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Genetics

D-Index
61
Citations
30341
World Ranking
3015
National Ranking
15

Overview

Michael L. Frigge is affiliated with deCODE Genetics in Iceland and has contributed extensively to research in genetics, medicine, and molecular biology. Their work spans a range of topics primarily focused on pregnancy-related conditions, developmental health, and genetic mechanisms underlying various disorders.

The scientist has published in several notable venues, including:

  • Communications Biology
  • Nature Genetics
  • European Heart Journal
  • Nature Communications
  • Arthritis & Rheumatology

Among their recent papers are:

  • Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women, 2020, Nature Communications
  • A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis, 2021, Communications Biology
  • Distinction between the effects of parental and fetal genomes on fetal growth, 2021, Nature Genetics
  • Genetic insight into sick sinus syndrome, 2021, European Heart Journal
  • The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in Iceland, 2021, Arthritis & Rheumatology

Their main fields of study include Medicine and Biochemistry, Genetics and Molecular Biology, with specific subfields such as Obstetrics and Gynecology, Molecular Biology, Pediatrics, Perinatology and Child Health, Rheumatology, and Surgery.

The central research topics covered in their work are:

  • Pregnancy and preeclampsia studies
  • Birth, Development, and Health
  • Gestational Diabetes Research and Management
  • Epigenetics and DNA Methylation
  • Iron Metabolism and Disorders
  • Folate and B Vitamins Research
  • Hemoglobinopathies and Related Disorders

Michael L. Frigge has collaborated frequently with several researchers, including:

  • Daníel F. Guðbjartsson
  • Kāri Stefánsson
  • Unnur Þorsteinsdóttir
  • Guðmar Þorleifsson
  • Ingileif Jónsdóttir

Best Publications

  • Rate of de novo mutations and the importance of father’s age to disease risk

    Augustine Kong;Michael L. Frigge;Gisli Masson;Soren Besenbacher;Soren Besenbacher

  • Neuregulin 1 and Susceptibility to Schizophrenia

    Hreinn Stefansson;Engilbert Sigurdsson;Valgerdur Steinthorsdottir;Soley Bjornsdottir

  • A high-resolution recombination map of the human genome

    Augustine Kong;Daniel F. Gudbjartsson;Jesus Sainz;Gudrun M. Jonsdottir

  • The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

    Anna Helgadottir;Andrei Manolescu;Gudmar Thorleifsson;Solveig Gretarsdottir

  • Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

    Julius Gudmundsson;Patrick Sulem;Andrei Manolescu;Laufey T Amundadottir

  • Allegro, a new computer program for multipoint linkage analysis

    Daniel F. Gudbjartsson;Daniel F. Gudbjartsson;Kristjan Jonasson;Michael L. Frigge;Augustine Kong;Augustine Kong

  • A common inversion under selection in Europeans

    Hreinn Stefansson;Agnar Helgason;Gudmar Thorleifsson;Valgerdur Steinthorsdottir

  • Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.

    Simon N Stacey;Andrei Manolescu;Patrick Sulem;Thorunn Rafnar

  • Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

    Julius Gudmundsson;Patrick Sulem;Valgerdur Steinthorsdottir;Jon T. Bergthorsson

  • Some Implementations of the Boxplot

    Michael Frigge;David C. Hoaglin;Boris Iglewicz

  • The nature of nurture: Effects of parental genotypes.

    Augustine Kong;Augustine Kong;Augustine Kong;Gudmar Thorleifsson;Michael L. Frigge;Bjarni J. Vilhjalmsson;Bjarni J. Vilhjalmsson

  • Large-scale whole-genome sequencing of the Icelandic population

    Daniel F Gudbjartsson;Hannes Helgason;Sigurjon A Gudjonsson;Florian Zink

  • The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.

    Solveig Gretarsdottir;Gudmar Thorleifsson;Sigridur Th Reynisdottir;Andrei Manolescu

  • Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.

    Thorunn Rafnar;Patrick Sulem;Simon N Stacey;Frank Geller

  • Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.

    Florian Zink;Simon N. Stacey;Gudmundur L. Norddahl;Michael L. Frigge

  • Parental influence on human germline de novo mutations in 1,548 trios from Iceland

    Hákon Jónsson;Patrick Sulem;Birte Kehr;Snaedis Kristmundsdottir

  • Fine-scale recombination rate differences between sexes, populations and individuals

    Augustine Kong;Gudmar Thorleifsson;Daniel F. Gudbjartsson;Gisli Masson

  • Parental origin of sequence variants associated with complex diseases

    Augustine Kong;Valgerdur Steinthorsdottir;Gisli Masson;Gudmar Thorleifsson

  • Detection of sharing by descent, long-range phasing and haplotype imputation

    Augustine Kong;Gisli Masson;Michael L Frigge;Arnaldur Gylfason

  • Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans.

    Nancy J. Cox;Mike Frigge;Dan L. Nicolae;Dan L. Nicolae;Patrick Concannon

Frequent Co-Authors

Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)
Augustine Kong
Augustine Kong University of Oxford
Unnur Thorsteinsdottir
Unnur Thorsteinsdottir deCODE Genetics (Iceland)
Daniel F. Gudbjartsson
Daniel F. Gudbjartsson deCODE Genetics (Iceland)
Jeffrey R. Gulcher
Jeffrey R. Gulcher deCODE Genetics (Iceland)
Gudmar Thorleifsson
Gudmar Thorleifsson deCODE Genetics (Iceland)
Patrick Sulem
Patrick Sulem deCODE Genetics (Iceland)
Agnar Helgason
Agnar Helgason University of Iceland
Gisli Masson
Gisli Masson deCODE Genetics (Iceland)
Thorunn Rafnar
Thorunn Rafnar deCODE Genetics (Iceland)

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