World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
85
Citations
22384
World Ranking
2725
National Ranking
940

Biology and Biochemistry

D-Index
85
Citations
22585
World Ranking
3194
National Ranking
1614

Research.com Recognitions

  • 2013 - Fellow, National Academy of Inventors
  • 2007 - Member of the National Academy of Sciences
  • 1999 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Vern L. Schramm is affiliated with the Albert Einstein College of Medicine in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these domains, they have contributed extensively to subfields including Molecular Biology, Infectious Diseases, Physiology, Epidemiology, and Surgery.

Their scientific work covers a wide range of topics, notably:

  • Biochemical and Molecular Research
  • HIV/AIDS drug development and treatment
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Clostridium difficile and Clostridium perfringens research
  • Helicobacter pylori-related gastroenterology studies
  • Adenosine and Purinergic Signaling

Schramm has published in several key scientific venues where they have multiple contributions, including:

  • Biochemistry
  • Journal of Biological Chemistry
  • Journal of the American Chemical Society
  • ACS Infectious Diseases
  • ACS Chemical Biology

Their recent notable papers include:

  • "Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues" (2021), published in Nature Communications
  • "Transition-State Analogues of Phenylethanolamine N-Methyltransferase" (2020), published in Journal of the American Chemical Society
  • "Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition" (2023), published in Journal of Biological Chemistry
  • "Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes" (2020), published in ACS Infectious Diseases
  • "Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State" (2022), published in ACS Chemical Biology

Frequent collaborators in their research include:

  • Peter C. Tyler
  • Rajesh K. Harijan
  • Ashleigh S. Paparella
  • Yacoba V. T. Minnow
  • Agnidipta Ghosh

Vern L. Schramm has been recognized with several professional distinctions, including:

  • Fellow of the American Association for the Advancement of Science (AAAS), awarded in 1999
  • Member of the National Academy of Sciences, elected in 2007
  • Fellow of the National Academy of Inventors, awarded in 2013

Best Publications

  • The Biochemistry of Sirtuins

    Anthony A. Sauve;Cynthia Wolberger;Vern L. Schramm;Jef D. Boeke

  • Enzymatic Transition States and Transition State Analog Design

    Vern L. Schramm

  • Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions.

    Anthony A. Sauve;Ivana Celic;Jose Avalos;Haiteng Deng

  • One-Third-the-Sites Transition-State Inhibitors for Purine Nucleoside Phosphorylase†

    Robert W. Miles;Peter C. Tyler;Richard H. Furneaux;Carey K. Bagdassarian

  • Enzymatic transition states and dynamic motion in barrier crossing.

    Steven D Schwartz;Vern L Schramm

  • Sir2 Regulation by Nicotinamide Results from Switching between Base Exchange and Deacetylation Chemistry

    Anthony A. Sauve;Vern L. Schramm

  • Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis

    A Fedorov;W Shi;G Kicska;E Fedorov

  • Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction.

    Paul C. Kline;Vern L. Schramm

  • Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.

    Greg A. Kicska;Li Long;Heidi Hörig;Craig Fairchild

  • Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes.

    Unknown

  • Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases.

    Andrzej Lewandowicz;Vern L Schramm

  • The 2.0 Å structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

    Wuxian Shi;Caroline M. Li;Peter C. Tyler;Richard H. Furneaux

  • Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.

    Jemy A. Gutierrez;Tamara Crowder;Agnes Rinaldo-Matthis;Meng Chiao Ho

  • Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.

    Anthony A. Sauve;Robyn D. Moir;Vern L. Schramm;Ian M. Willis

  • Nucleoside hydrolase from Crithidia fasciculata. Metabolic role, purification, specificity, and kinetic mechanism.

    D W Parkin;B A Horenstein;D R Abdulah;B Estupiñán

  • Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli

    Vipender Singh;Gary B. Evans;Dirk H. Lenz;Jennifer M. Mason

  • Enzymatic transition state theory and transition state analogue design.

    Vern L. Schramm

  • Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase.

    Andrzej Lewandowicz;Peter C. Tyler;Gary B. Evans;Richard H. Furneaux

  • Transition States, Analogues, and Drug Development

    Vern L. Schramm

  • Manganese in metabolism and enzyme function

    Vern L. Schramm;Frederick C. Wedler

  • Enzymatic transition states: thermodynamics, dynamics and analogue design

    Vern L. Schramm

  • Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.

    Wuxian Shi;Li Min Ting;Gregory A. Kicska;Andrzej Lewandowicz

Frequent Co-Authors

Peter C. Tyler
Peter C. Tyler Victoria University of Wellington
Gary B. Evans
Gary B. Evans Victoria University of Wellington
Richard H. Furneaux
Richard H. Furneaux Victoria University of Wellington
Steven C. Almo
Steven C. Almo Albert Einstein College of Medicine
Anthony A. Sauve
Anthony A. Sauve Cornell University
Kami Kim
Kami Kim University of South Florida
Robert Callender
Robert Callender Albert Einstein College of Medicine
Helen M. Berman
Helen M. Berman Rutgers, The State University of New Jersey
James C. Sacchettini
James C. Sacchettini Texas A&M University
Ching C. Wang
Ching C. Wang University of California, San Francisco

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