What is he best known for?
The fields of study he is best known for:
- Enzyme
- Organic chemistry
- Catalysis
Peter C. Tyler mainly focuses on Stereochemistry, Purine nucleoside phosphorylase, Transition state analog, Enzyme and Biochemistry.
His research integrates issues of Imine, Transferase, Carbohydrate and Oxocarbenium in his study of Stereochemistry.
His studies in Purine nucleoside phosphorylase integrate themes in fields like Guanosine, Reaction coordinate and Nucleophile.
He interconnects Binding site, Hydrogen bond and Hypoxanthine Phosphoribosyltransferase in the investigation of issues within Transition state analog.
A large part of his Enzyme studies is devoted to Purine.
Peter C. Tyler regularly links together related areas like Nucleotide salvage in his Biochemistry studies.
His most cited work include:
- One-Third-the-Sites Transition-State Inhibitors for Purine Nucleoside Phosphorylase† (194 citations)
- Liposomal delivery of antigen to human dendritic cells. (160 citations)
- Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis (159 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Stereochemistry, Purine nucleoside phosphorylase, Biochemistry, Transition state analog and Enzyme.
In his papers, Peter C. Tyler integrates diverse fields, such as Stereochemistry and Transition.
His Purine nucleoside phosphorylase study integrates concerns from other disciplines, such as Transferase, Purine metabolism, Inosine, Leaving group and Purine analogue.
His Biochemistry study frequently draws parallels with other fields, such as Nucleotide salvage.
The various areas that Peter C. Tyler examines in his Transition state analog study include Hydrolase, Polyamine and Binding site.
Enzyme inhibitor is the focus of his Enzyme research.
He most often published in these fields:
- Stereochemistry (55.70%)
- Purine nucleoside phosphorylase (27.85%)
- Biochemistry (27.22%)
What were the highlights of his more recent work (between 2010-2019)?
- Stereochemistry (55.70%)
- Biochemistry (27.22%)
- Enzyme (20.25%)
In recent papers he was focusing on the following fields of study:
Peter C. Tyler mostly deals with Stereochemistry, Biochemistry, Enzyme, Crystal structure and S-adenosylhomocysteine nucleosidase.
Peter C. Tyler combines subjects such as Purine nucleoside phosphorylase, Molecule, Entropy and Stereoselectivity with his study of Stereochemistry.
His Purine nucleoside phosphorylase research incorporates themes from Methylene, Ribitol and Amine gas treating.
His study in Transition state analog and Active site falls under the purview of Enzyme.
Peter C. Tyler has researched Transition state analog in several fields, including Antibiotics and Microbiology.
His study looks at the relationship between Hypoxanthine and topics such as Phosphoribosyltransferase, which overlap with Inosine, Hypoxanthine salvage, Purine, Nucleotide salvage and Inosine monophosphate.
Between 2010 and 2019, his most popular works were:
- Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease (59 citations)
- Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase (41 citations)
- A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pylori (32 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Organic chemistry
- Catalysis
Peter C. Tyler spends much of his time researching Biochemistry, Hypoxanthine, Phosphoribosyltransferase, Stereochemistry and Enzyme.
He undertakes interdisciplinary study in the fields of Biochemistry and Chemical synthesis through his works.
The Hypoxanthine study combines topics in areas such as Purine nucleoside phosphorylase, Purine, Hypoxanthine salvage and Inosine.
His Phosphoribosyltransferase research includes themes of Inosine monophosphate, Xanthine phosphoribosyltransferase, Nucleotide salvage and Purine metabolism.
His research on Stereochemistry focuses in particular on Total synthesis.
His Enzyme research includes elements of HEXA, Sulfation, Glycosylation and Function.
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