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D-Index & Metrics

Chemistry

D-Index
49
Citations
9957
World Ranking
14720
National Ranking
3762

Overview

Robert Zamboni is affiliated with MSD (United States) and conducts research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Clinical Biochemistry, Genetics, Cancer Research, and Nephrology.

The research topics explored by Robert Zamboni focus on mitochondrial function and pathology, metabolism and genetic disorders, cancer related to hypoxia and metabolism, genetic syndromes and imprinting, parathyroid disorders and treatments, genetic and kidney cyst diseases, and studies in biochemical acid research.

Their recent publications include:

  • Pathogenic mitochondrial dysfunction and metabolic abnormalities (2021), published in Biochemical Pharmacology
  • Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs (2020), published in BioResearch open access
  • Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury (2022), published in Biochemical Pharmacology
  • PORT-77, a Novel and Potent Inhibitor of ABCG2, Protects Against Skin Photo Toxicity and Liver Damage in a Mouse Model of Erythropoietic Protoporphyria (EPP) (2024), published in Blood

Frequent co-authors in their publications include Walter H. Moos, Douglas V. Faller, Ioannis P. Glavas, David N. Harpp, and Iphigenia Kanara.

The venues where Robert Zamboni most frequently publishes include Biochemical Pharmacology, BioResearch open access, and Blood.

Best Publications

  • Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

    François G. Gervais;Daigen Xu;George S. Robertson;John P. Vaillancourt

  • Etoricoxib (MK-0663): Preclinical Profile and Comparison with Other Agents That Selectively Inhibit Cyclooxygenase-2

    D Riendeau;M D Percival;C Brideau;S Charleson

  • The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

    P Prasit;Z Wang;C Brideau;C.-C Chan

  • The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

    Jacques Yves Gauthier;Nathalie Chauret;Wanda Cromlish;Sylvie Desmarais

  • Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.

    D Riendeau;M D Percival;S Boyce;C Brideau

  • Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.

    T. R. Jones;R. Zamboni;M. Belley;E. Champion

  • Purification and catalytic properties of human caspase family members.

    Margarita Garcia-Calvo;Erin P Peterson;Dita M Rasper;John P Vaillancourt

  • Practical Route to a New Class of LTD4 Receptor Antagonists

    Robert D. Larsen;Edward G. Corley;Anthony O. King;James D. Carroll

  • Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates.

    Jaimie F Borisoff;Carmen C.M Chan;Gordon W Hiebert;Loren Oschipok

  • Selective, Reversible Caspase-3 Inhibitor Is Neuroprotective and Reveals Distinct Pathways of Cell Death after Neonatal Hypoxic-ischemic Brain Injury

    Byung Hee Han;Daigen Xu;Junjeong Choi;Yongxin Han

  • Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase.

    J F Evans;D J Nathaniel;R J Zamboni;A W Ford-Hutchinson

  • Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

    Donald W. Nicholson;Ambereen Ali;John P. Vaillancourt;Jimmy R. Calaycay

  • Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

    W. Cameron Black;Christopher I. Bayly;Dana E. Davis;Sylvie Desmarais

  • Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K

    Unknown

  • Discovery of MK-0476, a potent and orally active leukotriene D4 receptor antagonist devoid of peroxisomal enxyme induction

    M. Labelle;M. Belley;Y. Gareau;J.Y. Gauthier

  • Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis

    Joseph W Becker;Jennifer Rotonda;Stephen M Soisson;Renee Aspiotis

  • Comparative biological activities of synthetic leukotriene b4 and its ω-oxidation products

    A.W. Ford-Hutchinson;A. Rackham;R. Zamboni;J. Rokach

  • The stereospecific synthesis of leukotriene A4 (LTA4), 5-epi-LTA4, 6-epi-LTA4 and 5-epi,6-epi-LTA4

    Joshua Rokach;Robert Zamboni;Cheuk-Kun Lau;Yvan Guindon

  • Affinity selection from peptide libraries to determine substrate specificity of protein tyrosine phosphatases.

    Gregory Huyer;Gregory Huyer;John Kelly;Jason Moffat;Robert Zamboni

  • The development of sensitive and specific radioimmunoassays for leukotrienes

    J. Rokach;E.C. Hayes;Y. Girard;D.L. Lombardo

  • 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors.

    J F Evans;C Lévillé;J A Mancini;P Prasit

Frequent Co-Authors

Robert N. Young
Robert N. Young Simon Fraser University
Anthony W. Ford-Hutchinson
Anthony W. Ford-Hutchinson Independent Scientist / Consultant, US
Joshua Rokach
Joshua Rokach Florida Institute of Technology
Donald W. Nicholson
Donald W. Nicholson MSD (United States)
Denis Riendeau
Denis Riendeau MSD (United States)
Sophie Roy
Sophie Roy MSD (United States)
Nancy A. Thornberry
Nancy A. Thornberry MSD (United States)
Joseph A. Mancini
Joseph A. Mancini MSD (United States)
Michael J. Therien
Michael J. Therien Duke University

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