D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 50 Citations 9,814 368 World Ranking 8703 National Ranking 37

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • DNA
  • Organic chemistry

David Shugar mainly focuses on Stereochemistry, Biochemistry, Purine nucleoside phosphorylase, Enzyme and Tautomer. Particularly relevant to Nucleoside is his body of work in Stereochemistry. Many of his studies on Biochemistry involve topics that are commonly interrelated, such as Molecular biology.

David Shugar combines subjects such as Guanine, Molecular replacement, Trimer and Inosine with his study of Purine nucleoside phosphorylase. The various areas that David Shugar examines in his Enzyme study include Dimer, Riboside, Oligonucleotide and Binding site. David Shugar has researched Tautomer in several fields, including Fluorescence and Infrared spectroscopy.

His most cited work include:

  • Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus (483 citations)
  • Purine nucleoside phosphorylases: properties, functions, and clinical aspects. (381 citations)
  • Purine nucleoside phosphorylases: properties, functions, and clinical aspects. (381 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Stereochemistry, Biochemistry, Enzyme, Nucleoside and Purine nucleoside phosphorylase. His research integrates issues of Glycosidic bond, Guanine, Substrate and Hydrogen bond in his study of Stereochemistry. His work is dedicated to discovering how Biochemistry, Molecular biology are connected with Deoxyuridine and other disciplines.

His studies deal with areas such as Thymidylate synthase and Hydrolysis as well as Enzyme. His study ties his expertise on Uridine together with the subject of Nucleoside. David Shugar studied Purine nucleoside phosphorylase and Fluorescence that intersect with Tautomer and Photochemistry.

He most often published in these fields:

  • Stereochemistry (60.13%)
  • Biochemistry (38.31%)
  • Enzyme (25.84%)

What were the highlights of his more recent work (between 1996-2016)?

  • Stereochemistry (60.13%)
  • Biochemistry (38.31%)
  • Purine nucleoside phosphorylase (20.71%)

In recent papers he was focusing on the following fields of study:

David Shugar spends much of his time researching Stereochemistry, Biochemistry, Purine nucleoside phosphorylase, Enzyme and Nucleoside. His Stereochemistry research includes themes of Ligand, Guanine, Xanthine, Hydrogen bond and Dissociation constant. In his study, Protein phosphorylation is inextricably linked to Molecular biology, which falls within the broad field of Biochemistry.

His Purine nucleoside phosphorylase study combines topics from a wide range of disciplines, such as Guanosine, Substrate, Inosine and Hypoxanthine. The study incorporates disciplines such as Thymidylate synthase, Fluorescence and Binding site in addition to Enzyme. His studies in Nucleoside integrate themes in fields like Pyrimidine, Phosphate, Purine and Nucleotide salvage.

Between 1996 and 2016, his most popular works were:

  • Purine nucleoside phosphorylases: properties, functions, and clinical aspects. (381 citations)
  • Purine nucleoside phosphorylases: properties, functions, and clinical aspects. (381 citations)
  • Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). (315 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • DNA
  • Organic chemistry

David Shugar mainly investigates Stereochemistry, Purine nucleoside phosphorylase, Biochemistry, Phosphorolysis and Inosine. His Stereochemistry research is mostly focused on the topic Electronic effect. His Purine nucleoside phosphorylase study combines topics in areas such as Hypoxanthine, Trimer, Substrate, Nucleoside and Dissociation constant.

His Biochemistry study frequently draws connections to adjacent fields such as Molecular biology. As part of the same scientific family, David Shugar usually focuses on Inosine, concentrating on Enzyme kinetics and intersecting with Cofactor, Nicotinamide and Non-competitive inhibition. His Enzyme research includes elements of Amino acid and Nucleotide salvage.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus

E. De Clercq;J. Descamps;G. Verhelst;R. T. Walker.
The Journal of Infectious Diseases (1980)

748 Citations

Purine nucleoside phosphorylases: properties, functions, and clinical aspects.

Agnieszka Bzowska;Ewa Kulikowska;David Shugar;David Shugar.
Pharmacology & Therapeutics (2000)

589 Citations

Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

Stefania Sarno;Helen Reddy;Flavio Meggio;Maria Ruzzene.
FEBS Letters (2001)

394 Citations

MATRIX ISOLATION STUDIES OF NUCLEIC ACID CONSTITUENTS. I. INFRARED SPECTRA OF URACIL MONOMERS

M. Szczesniak;M. J. Nowak;H. Rostkowska;Krystyna Szczepaniak.
Journal of the American Chemical Society (1983)

233 Citations

Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2.

Jingbo Pi;Yushi Bai;Jeffrey M. Reece;Jason Williams.
Free Radical Biology and Medicine (2007)

229 Citations

Conformation of the exocyclic 5′-CH2OH in nucleosides and nucleotides in aqueous solution from specific assignments of the H5′, and H5″ signals in the NMR spectra

M. Remin;M. Remin;D. Shugar;D. Shugar.
Biochemical and Biophysical Research Communications (1972)

178 Citations

Ribofuranosyl‐benzimidazole derivatives as inhibitors of casein kinase‐2 and casein kinase‐1

Flavio Meggio;David Shugar;Lorenzo A. Pinna.
FEBS Journal (1990)

169 Citations

Halogenated benzimidazoles and benzotriazoles as selective inhibitors of protein kinases CK I and CK II from Saccharomyces cerevisiae and other sources.

Ryszard Szyszka;Nikodem Grankowski;Krzysztof Felczak;David Shugar.
Biochemical and Biophysical Research Communications (1995)

167 Citations

Mammalian nucleolytic enzymes.

Halina Sierakowska;David Shugar.
Progress in Nucleic Acid Research and Molecular Biology (1977)

162 Citations

Carbon Monoxide Neurotransmission Activated by CK2 Phosphorylation of Heme Oxygenase-2

Darren F. Boehning;Cheil Moon;Sumit Sharma;K. Joseph Hurt.
Neuron (2003)

156 Citations

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