Sophie Roy

Overview

Best Publications

• A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B FUNCTIONAL RELATIONSHIPS ESTABLISHED FOR KEY MEDIATORS OF APOPTOSIS

  Nancy A. Thornberry;Thomas A. Rano;Erin P. Peterson;Dita M. Rasper

  3227
  Citations

• Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

  François G. Gervais;Daigen Xu;George S. Robertson;John P. Vaillancourt

  1016
  Citations

• Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

  Rona K. Graham;Yu Deng;Elizabeth J. Slow;Brendan Haigh

  819
  Citations

• Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.

  Antonis E. Koromilas;Sophie Roy;Glen N. Barber;Michael G. Katze

  771
  Citations

• Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte.

  R. S. Hotchkiss;K. C. Chang;P. E. Swanson;K. W. Tinsley

  751
  Citations

• Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

  Vanessa S. Marsden;Liam O'Connor;Liam O'Connor;Lorraine A. O'Reilly;John Silke

  722
  Citations

• Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

  Cheryl L. Wellington;Lisa M. Ellerby;Abigail S. Hackam;Russell L. Margolis

  712
  Citations

• The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

  Marie Mancini;Donald W. Nicholson;Sophie Roy;Nancy A. Thornberry

  566
  Citations

• A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.

  S. Roy;U. Delling;Chein-Hwa Chen;C. A. Rosen

  551
  Citations

• Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

  Maya Saleh;John P. Vaillancourt;Rona K. Graham;Matthew Huyck

  530
  Citations

• Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

  Marie Mancini;Carolyn E. Machamer;Sophie Roy;Donald W. Nicholson

  502
  Citations

• Caspase Cleavage of Mutant Huntingtin Precedes Neurodegeneration in Huntington's Disease

  Cheryl L. Wellington;Lisa M. Ellerby;Claire-Anne Gutekunst;Danny Rogers

  495
  Citations

• Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

  Felipe Andrade;Sophie Roy;Donald Nicholson;Nancy Thornberry

  463
  Citations

• Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.

  Cheryl L. Wellington;Roshni Singaraja;Lisa Ellerby;Jane Savill

  462
  Citations

• Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.

  Dita M. Rasper;John P. Vaillancourt;Shinji Hadano;Shinji Hadano;Vicky M. Houtzager

  452
  Citations

• Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

  François G. Gervais;Roshni Singaraja;Steven Xanthoudakis;Claire-Anne Gutekunst

  408
  Citations

• Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis

  Steven Xanthoudakis;Sophie Roy;Dita Rasper;Trevor Hennessey

  402
  Citations

• Cross-Talk in Cell Death Signaling

  Sophie Roy;Donald W. Nicholson

  347
  Citations

• Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.

  François G. Gervais;Nancy A. Thornberry;Salvatore C. Ruffolo;Donald W. Nicholson

  280
  Citations

• Maintenance of caspase-3 proenzyme dormancy by an intrinsic “safety catch” regulatory tripeptide

  Sophie Roy;Christopher I. Bayly;Yves Gareau;Vicky M. Houtzager

  261
  Citations