Erik De Clercq

What is he best known for?

The fields of study he is best known for:

• Enzyme
• Organic chemistry
• Virus

Erik De Clercq focuses on Virology, Chemical synthesis, Stereochemistry, Immunology and Virus. The Virology study combines topics in areas such as Reverse transcriptase, Reverse-transcriptase inhibitor and Efavirenz. His studies deal with areas such as Bicyclic molecule, Structure–activity relationship, Cytotoxicity and Biological activity as well as Chemical synthesis.

Erik De Clercq has researched Stereochemistry in several fields, including Amantadine, Zinc, Trypanosoma brucei, Cytotoxic T cell and Aryl. As a member of one scientific family, Erik De Clercq mostly works in the field of Immunology, focusing on Drug and, on occasion, Intensive care medicine, Hepatitis C and Hepacivirus. His Virus study combines topics in areas such as RNA-dependent RNA polymerase, Cowpox virus, Variola virus, Microbiology and Molecular biology.

His most cited work include:

• CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. (851 citations)
• Antiviral drugs in current clinical use. (738 citations)
• 1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity. (626 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Stereochemistry, Virology, Virus, Nucleoside and In vitro. His work deals with themes such as Nucleic acid, Ring, Biological activity, Structure–activity relationship and Chemical synthesis, which intersect with Stereochemistry. In his work, Enzyme and Efavirenz is strongly intertwined with Reverse transcriptase, which is a subfield of Virology.

Mutation and DNA is closely connected to Molecular biology in his research, which is encompassed under the umbrella topic of Virus. His studies in Nucleoside integrate themes in fields like Bicyclic molecule, Thymine, Uridine and Pyrimidine. His study in In vitro is interdisciplinary in nature, drawing from both Cell culture and In vivo.

He most often published in these fields:

• Stereochemistry (38.13%)
• Virology (32.11%)
• Virus (18.39%)

What were the highlights of his more recent work (between 2009-2017)?

• Stereochemistry (38.13%)
• Virology (32.11%)
• Pharmacology (9.36%)

In recent papers he was focusing on the following fields of study:

Erik De Clercq mainly focuses on Stereochemistry, Virology, Pharmacology, Virus and Nucleoside. His Stereochemistry research includes themes of Cell culture, IC50, Cytotoxicity, Cytotoxic T cell and Chemical synthesis. His biological study spans a wide range of topics, including Rilpivirine and Reverse transcriptase, Reverse-transcriptase inhibitor.

His Pharmacology research incorporates elements of Integrase, Polymer and Anti hiv activity. His Virus research includes elements of Rubella, Potency, Amantadine and Smallpox. He interconnects Nucleic acid, Pyrimidine, Pyran, Organic chemistry and Viral replication in the investigation of issues within Nucleoside.

Between 2009 and 2017, his most popular works were:

• A 40-year journey in search of selective antiviral chemotherapy (112 citations)
• Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents. (98 citations)
• C-Nucleosides To Be Revisited. (83 citations)

In his most recent research, the most cited papers focused on:

• Enzyme
• Organic chemistry
• Virus

His scientific interests lie mostly in Stereochemistry, Virology, Virus, Reverse transcriptase and Nucleoside. His Stereochemistry study integrates concerns from other disciplines, such as Potency, Cell culture, Chemical synthesis and Strain. His Virology study incorporates themes from Rilpivirine and Computational biology.

His studies in Antiviral drug and Cidofovir are all subfields of Virus research. His Reverse transcriptase research incorporates elements of Structural motif, Structure–activity relationship, Drug resistance and Drug discovery. Erik De Clercq has researched Nucleoside in several fields, including Biological activity and Pyrimidine.