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Nancy A. Thornberry

Nancy A. Thornberry

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
57224
World Ranking
3977
National Ranking
1960

Overview

Nancy A. Thornberry is affiliated with MSD (United States) and has contributed to the fields of Medicine and Neuroscience. Their research spans several subfields including Nutrition and Dietetics, Endocrine and Autonomic Systems, Surgery, Oncology, and Endocrinology, Diabetes and Metabolism.

The scientist's work is focused on topics such as Biochemical Analysis and Sensing Techniques, Regulation of Appetite and Obesity, Pancreatic Function and Diabetes, Peptidase Inhibition and Analysis, Diabetes Treatment and Management, and Neuropeptides and Animal Physiology.

Recent publications by Nancy A. Thornberry include the following papers:

  • The gut-brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders (2021), Molecular Metabolism
  • Dipeptidyl Peptidase 4 Inhibitors (2021), Burger's Medicinal Chemistry and Drug Discovery

Frequent coauthors in their research include:

  • Paul Richards
  • Shirly Pinto
  • Ann E. Weber

The research outputs have appeared primarily in the following venues:

  • Molecular Metabolism
  • Burger's Medicinal Chemistry and Drug Discovery

Best Publications

  • Caspases: Enemies Within

    Nancy A. Thornberry;Yuri Lazebnik

  • Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

    D W Nicholson;A Ali;N A Thornberry;J P Vaillancourt

  • Caspases: killer proteases

    Donald W. Nicholson;Nancy A. Thornberry

  • Human ICE/CED-3 Protease Nomenclature

    Emad S Alnemri;David J Livingston;Donald W Nicholson;Guy Salvesen

  • A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.

    Nancy A. Thornberry;Herbert G. Bull;Jimmy R. Calaycay;Kevin T. Chapman

  • A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B FUNCTIONAL RELATIONSHIPS ESTABLISHED FOR KEY MEDIATORS OF APOPTOSIS

    Nancy A. Thornberry;Thomas A. Rano;Erin P. Peterson;Dita M. Rasper

  • Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors

    Margarita Garcia-Calvo;Erin P. Peterson;Barbara Leiting;Rejean Ruel

  • (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

    Dooseop Kim;Liping Wang;Maria Beconi;George J. Eiermann

  • Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

    François G. Gervais;Daigen Xu;George S. Robertson;John P. Vaillancourt

  • The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

    Margarita Garcia-Calvo;JeanMarie Lisnock;Herbert G. Bull;Brian E. Hawes

  • Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.

    Y.P. Goldberg;D.W. Nicholson;D.M. Rasper;M.A. Kalchman

  • Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

    Livia Casciola-Rosen;Donald W. Nicholson;Tae Chong;Kevin R. Rowan

  • Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

    Cheryl L. Wellington;Lisa M. Ellerby;Abigail S. Hackam;Russell L. Margolis

  • CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis.

    Jörg Schlegel;Iris Peters;Sten Orrenius;Douglas K. Miller

  • CASPASES : KEY MEDIATORS OF APOPTOSIS

    Nancy A. Thornberry

  • Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes: Potential Importance of Selectivity Over Dipeptidyl Peptidases 8 and 9

    George R. Lankas;Barbara Leiting;Ranabir Sinha Roy;George J. Eiermann

  • Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic β-Cell Mass and Function in a Rodent Model of Type 2 Diabetes

    James Mu;John Woods;Yun-Ping Zhou;Ranabir Sinha Roy

  • The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.

    Jennifer Rotonda;Donald W. Nicholson;Kimberly M. Fazil;Michel Gallant

  • Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

    Alessandro Pocai;Paul E. Carrington;Jennifer R. Adams;Michael Wright

  • The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

    Marie Mancini;Donald W. Nicholson;Sophie Roy;Nancy A. Thornberry

Frequent Co-Authors

Ann E. Weber
Ann E. Weber MSD (United States)
Donald W. Nicholson
Donald W. Nicholson MSD (United States)
Kevin T. Chapman
Kevin T. Chapman MSD (United States)
Andrew D. Howard
Andrew D. Howard MSD (United States)
Giovanna Scapin
Giovanna Scapin MSD (United States)
Sophie Roy
Sophie Roy MSD (United States)
Malcolm Maccoss
Malcolm Maccoss MSD (United States)
Antony Rosen
Antony Rosen Johns Hopkins University School of Medicine
Arthur A. Patchett
Arthur A. Patchett MSD (United States)
Livia Casciola-Rosen
Livia Casciola-Rosen Johns Hopkins University School of Medicine

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