D-Index & Metrics Best Publications
Erik De Clercq

Erik De Clercq

Biology and Biochemistry
Belgium
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 70 Citations 20,190 207 World Ranking 4373 National Ranking 71

Research.com Recognitions

Awards & Achievements

2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Organic chemistry
  • Virus

Erik De Clercq focuses on Virology, Chemical synthesis, Stereochemistry, Immunology and Virus. The Virology study combines topics in areas such as Reverse transcriptase, Reverse-transcriptase inhibitor and Efavirenz. His studies deal with areas such as Bicyclic molecule, Structure–activity relationship, Cytotoxicity and Biological activity as well as Chemical synthesis.

Erik De Clercq has researched Stereochemistry in several fields, including Amantadine, Zinc, Trypanosoma brucei, Cytotoxic T cell and Aryl. As a member of one scientific family, Erik De Clercq mostly works in the field of Immunology, focusing on Drug and, on occasion, Intensive care medicine, Hepatitis C and Hepacivirus. His Virus study combines topics in areas such as RNA-dependent RNA polymerase, Cowpox virus, Variola virus, Microbiology and Molecular biology.

His most cited work include:

  • CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. (851 citations)
  • Antiviral drugs in current clinical use. (738 citations)
  • 1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity. (626 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Stereochemistry, Virology, Virus, Nucleoside and In vitro. His work deals with themes such as Nucleic acid, Ring, Biological activity, Structure–activity relationship and Chemical synthesis, which intersect with Stereochemistry. In his work, Enzyme and Efavirenz is strongly intertwined with Reverse transcriptase, which is a subfield of Virology.

Mutation and DNA is closely connected to Molecular biology in his research, which is encompassed under the umbrella topic of Virus. His studies in Nucleoside integrate themes in fields like Bicyclic molecule, Thymine, Uridine and Pyrimidine. His study in In vitro is interdisciplinary in nature, drawing from both Cell culture and In vivo.

He most often published in these fields:

  • Stereochemistry (38.13%)
  • Virology (32.11%)
  • Virus (18.39%)

What were the highlights of his more recent work (between 2009-2017)?

  • Stereochemistry (38.13%)
  • Virology (32.11%)
  • Pharmacology (9.36%)

In recent papers he was focusing on the following fields of study:

Erik De Clercq mainly focuses on Stereochemistry, Virology, Pharmacology, Virus and Nucleoside. His Stereochemistry research includes themes of Cell culture, IC50, Cytotoxicity, Cytotoxic T cell and Chemical synthesis. His biological study spans a wide range of topics, including Rilpivirine and Reverse transcriptase, Reverse-transcriptase inhibitor.

His Pharmacology research incorporates elements of Integrase, Polymer and Anti hiv activity. His Virus research includes elements of Rubella, Potency, Amantadine and Smallpox. He interconnects Nucleic acid, Pyrimidine, Pyran, Organic chemistry and Viral replication in the investigation of issues within Nucleoside.

Between 2009 and 2017, his most popular works were:

  • A 40-year journey in search of selective antiviral chemotherapy (112 citations)
  • Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents. (98 citations)
  • C-Nucleosides To Be Revisited. (83 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • Virus

His scientific interests lie mostly in Stereochemistry, Virology, Virus, Reverse transcriptase and Nucleoside. His Stereochemistry study integrates concerns from other disciplines, such as Potency, Cell culture, Chemical synthesis and Strain. His Virology study incorporates themes from Rilpivirine and Computational biology.

His studies in Antiviral drug and Cidofovir are all subfields of Virus research. His Reverse transcriptase research incorporates elements of Structural motif, Structure–activity relationship, Drug resistance and Drug discovery. Erik De Clercq has researched Nucleoside in several fields, including Biological activity and Pyrimidine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Antiviral drugs in current clinical use.

Erik De Clercq.
Journal of Clinical Virology (2004)

1154 Citations

CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.

Paola Bezzi;Maria Domercq;Liliana Brambilla;Rossella Galli.
Nature Neuroscience (2001)

1140 Citations

1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity.

Rosa Alvarez;Sonsoles Velázquez;Ana San-Félix;Stefano Aquaro.
Journal of Medicinal Chemistry (1994)

1024 Citations

Acyclic nucleoside phosphonates: a key class of antiviral drugs

Erik De Clercq;Antonín Holý.
Nature Reviews Drug Discovery (2005)

750 Citations

Strategies in the design of antiviral drugs

Erik De Clercq.
Nature Reviews Drug Discovery (2002)

736 Citations

The bicyclam AMD3100 story

Erik De Clercq.
Nature Reviews Drug Discovery (2003)

597 Citations

The design of drugs for HIV and HCV

Erik De Clercq.
Nature Reviews Drug Discovery (2007)

513 Citations

Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection

Erik De Clercq.
Medicinal Research Reviews (2000)

460 Citations

Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections

Erik De Clercq.
Clinical Microbiology Reviews (2003)

422 Citations

Antivirals and antiviral strategies

Erik De Clercq.
Nature Reviews Microbiology (2004)

394 Citations

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