Denis Riendeau

Overview

Best Publications

• Characterization of prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

  S Kargman;S Charleson;M Cartwright;J Frank

  703
  Citations

• Etoricoxib (MK-0663): Preclinical Profile and Comparison with Other Agents That Selectively Inhibit Cyclooxygenase-2

  D Riendeau;M D Percival;C Brideau;S Charleson

  654
  Citations

• The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

  P Prasit;Z Wang;C Brideau;C.-C Chan

  599
  Citations

• The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

  Jacques Yves Gauthier;Nathalie Chauret;Wanda Cromlish;Sylvie Desmarais

  556
  Citations

• Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.

  D Riendeau;M D Percival;S Boyce;C Brideau

  489
  Citations

• Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice

  Michael E. Burleigh;Vladimir R. Babaev;John A. Oates;Raymond C. Harris

  413
  Citations

• Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.

  D Riendeau;J Guay;P K Weech;F Laliberté

  373
  Citations

• Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.

  Daniel Dubé;Marc Blouin;Christine Brideau;Chi-Chung Chan

  366
  Citations

• Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1

  Jocelyne Guay;Kevin Bateman;Robert Gordon;Joseph Mancini

  359
  Citations

• Cloning, expression, and up-regulation of inducible rat prostaglandin E synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis

  Joseph A. Mancini;Katherine Blood;Jocelyne Guay;Robert Gordon

  343
  Citations

• Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

  David Claveau;Mirna Sirinyan;Jocelyne Guay;Robert Gordon

  266
  Citations

• Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays

  Denis Riendeau;Stella Charleson;Wanda Cromlish;Joseph A. Mancini

  255
  Citations

• Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.

  Per-Johan Jakobsson;Joseph A. Mancini;Denis Riendeau;Anthony W. Ford-Hutchinson

  237
  Citations

• MF63 {2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile}, a selective microsomal prostaglandin E synthase 1 inhibitor, relieves pyresis and pain in preclinical models of inflammation

  Daigen Xu;Steven E. Rowland;Patsy Clark;André Giroux

  213
  Citations

• Lysosomotropism of Basic Cathepsin K Inhibitors Contributes to Increased Cellular Potencies against Off-Target Cathepsins and Reduced Functional Selectivity

  Jean-Pierre Falgueyret;Sylvie Desmarais;Renata Oballa;W Cameron Black

  212
  Citations

• Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

  Denis Riendeau;Renee Aspiotis;Diane Ethier;Yves Gareau

  210
  Citations

• A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin

  Marc Ouellet;Denis Riendeau;M. David Percival

  199
  Citations

• Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

  Bernard Côté;Louise Boulet;Christine Brideau;David Claveau

  197
  Citations

• 2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors

  Richard W Friesen;Christine Brideau;Chi Chung Chan;Stella Charleson

  194
  Citations

• Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety

  Joseph A. Mancini;Denis Riendeau;Jean-Pierre Falgueyret;Philip J. Vickers

  191
  Citations