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Immunology

D-Index
70
Citations
12706
World Ranking
2460
National Ranking
6

Overview

Ursula Fearon is affiliated with Trinity College Dublin in Ireland. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a particular focus on Rheumatology and Immunology as key subfields. The main topics in their work include rheumatoid arthritis research and therapies, systemic lupus erythematosus research, autoimmune and inflammatory disorders research, immune cell function and interaction, T-cell and B-cell immunology, immunotherapy, and immune responses, as well as psoriasis treatment and pathogenesis.

Fearon has contributed to numerous publications, with a consistent presence in several high-profile journals. Frequent venues for their work include:

  • Annals of the Rheumatic Diseases
  • Frontiers in Immunology
  • Lara D. Veeken
  • Arthritis Research & Therapy
  • bioRxiv (Cold Spring Harbor Laboratory)

Among recent papers authored by Ursula Fearon are:

  • "MicroRNA-17-5p Reduces Inflammation and Bone Erosions in Mice With Collagen-Induced Arthritis and Directly Targets the JAK/STAT Pathway in Rheumatoid Arthritis Fibroblast-like Synoviocytes" (2020, Arthritis & Rheumatology)
  • "The PD-1:PD-L1 axis in Inflammatory Arthritis" (2021, BMC Rheumatology)
  • "Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease" (2021, Clinical & Translational Immunology)
  • "Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications" (2022, Nature Reviews Rheumatology)
  • "Serum miRNA Signature in Rheumatoid Arthritis and "At-Risk Individuals"" (2021, Frontiers in Immunology)

Their collaborative work includes frequent partnerships with other researchers. Among coauthors who have contributed extensively to shared research are:

  • Douglas J. Veale
  • Mary Canavan
  • Achilleas Floudas
  • Viviana Marzaioli
  • Megan M. Hanlon

Ursula Fearon's research contributions mainly address complex immune-mediated diseases, focusing on the molecular and cellular mechanisms underlying chronic inflammatory conditions. Their work on cellular metabolic adaptations and signaling pathways in rheumatoid arthritis integrates immunology and molecular biology approaches to explore therapeutic implications.

Best Publications

  • The role of metabolism in the pathogenesis of osteoarthritis

    Ali Mobasheri;Ali Mobasheri;Margaret P. Rayman;Oreste Gualillo;Jérémie Sellam

  • Hypoxia, oxidative stress and inflammation

    Trudy McGarry;Monika Biniecka;Douglas J. Veale;Ursula Fearon

  • The pathogenesis of psoriatic arthritis.

    Douglas J Veale;Ursula Fearon;Ursula Fearon

  • Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis.

    Ursula Fearon;Mary Canavan;Monika Biniecka;Douglas J. Veale

  • Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

    Simon Rauber;Markus Luber;Stefanie Weber;Lisa Maul

  • Angiopoietins, growth factors, and vascular morphology in early arthritis.

    Ursula Fearon;Konstantina Griosios;Alexander Fraser;Richard Reece

  • Synovial tissue hypoxia and inflammation in vivo

    C T Ng;M Biniecka;A Kennedy;J McCormick

  • Synovial tissue research: a state-of-the-art review

    Carl Orr;Elsa Sousa;David L Boyle;Maya H Buch

  • Dysregulated bioenergetics: a key regulator of joint inflammation

    M Biniecka;M Canavan;T McGarry;W Gao

  • Macrophages in synovial inflammation.

    Aisling Kennedy;Ursula Fearon;Douglas J. Veale;Catherine Godson

  • Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis

    Wei Gao;Jennifer McCormick;Mary Connolly;Emese Balogh

  • Angiogenesis and blood vessel stability in inflammatory arthritis.

    Aisling Kennedy;Chin Teck Ng;Monika Biniecka;Tajvur Saber

  • Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells.

    Sharee A. Basdeo;Deborah Cluxton;Jamal Sulaimani;Barry Moran

  • Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors

    W Gao;T McGarry;C Orr;J McCormick

  • Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies

    Ellen M Moran;Ronan Mullan;Jennifer McCormick;Mary Connolly

  • Hypoxia Activates NF-κB–Dependent Gene Expression Through the Canonical Signaling Pathway

    Kathryn M. Oliver;John F. Garvey;Chin Teck Ng;Douglas J. Veale

  • Acute‐phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF‐κB–dependent signal transduction pathway

    Ronan H. Mullan;Barry Bresnihan;Lucy Golden-Mason;Trevor Markham

  • JAK/STAT Blockade Alters Synovial Bioenergetics, Mitochondrial Function, and Proinflammatory Mediators in Rheumatoid Arthritis.

    Trudy McGarry;Carl Orr;Sarah Wade;Monika Biniecka

  • Turnover of Type II Collagen and Aggrecan in Cartilage Matrix at the Onset of Inflammatory Arthritis in Humans Relationship to Mediators of Systemic and Local Inflammation

    Alexander Fraser;Ursula Fearon;R. Clark Billinghurst;Mirela Ionescu

  • The Utility and Limitations of CRP, ESR and DAS28-CRP in Appraising Disease Activity in Rheumatoid Arthritis.

    Carl K. Orr;Aurelie Najm;Francis Young;Trudy McGarry

  • Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers.

    Barry Bresnihan;Eliza Pontifex;Rogier M. Thurlings;Marjolein Vinkenoog

Frequent Co-Authors

Douglas J. Veale
Douglas J. Veale University College Dublin
Oliver FitzGerald
Oliver FitzGerald University College Dublin
Barry Bresnihan
Barry Bresnihan University College Dublin
Paul Emery
Paul Emery University of Leeds
John D. Isaacs
John D. Isaacs Newcastle University
Danielle M. Gerlag
Danielle M. Gerlag UCB Pharma (United Kingdom)
Paul P. Tak
Paul P. Tak GlaxoSmithKline (United Kingdom)
Costantino Pitzalis
Costantino Pitzalis Queen Mary University of London
Zoltán Szekanecz
Zoltán Szekanecz University of Debrecen
Anthony G. Wilson
Anthony G. Wilson University College Dublin

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