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D-Index & Metrics

Chemistry

D-Index
55
Citations
11507
World Ranking
12073
National Ranking
1909

Overview

Xinyong Liu is affiliated with Shandong University in China and has a substantial body of research output primarily in the fields of Medicine and Immunology and Microbiology. Their work focuses extensively on infectious diseases, virology, and molecular biology, intersecting with epidemiology and organic chemistry.

Their research topics encompass a range of areas including:

  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Click Chemistry and Applications
  • Hepatitis C virus research
  • Computational Drug Discovery Methods
  • Influenza Virus Research Studies

Liu has published in multiple scientific journals, with frequent appearances in:

  • Journal of Medicinal Chemistry (34 publications)
  • European Journal of Medicinal Chemistry (33 publications)
  • Molecules (9 publications)
  • Bioorganic & Medicinal Chemistry (8 publications)
  • International Journal of Molecular Sciences (7 publications)

Recent significant papers include:

  • "Fsp3: A new parameter for drug-likeness," 2020, Drug Discovery Today
  • "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling," 2020, Signal Transduction and Targeted Therapy
  • "Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities," 2020, Journal of Medicinal Chemistry
  • "Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses," 2021, Chemical Society Reviews
  • "SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules," 2022, Signal Transduction and Targeted Therapy

Liu collaborates frequently with a range of coauthors, notably:

  • Peng Zhan (112 joint papers)
  • Dongwei Kang (89 joint papers)
  • Christophe Pannecouque (68 joint papers)
  • Erik De Clercq (67 joint papers)
  • Shujing Xu (46 joint papers)

In addition to journal publications, Liu has contributed to book publications. One such work is titled "Antiviral Drug Discovery and Development," published in 2021 by Springer Nature, which has been cited in other research contexts.

Best Publications

  • Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

    Peng Zhan;Christophe Pannecouque;Erik De Clercq;Xinyong Liu

  • Fsp3: A new parameter for drug-likeness.

    Wenxiu Wei;Srinivasulu Cherukupalli;Lanlan Jing;Xinyong Liu

  • HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and implications for drug design.

    Peng Zhan;Xuwang Chen;Dongyue Li;Zengjun Fang

  • Conformational restriction: an effective tactic in 'follow-on'-based drug discovery

    Zengjun Fang;Yu'ning Song;Peng Zhan;Qingzhu Zhang

  • 8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential

    Yu'ning Song;Hao Xu;Wenmin Chen;Peng Zhan

  • Recent applications of click chemistry in drug discovery.

    Xiangyi Jiang;Xia Hao;Lanlan Jing;Gaochan Wu

  • Current drug research on PEGylation with small molecular agents

    Wenjun Li;Peng Zhan;Erik De Clercq;Hongxiang Lou

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling.

    Yi Zheng;Meng Wei Zhuang;Lulu Han;Jing Zhang

  • Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities.

    Siyu Xiu;Alexej Dick;Han Ju;Sako Mirzaie

  • Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries.

    Xueshun Wang;Boshi Huang;Xinyong Liu;Peng Zhan

  • The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic

    Vigneshwaran Namasivayam;Murugesan Vanangamudi;Victor G. Kramer;Sonali Kurup

  • Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.

    Dongwei Kang;Zengjun Fang;Zhenyu Li;Boshi Huang

  • Overview of Recent Strategic Advances in Medicinal Chemistry

    Gaochan Wu;Tong Zhao;Dongwei Kang;Jian Zhang

  • Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms

    Dongyue Li;Peng Zhan;Erik De Clercq;Xinyong Liu

  • Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses

    Yue Ma;Estrella Frutos-Beltrán;Dongwei Kang;Christophe Pannecouque

  • 1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents

    Z. Li;P. Zhan;X. Liu

  • Recent advances in DAPYs and related analogues as HIV-1 NNRTIs.

    Xuwang Chen;Peng Zhan;Dongyue Li;Erik De Clercq

  • Design Strategies of Novel NNRTIs to Overcome Drug Resistance

    Peng Zhan;Xinyong Liu;Zhenyu Li;Christophe Pannecouque

  • Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants

    Dongwei Kang;Zengjun Fang;Boshi Huang;Xueyi Lu

  • Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: Optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches

    Boshi Huang;Cuicui Li;Wenmin Chen;Tao Liu

  • Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies

    Peng Zhan;Xinyong Liu;Zhenyu Li;Zengjun Fang

  • Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

    Ye Tian;Zhaoqiang Liu;Jinghan Liu;Boshi Huang

  • Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: Design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives

    Ye Tian;Deping Du;Diwakar Rai;Liu Wang

  • New techniques and strategies in drug discovery

    Jintong Du;Jing Guo;Dongwei Kang;Zhihong Li

Frequent Co-Authors

Peng Zhan
Peng Zhan Shandong University
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research
Jan Balzarini
Jan Balzarini KU Leuven
Luis Menéndez-Arias
Luis Menéndez-Arias Spanish National Research Council
Chin Ho Chen
Chin Ho Chen Duke University
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Lieve Naesens
Lieve Naesens Rega Institute for Medical Research
Jacob Kongsted
Jacob Kongsted University of Southern Denmark
Hong Liu
Hong Liu Shandong University

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