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Immunology

D-Index
107
Citations
56296
World Ranking
540
National Ranking
325

Medicine

D-Index
108
Citations
57265
World Ranking
5906
National Ranking
3166

Research.com Recognitions

  • 2001 - Member of the National Academy of Sciences
  • 1999 - Fellow of the Royal Society, United Kingdom
  • 1999 - Fellow of the American Academy of Arts and Sciences
  • 1990 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the Association of American Physicians
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the Association of American Physicians
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the Association of American Physicians
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the Association of American Physicians
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Douglas T. Fearon is affiliated with Cold Spring Harbor Laboratory in the United States. Their research focuses on multiple areas within medicine, immunology and microbiology, and biochemistry, genetics and molecular biology, with particular emphasis on immunology, oncology, molecular biology, cell biology, and epidemiology.

The scientist's work covers several major topics including immunotherapy and immune responses, CAR-T cell therapy research, immune cell function and interaction, cancer immunotherapy and biomarkers, single-cell and spatial transcriptomics, T-cell and B-cell immunology, and pancreatic and hepatic oncology research.

Douglas T. Fearon has published extensively in a range of venues. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Nature, The Journal of Immunology, and Nature Reviews Cancer.

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Nature
  • The Journal of Immunology
  • Nature reviews. Cancer

Notable recent publications include:

  • A framework for advancing our understanding of cancer-associated fibroblasts, 2020, Nature Reviews Cancer
  • Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I, 2020, Nature
  • CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response, 2020, Proceedings of the National Academy of Sciences
  • Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack, 2022, Apollo (University of Cambridge)
  • Cancer cell CCR2 orchestrates suppression of the adaptive immune response, 2020, The Journal of Experimental Medicine

They collaborate frequently with several coauthors, including Philip Moresco (9 publications), Tobias Janowitz (6 publications), Zhikai Wang (6 publications), David A. Tuveson (5 publications), and Ran Yan (5 publications).

Douglas T. Fearon has received multiple recognitions, including:

  • Member of the National Academy of Sciences, 2001
  • Fellow of the Royal Society, United Kingdom, 1999
  • Fellow of the American Academy of Arts and Sciences, 1999
  • Fellow of the American Association for the Advancement of Science (AAAS), 1990
  • Member of the Association of American Physicians
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom

Best Publications

  • A framework for advancing our understanding of cancer-associated fibroblasts

    Erik Sahai;Igor Astsaturov;Edna Cukierman;David G. DeNardo

  • The instructive role of innate immunity in the acquired immune response.

    Douglas T. Fearon;Richard M. Locksley

  • T cell exclusion, immune privilege, and the tumor microenvironment

    Johanna A. Joyce;Douglas T. Fearon;Douglas T. Fearon

  • Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

    Daniel Öhlund;Daniel Öhlund;Daniel Öhlund;Abram Handly-Santana;Abram Handly-Santana;Giulia Biffi;Giulia Biffi;Ela Elyada;Ela Elyada

  • Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.

    Christine Feig;James O. Jones;Matthew Kraman;Richard J. B. Wells

  • C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

    Paul W. Dempsey;Michael E. D. Allison;Srinivas Akkaraju;Christopher C. Goodnow

  • Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.

    Jean Albrengues;Mario Anthonio Shields;David Ng;Chun Gwon Park

  • Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2.

    J D Fingeroth;J J Weis;T F Tedder;J L Strominger

  • Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α

    Matthew Kraman;Paul J. Bambrough;James N. Arnold;Edward W. Roberts

  • Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis

    Harlan F. Weisman;Thomas Bartow;Michelle K. Leppo;Henry C. Marsh

  • Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

    Vinod P. Balachandran;Marta Łuksza;Julia N. Zhao;Vladimir Makarov

  • Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

    Keisuke Yamamoto;Anthony Venida;Julian Yano;Douglas E. Biancur

  • Distinct fibroblast subsets drive inflammation and damage in arthritis.

    Adam P. Croft;Joana Campos;Kathrin Jansen;Jason D. Turner

  • Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte.

    DT Fearon

  • CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes

    Robert H. Carter;Douglas T. Fearon

  • Control of the amplification convertase of complement by the plasma protein beta1H.

    J M Weiler;M R Daha;K F Austen;D T Fearon

  • Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system.

    A Nicholson-Weller;J Burge;D T Fearon;P F Weller

  • Epstein-Barr Virus gp350/220 Binding to the B Lymphocyte C3d Receptor Mediates Adsorption, Capping, and Endocytosis

    Jerome Tanner;Janis Weis;Janis Weis;Douglas Fearon;Douglas Fearon;Young Whang

  • A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

    G. M. Doody;L. B. Justement;C. C. Delibrias;R. J. Matthews

  • Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex.

    Douglas T. Fearon;Michael C. Carroll

  • Structure and Function of the Complement Receptors, CR1 (CD35) and CR2 (CD21)

    Joseph M. Ahearn;Douglas T. Fearon

Frequent Co-Authors

K. Frank Austen
K. Frank Austen Brigham and Women's Hospital
David A. Tuveson
David A. Tuveson Cold Spring Harbor Laboratory
Janis J. Weis
Janis J. Weis University of Utah
Christopher D. Buckley
Christopher D. Buckley University of Oxford
Andrew Filer
Andrew Filer University of Birmingham
Thomas F. Tedder
Thomas F. Tedder Duke University
Mohamed R. Daha
Mohamed R. Daha Leiden University
John A. Smith
John A. Smith University of Alabama at Birmingham
Mikala Egeblad
Mikala Egeblad Cold Spring Harbor Laboratory
Francis D. Moore
Francis D. Moore Brigham and Women's Hospital

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For accelerated advancement, considering one of the accelerated nurse practitioner programs can fast-track your education and career. These programs are designed for motivated students and professionals seeking to enter or advance quickly within healthcare roles linked to Immunology.

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