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Immunology

D-Index
68
Citations
18902
World Ranking
2570
National Ranking
227

Overview

Andrew Filer is affiliated with the University of Birmingham in the United Kingdom, with a primary research focus in Medicine. Their work spans several subfields including Rheumatology, Immunology, Molecular Biology, Hematology, and Genetics.

The main topics of Andrew Filer's research include:

  • Rheumatoid Arthritis Research and Therapies
  • Systemic Lupus Erythematosus Research
  • Autoimmune and Inflammatory Disorders Research
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Single-cell and spatial transcriptomics
  • Lymphoma Diagnosis and Treatment

Frequent co-authors collaborating with Andrew Filer are:

  • Karim Raza
  • Christopher D. Buckley
  • Soumya Raychaudhuri
  • Michael B. Brenner
  • Jennifer H. Anolik

Andrew Filer has contributed extensively to peer-reviewed journals, with prominent venues including:

  • Annals of the Rheumatic Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Lara D. Veeken
  • Nature Communications
  • Nature

Selected recent publications by Andrew Filer include:

  • Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis, 2020, Nature Medicine
  • Notch signalling drives synovial fibroblast identity and arthritis pathology, 2020, Nature
  • Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes, 2023, Nature
  • The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts, 2021, Immunity
  • Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases, 2022, Med

The volume of their publications, particularly 84 in Rheumatology and 53 in Immunology, highlights a consistent focus on immune-mediated diseases. Their work employs advanced techniques such as single-cell and spatial transcriptomics to explore pathogenic mechanisms and cellular phenotypes in chronic inflammatory conditions.

Best Publications

  • Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

    Fan Zhang;Kevin Wei;Kamil Slowikowski;Chamith Y Fonseka

  • Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

    Deepak A. Rao;Michael F. Gurish;Jennifer L. Marshall;Kamil Slowikowski

  • Distinct fibroblast subsets drive inflammation and damage in arthritis.

    Adam P. Croft;Joana Campos;Kathrin Jansen;Jason D. Turner

  • Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.

    Stefano Alivernini;Lucy MacDonald;Aziza Elmesmari;Samuel Finlay

  • Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

    Fumitaka Mizoguchi;Kamil Slowikowski;Kevin Wei;Jennifer L. Marshall

  • CD56bright Human NK Cells Differentiate Into CD56dim Cells: Role of Contact With Peripheral Fibroblasts

    Antoni Chan;Deng-Li Hong;Ann Atzberger;Simon Kollnberger

  • Notch signalling drives synovial fibroblast identity and arthritis pathology

    Kevin Wei;Ilya Korsunsky;Jennifer L. Marshall;Anqi Gao

  • A stromal address code defined by fibroblasts.

    Greg Parsonage;Andrew D. Filer;Oliver Haworth;Gerard B. Nash

  • Altered Expression of MicroRNA-203 in Rheumatoid Arthritis Synovial Fibroblasts and Its Role in Fibroblast Activation

    Joanna Stanczyk;Caroline Ospelt;Caroline Ospelt;Emmanuel Karouzakis;Andrew Filer

  • Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes

    Unknown

  • Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

    Alexander V. Misharin;Carla M. Cuda;Rana Saber;Jason D. Turner

  • Utility of ultrasound joint counts in the prediction of rheumatoid arthritis in patients with very early synovitis

    Andrew Filer;Paola de Pablo;Gina Allen;Peter Nightingale

  • Synovial tissue research: a state-of-the-art review

    Carl Orr;Elsa Sousa;David L Boyle;Maya H Buch

  • Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

    Julia Spengler;Božo Lugonja;A. Jimmy Ytterberg;Roman A. Zubarev

  • Fibroblasts as novel therapeutic targets in chronic inflammation.

    S J Flavell;T Z Hou;S Lax;A D Filer

  • Suppression of Inflammation in Primary Systemic Vasculitis Restores Vascular Endothelial Function: Lessons for Atherosclerotic Disease?

    K. Raza;J. Thambyrajah;J. N. Townend;A. R. Exley

  • Ultrasound-guided synovial biopsy: a safe, well-tolerated and reliable technique for obtaining high-quality synovial tissue from both large and small joints in early arthritis patients

    S Kelly;F Humby;A Filer;N Ng

  • Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

    Lorraine Yeo;Kai-Michael Toellner;Mike Salmon;Andrew Filer

  • Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis

    Mária Filková;Borbala Aradi;Ladislav Šenolt;Caroline Ospelt

  • The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.

    Jasna Friščić;Martin Böttcher;Christiane Reinwald;Heiko Bruns

  • Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort

    Mohammed Z Cader;Andrew Filer;Jonathan Hazlehurst;Paola de Pablo

  • Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: Moving toward individualized treatment decision-making

    Annette H. M. van Der Helm-van Mil;Jacqueline Detert;Saskia Le Cessie;Andrew Filer

  • Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns

    Greg Parsonage;Francesco Falciani;Angela Burman;Andrew Filer

Frequent Co-Authors

Christopher D. Buckley
Christopher D. Buckley University of Oxford
Iain B. McInnes
Iain B. McInnes University of Glasgow
Mike Salmon
Mike Salmon University of Birmingham
John D. Isaacs
John D. Isaacs Newcastle University
Gerard B. Nash
Gerard B. Nash University of Birmingham
Costantino Pitzalis
Costantino Pitzalis Queen Mary University of London
Michael B. Brenner
Michael B. Brenner Harvard Medical School
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital
Andrew R. Clark
Andrew R. Clark University of Birmingham
Harris Perlman
Harris Perlman Northwestern University

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