World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
113
Citations
36324
World Ranking
874
National Ranking
547

Medicine

D-Index
113
Citations
36353
World Ranking
5021
National Ranking
2721

Research.com Recognitions

  • 1998 - Warren Alpert Foundation Prize For elucidating the pathway forming the leukotrienes and their role in bronchial asthma.
  • 1991 - Member of the National Academy of Medicine (NAM)
  • 1987 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1977 - Canada Gairdner International Award
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

K. Frank Austen was affiliated with Brigham and Women's Hospital in the United States. Their research primarily focused on medicine and immunology, with particular emphasis on asthma and respiratory diseases, mast cells and histamine, and immune system pathways involving IL-33, ST2, and ILC. Other topics included allergic rhinitis and sensitization, immune cell function and interaction, T-cell and B-cell immunology, as well as dermatology and skin diseases.

The scientist's work was published across several respected venues, reflecting a broad engagement with immunology and related fields. Notable journals featuring their work included:

  • Nature Immunology
  • Theranostics
  • Proceedings of the National Academy of Sciences
  • The Journal of Experimental Medicine
  • Journal of Allergy and Clinical Immunology

Austen coauthored frequently with other researchers, indicating active collaboration in multidisciplinary studies. Some of their most common coauthors were:

  • Daniel F. Dwyer
  • Evgeny Kiner
  • Brinda Vijaykumar
  • Kaitavjeet Chowdhary
  • Sara Mostafavi

The scientist contributed to at least five substantial papers in recent years, including:

  • "Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes," 2021, Nature Immunology
  • "Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts," 2020, Theranostics
  • "The CysLT 2 R receptor mediates leukotriene C 4 -driven acute and chronic itch," 2021, Proceedings of the National Academy of Sciences
  • "Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation," 2020, The Journal of Experimental Medicine
  • "Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference," 2021, Journal of Allergy and Clinical Immunology

Austen received several recognitions over their career, including:

  • Warren Alpert Foundation Prize in 1998 for elucidating the pathway forming leukotrienes and their role in bronchial asthma
  • Member of the National Academy of Medicine since 1991
  • Fellow of the American Association for the Advancement of Science since 1987
  • Canada Gairdner International Award in 1977
  • Member of the Association of American Physicians

Best Publications

  • Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases.

    Robert A. Lewis;K. Frank Austen;Roy J. Soberman

  • Diagnostic criteria and classification of mastocytosis: a consensus proposal

    Peter Valent;Hans P. Horny;Luis Escribano;B. Jack Longley

  • Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human Skin

    Nicholas A. Soter;Nicholas A. Soter;Robert A. Lewis;Robert A. Lewis;E.J. Corey;E.J. Corey;K. Frank Austen;K. Frank Austen

  • Contaminated heparin associated with adverse clinical events and activation of the contact system.

    Takashi Kei Kishimoto;Karthik Viswanathan;Tanmoy Ganguly;Subbiah Elankumaran

  • Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds.

    Robert A. Lewis;K. Frank Austen

  • Immunological release of histamine and slow reacting substance of anaphylaxis from human lung.

    Michael Kaliner;Robert P. Orange;K. Frank Austen

  • Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources

    Robert A. Lewis;K. Frank Austen;Jeffrey M. Drazen;David A. Clark

  • The structure of normal skin and the morphology of atopic eczema.

    Martin C Mihm;Nicholas A Soter;Harold F Dvorak;K Frank Austen

  • A PREALBUMIN ACTIVATOR OF PREKALLIKREIN : II. DERIVATION OF ACTIVATORS OF PREKALLIKREIN FROM ACTIVE HAGEMAN FACTOR BY DIGESTION WITH PLASMIN

    Allen P. Kaplan;K. Frank Austen

  • Recent advances in the cellular and molecular biology of mast cells

    Richard L. Stevens;K. Frank Austen

  • Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis

    Yojiro Arinobu;Hiromi Iwasaki;Hiromi Iwasaki;Michael F. Gurish;Shin Ichi Mizuno

  • Developmental origin and functional specialization of mast cell subsets.

    Michael F. Gurish;K. Frank Austen

  • Immunological release of histamine and slow-reacting substance of anaphylaxis from human lung : I. Modulation by agents influencing cellular levels of cyclic 3',5'-adenosine monophosphate.

    Robert P. Orange;W. Gerald Austen;K. Frank Austen

  • Immunologic Release of β-Hexosaminidase and β-Glucuronidase from Purified Rat Serosal Mast Cells

    Lawrence B. Schwartz;K. Frank Austen;Stephen I. Wasserman

  • Exercise-induced anaphylaxis

    Albert L. Sheffer;K.Frank Austen

  • Identification of the C(6)-S-conjugate of leukotriene a with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity

    Robert A. Lewis;Jeffrey M. Drazen;K.Frank Austen;David A. Clark

  • Expression profiling of constitutive mast cells reveals a unique identity within the immune system

    Daniel F Dwyer;Daniel F Dwyer;Nora A Barrett;Nora A Barrett;K Frank Austen;K Frank Austen

  • AN EOSINOPHIL LEUKOCYTE CHEMOTACTIC FACTOR OF ANAPHYLAXIS

    A. B. Kay;Daniel J. Stechschulte;K. Frank Austen

  • Intestinal Mast Cell Progenitors Require CD49dβ7 (α4β7 Integrin) for Tissue-specific Homing

    Michael F. Gurish;Hong Tao;J. Pablo Abonia;Anu Arya

  • Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells

    Nora A. Barrett;Akiko Maekawa;Opu M. Rahman;K. Frank Austen

Frequent Co-Authors

Yoshihide Kanaoka
Yoshihide Kanaoka Brigham and Women's Hospital
Robert A. Lewis
Robert A. Lewis University of California, San Francisco
Michael F. Gurish
Michael F. Gurish Harvard Medical School
Daniel S. Friend
Daniel S. Friend Brigham and Women's Hospital
Douglas T. Fearon
Douglas T. Fearon Cold Spring Harbor Laboratory
Joshua A. Boyce
Joshua A. Boyce Brigham and Women's Hospital
Stephen I. Wasserman
Stephen I. Wasserman University of California, San Diego
Richard L. Stevens
Richard L. Stevens Brigham and Women's Hospital
E. J. Corey
E. J. Corey Harvard University
Jonathan P. Arm
Jonathan P. Arm Novartis (Switzerland)

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