Gideon A. Rodan mainly investigates Osteoclast, Internal medicine, Endocrinology, Bone resorption and Bone remodeling. His Osteoclast study combines topics from a wide range of disciplines, such as Cancer research, Bisphosphonate, Geranylgeranylation, Cell biology and Resorption. The various areas that Gideon A. Rodan examines in his Internal medicine study include Bioinformatics and Osteoblast.
The Endocrinology study combines topics in areas such as Angiogenesis and Cycloheximide. He combines subjects such as Epiphyseal plate, Integrin, Mevalonate pathway and Membrane ruffling with his study of Bone resorption. His studies deal with areas such as Osteoarthritis, Osteoporosis, Pathology, Anterior cruciate ligament and Cartilage as well as Bone remodeling.
His primary areas of study are Internal medicine, Endocrinology, Osteoclast, Bone resorption and Cell biology. His Internal medicine study frequently links to other fields, such as Osteoblast. The concepts of his Endocrinology study are interwoven with issues in Parathyroid hormone, In vivo and Cancellous bone.
His studies in Osteoclast integrate themes in fields like Multinucleate, Cancer research, Immunology, Cytoskeleton and Extracellular matrix. His research in Bone resorption focuses on subjects like Bisphosphonate, which are connected to Farnesyl diphosphate synthase and Pharmacology. His work deals with themes such as Integrin and Podosome, which intersect with Cell biology.
Gideon A. Rodan mostly deals with In vivo, Endocrinology, Internal medicine, Biochemistry and Pharmacokinetics. In his research, Stereochemistry is intimately related to In vitro, which falls under the overarching field of In vivo. His research in Endocrinology is mostly concerned with Thermoregulation.
When carried out as part of a general Biochemistry research project, his work on Cathepsin K, Apoptosis, Prostaglandin E and Forskolin is frequently linked to work in Sphingosine kinase, therefore connecting diverse disciplines of study. His Bone resorption research is multidisciplinary, incorporating perspectives in Ovariectomized rat, Bone disease and Biomedical engineering. Gideon A. Rodan interconnects Osteoarthritis, Bisphosphonate, Anterior cruciate ligament, Cartilage and Bone remodeling in the investigation of issues within Osteoclast.
His primary scientific interests are in Bone remodeling, Bone resorption, Anatomy, Osteoclast and Bisphosphonate. Gideon A. Rodan works mostly in the field of Bone remodeling, limiting it down to topics relating to Pathology and, in certain cases, Chondrocyte. His study in Bone mineral extends to Bone resorption with its themes.
Gideon A. Rodan has included themes like Geranyltranstransferase, Mechanism of action, Prenylation, Protein prenylation and Pharmacology in his Osteoclast study. His research integrates issues of Bone disease, Drug discovery and Farnesyl diphosphate synthase in his study of Bisphosphonate. His Augment investigation overlaps with Cortical bone, Internal medicine and Endocrinology.
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Therapeutic approaches to bone diseases.
Gideon A. Rodan;T. John Martin.
Control of osteoblast function and regulation of bone mass
Shun-ichi Harada;Gideon A. Rodan.
Principles of bone biology
John P. Bilezikian;Lawrence G. Raisz;Gideon A. Rodan.
Bisphosphonates: mechanisms of action.
Gideon A. Rodan;Herbert A. Fleisch.
Journal of Clinical Investigation (1996)
Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.
Masahiko Sato;William Grasser;Naoto Endo;Robert Akins.
Journal of Clinical Investigation (1991)
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
J. E. Fisher;M. J. Rogers;J. M. Halasy;S. P. Luckman.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.
Valeria Poli;Raffaella Balena;Elena Fattori;Angelo Markatos.
The EMBO Journal (1994)
Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties.
Sevgi B. Rodan;Yasuo Imai;Mark A. Thiede;Gregg Wesolowski.
Cancer Research (1987)
The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model.
Tadashi Hayami;Maureen Pickarski;Gregg A. Wesolowski;Julia Mclane.
Arthritis & Rheumatism (2004)
Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.
Tadashi Hayami;Maureen Pickarski;Ya Zhuo;Gregg A. Wesolowski.
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