A novel autoantibody recognizing 200‐kd and 100‐kd proteins is associated with an immune‐mediated necrotizing myopathy

    Lisa Christopher-Stine;Livia A. Casciola-Rosen;Grace Hong;Tae Chung

  • The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

    Marie Mancini;Donald W. Nicholson;Sophie Roy;Nancy A. Thornberry

  • DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

    Livia A. Casciola-Rosen;Grant J. Anhalt;Antony Rosen

  • Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

    Livia A. Casciola-Rosen;Douglas K. Miller;Grant J. Anhalt;Antony Rosen

  • Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

    Marie Mancini;Carolyn E. Machamer;Sophie Roy;Donald W. Nicholson

  • Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer

    Christine G. Joseph;Erika Darrah;Ami A. Shah;Andrew D. Skora

  • Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

    Felipe Andrade;Sophie Roy;Donald Nicholson;Nancy Thornberry

  • Ufd2, a Novel Autoantigen in Scleroderma, Regulates Sister Chromatid Separation

    Sarah Spinette;Christoph Lengauer;James A. Mahoney;Prasad V. Jallepalli

  • Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy

    Livia Casciola-Rosen;Kanneboyina Nagaraju;Paul Plotz;Kondi Wang

  • Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

    Antony Rosen;Livia Casciola-Rosen

  • Most Patients With Cancer-Associated Dermatomyositis Have Antibodies to Nuclear Matrix Protein NXP-2 or Transcription Intermediary Factor 1γ

    David F. Fiorentino;Lorinda S. Chung;Lisa Christopher-Stine;Lisa Zaba

  • Activation of the endoplasmic reticulum stress response in autoimmune myositis: Potential role in muscle fiber damage and dysfunction

    Kanneboyina Nagaraju;Livia Casciola-Rosen;Ingrid Lundberg;Rashmi Rawat

  • Histidyl–tRNA Synthetase and Asparaginyl–tRNA Synthetase, Autoantigens in Myositis, Activate Chemokine Receptors on T Lymphocytes and Immature Dendritic Cells

    O.M. Zack Howard;Hui Fang Dong;De Yang;Nina Raben

  • Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum.

    John C. Hall;Livia Casciola-Rosen;Lesly Ann Samedy;Jessie Werner

  • Novel packages of viral and self-antigens are generated during apoptosis.

    Antony Rosen;Livia Casciola-Rosen;Joseph Ahearn

Frequent Co-Authors

Antony Rosen
Antony Rosen Johns Hopkins University School of Medicine
Fredrick M. Wigley
Fredrick M. Wigley Johns Hopkins University
Michelle Petri
Michelle Petri Johns Hopkins University School of Medicine
Nancy A. Thornberry
Nancy A. Thornberry MSD (United States)
Stephen J. Elledge
Stephen J. Elledge Harvard University
Paul H. Plotz
Paul H. Plotz National Institutes of Health
Donald W. Nicholson
Donald W. Nicholson MSD (United States)
Nina Raben
Nina Raben National Institutes of Health
Ann Louise Hubbard
Ann Louise Hubbard Johns Hopkins University School of Medicine
Grant James Anhalt
Grant James Anhalt Johns Hopkins University

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