World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
55
Citations
8122
World Ranking
12404
National Ranking
30

Research.com Recognitions

  • 2008 - Fellow of the Royal Society of New Zealand
  • Fellow of the Academy of Social Sciences, United Kingdom
  • Fellow of the Academy of Social Sciences, United Kingdom
  • Fellow of the Academy of Social Sciences, United Kingdom
  • Fellow of the Academy of Social Sciences, United Kingdom
  • Fellow of the Academy of Social Sciences, United Kingdom

Overview

Peter C. Tyler is affiliated with Victoria University of Wellington in New Zealand. Their research spans several fields within biochemistry and medicine, focusing particularly on molecular biology and infectious diseases.

Their recent publications reflect work across a range of topics and journals. Notable papers include:

  • Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides, 2020, Nature Communications
  • Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues, 2021, Nature Communications
  • Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition, 2023, Journal of Biological Chemistry
  • Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases, 2022, Biochemistry
  • Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic, 2023, Biomaterials Advances

Frequent coauthors collaborating with Peter C. Tyler include:

  • Vern L. Schramm
  • Ralf Schwörer
  • Rajesh K. Harijan
  • Kajitha Suthagar
  • Karl J. Shaffer

Peter's work has been published multiple times in several venues, with prominent frequent publication venues comprising:

  • Biochemistry
  • The Cambridge Structural Database
  • Nature Communications
  • Journal of Medicinal Chemistry
  • Organic & Biomolecular Chemistry

They have contributed to the academic literature not only through journal articles but also via book publications, including a title published by Bloomsbury Academic eBooks:

  • The Living Philosophy of Edith Stein, 2022

Main fields of study covered by Peter C. Tyler's research are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these domains, their subfields of research include:

  • Molecular Biology
  • Infectious Diseases
  • Materials Chemistry
  • Cell Biology
  • Surgery

Key topics addressed in their work are:

  • HIV/AIDS drug development and treatment
  • Biochemical and Molecular Research
  • Proteoglycans and glycosaminoglycans research
  • Clostridium difficile and Clostridium perfringens research
  • Helicobacter pylori-related gastroenterology studies
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography

Peter C. Tyler has been recognized as a Fellow of the Royal Society of New Zealand since 2008 and holds fellowship status with the Academy of Social Sciences in the United Kingdom.

Best Publications

  • One-Third-the-Sites Transition-State Inhibitors for Purine Nucleoside Phosphorylase†

    Robert W. Miles;Peter C. Tyler;Richard H. Furneaux;Carey K. Bagdassarian

  • Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis

    A Fedorov;W Shi;G Kicska;E Fedorov

  • Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.

    Greg A. Kicska;Li Long;Heidi Hörig;Craig Fairchild

  • Liposomal delivery of antigen to human dendritic cells.

    Melissa J. Copland;Margaret A. Baird;Thomas Rades;Judith L. McKenzie

  • The 2.0 Å structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

    Wuxian Shi;Caroline M. Li;Peter C. Tyler;Richard H. Furneaux

  • Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli

    Vipender Singh;Gary B. Evans;Dirk H. Lenz;Jennifer M. Mason

  • Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase.

    Andrzej Lewandowicz;Peter C. Tyler;Gary B. Evans;Richard H. Furneaux

  • Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.

    Wuxian Shi;Li Min Ting;Gregory A. Kicska;Andrzej Lewandowicz

  • The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.

    Wuxian Shi;Caroline M. Li;Peter C. Tyler;Richard H. Furneaux

  • Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

    Gregory A. Kicska;Peter C. Tyler;Gary B. Evans;Richard H. Furneaux

  • Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins.

    Li Min Ting;Wuxian Shi;Andrzej Lewandowicz;Vipender Singh

  • Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases.

    Caroline M. Li;Peter C. Tyler;Richard H. Furneaux;Gregory Kicska

  • Exploring Structure−Activity Relationships of Transition State Analogues of Human Purine Nucleoside Phosphorylase

    Gary B. Evans;Richard H. Furneaux;Andrzej Lewandowicz;Vern L. Schramm

  • Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase.

    Gary B. Evans;Richard H. Furneaux;Andrzej Lewandowicz;Vern L. Schramm

  • Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum.

    Gregory A. Kicska;Peter C. Tyler;Gary B. Evans;Richard H. Furneaux

  • Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis.

    L. Gil;Yongxin Han;E. E. Opas;G. A. Rodan

  • Addition of Lithiated 9-Deazapurine Derivatives to a Carbohydrate Cyclic Imine: Convergent Synthesis of the Aza-C-nucleoside Immucillins

    Gary B. Evans;Richard H. Furneaux;Tracy L. Hutchison;Hollis S. Kezar

  • Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

    Gary B. Evans;Richard H. Furneaux;Graeme J. Gainsford;Vern L. Schramm

  • Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.

    Gary B. Evans;Richard H. Furneaux;Ben Greatrex;Andrew S. Murkin

  • Mannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells

    Karen Louise White;Thomas Rades;Richard H Furneaux;Peter C Tyler

  • Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease

    Ralf Schwörer;Olga V. Zubkova;Jeremy E. Turnbull;Peter C. Tyler

Frequent Co-Authors

Vern L. Schramm
Vern L. Schramm Albert Einstein College of Medicine
Richard H. Furneaux
Richard H. Furneaux Victoria University of Wellington
Gary B. Evans
Gary B. Evans Victoria University of Wellington
Steven C. Almo
Steven C. Almo Albert Einstein College of Medicine
Robert N. Young
Robert N. Young Simon Fraser University
Stephen Hanessian
Stephen Hanessian University of Montreal
Gideon A. Rodan
Gideon A. Rodan MSD (United States)
Kami Kim
Kami Kim University of South Florida
P. Lynne Howell
P. Lynne Howell University of Toronto
Ching C. Wang
Ching C. Wang University of California, San Francisco

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a degree in Chemistry in the USA opens doors to varied career paths, many of which can be enhanced through complementary online programs. For those interested in expanding their skill set, obtaining a criminal justice associate degree online can provide unique opportunities in regulatory compliance and safety oversight.

Additionally, professionals aiming to support legal aspects of scientific industries might consider earning a paralegal certificate. This qualification equips students with the knowledge necessary to navigate legal documentation and contracts effectively.

For those drawn to the commercial side of chemistry-related fields, working as a pharmaceutical sales representative is an appealing option. Understanding the pharma sales rep salary and career pathways helps prospective candidates evaluate this dynamic and lucrative role.

Finally, becoming a licensed pharmacist remains a top career for chemistry graduates, though it requires significant commitment. Knowing how much schooling to be a pharmacist is crucial for planning your education and future success in this demanding but rewarding profession.

Best Scientists Citing Peter C. Tyler

Trending Scientists