World's Best Scientists 2026 revealed!

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Microbiology

D-Index
86
Citations
23106
World Ranking
849
National Ranking
52

Medicine

D-Index
86
Citations
23107
World Ranking
14278
National Ranking
755

Overview

Otto Haller is a researcher affiliated with the University of Freiburg in Germany. Their work spans multiple disciplines within the life sciences, with a focus on the intersection of molecular biology, immunology, and epidemiology.

Their publication record includes research centered on influenza virus studies, immune responses mediated by interferons, and conditions related to diabetes. These topics represent the core of their scientific investigations.

  • Influenza Virus Research Studies
  • interferon and immune responses
  • Diabetes and associated disorders

Otto Haller's research fields encompass Medicine; Immunology and Microbiology; and Biochemistry, Genetics and Molecular Biology. Within these broad areas, their subfield expertise includes Epidemiology, Immunology, and Genetics.

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

  • Epidemiology
  • Immunology
  • Genetics

Their scientific output has been published in the journal Science, indicating contributions to high-impact, peer-reviewed literature. A notable paper published in 2021 is titled Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus, which connects genetic variation with infectious disease susceptibility.

  • Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus (2021, Science)

Throughout their career, Haller has collaborated with a number of researchers, contributing to interdisciplinary approaches within their projects. Frequent coauthors include Yongkun Chen, Laura Graf, Tao Chen, Qijun Liao, and Tian Bai.

  • Yongkun Chen
  • Laura Graf
  • Tao Chen
  • Qijun Liao
  • Tian Bai

Best Publications

  • The interferon response circuit: Induction and suppression by pathogenic viruses

    Otto Haller;Georg Kochs;Friedemann Weber

  • Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity.

    Otto Haller;Georg Kochs

  • Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts

    R. Kiessling;R. Kiessling;Paula S. Hochman;O. Haller;G. M. Shearer

  • Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein.

    J Pavlovic;T Zürcher;O Haller;P Staeheli

  • Genetic Evidence for an Interferon-Antagonistic Function of Rift Valley Fever Virus Nonstructural Protein NSs

    Michèle Bouloy;Christian Janzen;Pierre Vialat;Huot Khun

  • Mx GTPases: dynamin-like antiviral machines of innate immunity

    Otto Haller;Peter Staeheli;Martin Schwemmle;Georg Kochs

  • Interferon-induced Mx proteins in antiviral host defense.

    Otto Haller;Peter Staeheli;Georg Kochs

  • NSs Protein of Rift Valley Fever Virus Blocks Interferon Production by Inhibiting Host Gene Transcription

    Agnès Billecocq;Martin Spiegel;Pierre Vialat;Alain Kohl

  • Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.

    Otto Haller;Georg Kochs

  • Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle.

    J Pavlovic;O Haller;P Staeheli

  • Interferon-γ inhibits replication of subgenomic and genomic hepatitis C virus RNAs☆

    Michael Frese;Verena Schwärzle;Kerstin Barth;Nicole Krieger

  • Mx proteins: mediators of innate resistance to RNA viruses.

    O Haller;M Frese;G Kochs

  • Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation.

    P Staeheli;R Grob;E Meier;J G Sutcliffe

  • Role of non-conventional natural killer cells in resistance against syngeneic tumour cells in vivo

    O. Haller;M. Hansson;R. Kiessling;H. Wigzell

  • Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3

    Martin Spiegel;Andreas Pichlmair;Luis Martínez-Sobrido;Jerome Cros

  • Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus.

    M A Horisberger;P Staeheli;O Haller

  • Structural basis of oligomerization in the stalk region of dynamin-like MxA.

    Song Gao;Song Gao;Alexander von der Malsburg;Susann Paeschke;Joachim Behlke

  • Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein.

    Michael Frese;Georg Kochs;Heinz Feldmann;Christian Hertkorn

  • Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes

    Georg Kochs;Christian Janzen;Heinz Hohenberg;Otto Haller

  • Inverse interference: how viruses fight the interferon system.

    Friedemann Weber;Georg Kochs;Otto Haller

  • Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon Signaling

    Dirk Holzinger;Carl Jorns;Silke Stertz;Stéphanie Boisson-Dupuis

Frequent Co-Authors

Peter Deplazes
Peter Deplazes University of Zurich
Rolf M. Zinkernagel
Rolf M. Zinkernagel University of Zurich
Johannes Eckert
Johannes Eckert University of Zurich
Georg Kochs
Georg Kochs University of Freiburg
Peter Staeheli
Peter Staeheli University of Freiburg
Friedemann Weber
Friedemann Weber University of Giessen
Michael Frese
Michael Frese Asia School of Business
Martin Schwemmle
Martin Schwemmle University of Freiburg
Erik C. Böttger
Erik C. Böttger University of Zurich
Heinz Arnheiter
Heinz Arnheiter National Institutes of Health

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