World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
63
Citations
16846
World Ranking
8311
National Ranking
195

Biology and Biochemistry

D-Index
66
Citations
19912
World Ranking
8521
National Ranking
217

Overview

Luke W. Guddat is affiliated with the University of Queensland in Australia and has contributed extensively to research in biochemistry, genetics, and molecular biology, with a focus on molecular biology and infectious diseases. Their work spans multiple subfields including plant science, epidemiology, and materials chemistry.

The scientist's recent publication record includes studies on SARS-CoV-2 and COVID-19, illustrating detailed investigations into viral protein structures and mechanisms. Notable papers authored or co-authored by them are:

  • Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors (2020, Nature)
  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus (2020, Science)
  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase (2020, Cell)
  • Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur (2020, Nature Structural & Molecular Biology)
  • Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis (2020, Cell)

The scientist frequently collaborates with other researchers, including Zihe Rao, Xiuna Yang, Gerhard Schenk, Haitao Yang, and Yan Gao. These frequent co-authors highlight a collaborative network across related fields of study.

Publication venues where the scientist's work has appeared most often include:

  • Nature Communications
  • Cell
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Protein & Cell

Luke W. Guddat's research topics cover a range of areas, primarily biochemical and molecular research, tuberculosis research and epidemiology, enzyme structure and function, antibiotic resistance in bacteria, SARS-CoV-2 and COVID-19 research, weed control and herbicide applications, and HIV/AIDS drug development and treatment.

The body of work reflects contributions to 106 publications in biochemistry, genetics, and molecular biology, with 82 publications in the medicine field. Subfields are dominated by molecular biology and infectious diseases, underscoring a focus on understanding biological mechanisms at molecular and clinical levels.

Best Publications

  • Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

    Zhenming Jin;Zhenming Jin;Xiaoyu Du;Yechun Xu;Yongqiang Deng

  • Structure of the RNA-dependent RNA polymerase from COVID-19 virus.

    Yan Gao;Yan Gao;Liming Yan;Yucen Huang;Fengjiang Liu

  • Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.

    Quan Wang;Jiqin Wu;Haofeng Wang;Haofeng Wang;Yan Gao

  • The catalytic mechanisms of binuclear metallohydrolases.

    Natasa Mitic;Sarah J. Smith;Ademir Neves;Luke W. Guddat

  • Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase

    Jennifer A. McCourt;Siew Siew Pang;Jack King-Scott;Luke W. Guddat

  • Structure and mechanism of inhibition of plant acetohydroxyacid synthase.

    Ronald G. Duggleby;Jennifer A. McCourt;Luke W. Guddat

  • Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.

    Zhenming Jin;Zhenming Jin;Yao Zhao;Yuan Sun;Bing Zhang

  • Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.

    Bing Zhang;Bing Zhang;Jun Li;Jun Li;Xiaolin Yang;Xiaolin Yang;Lijie Wu

  • Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.

    Liming Yan;Ji Ge;Litao Zheng;Ying Zhang

  • Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors.

    Siew Siew Pang;Ronald G Duggleby;Luke W Guddat

  • Structure, function, and regulation of tartrate-resistant acid phosphatase.

    G.W. Oddie;Gerhard Schenk;N.Z. Angel;N. Walsh

  • Molecular Basis of Sulfonylurea Herbicide Inhibition of Acetohydroxyacid Synthase

    Siew Siew Pang;Luke W. Guddat;Ronald G. Duggleby

  • Crystal structure of mammalian purple acid phosphatase

    Luke W Guddat;Alan S McAlpine;David Hume;Susan Hamilton

  • Crystal structures of reduced and oxidized DsbA: investigation of domain motion and thiolate stabilization

    Luke W. Guddat;James C.A. Bardwell;Jennifer L. Martin

  • Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2

    Unknown

  • Identification of mammalian-like purple acid phosphatases in a wide range of plants

    G Schenk;L W Guddat;Y Ge;L E Carrington

  • Engineering highly functional thermostable proteins using ancestral sequence reconstruction

    Yosephin Gumulya;Yosephin Gumulya;Jong-Min Baek;Shun-Jie Wun;Raine E. S. Thomson

  • Phosphate forms an unusual tripodal complex with the Fe–Mn center of sweet potato purple acid phosphatase

    Gerhard Schenk;Lawrence R. Gahan;Lyle E. Carrington;Natas ÿa Mitic

  • An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.

    Hongri Gong;Jun Li;Jun Li;Ao Xu;Ao Xu;Yanting Tang

  • Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase.

    Jennifer A. McCourt;Siew Siew Pang;Luke W. Guddat;Ronald G. Duggleby

  • Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction

    Gerhard Schenk;Gerhard Schenk;Nataša Mitić;Lawrence R. Gahan;David L. Ollis

  • Three-dimensional structure of a human immunoglobulin with a hinge deletion

    Luke W. Guddat;James N. Herron;Allen B. Edmundson

  • Structure of Mpro from COVID-19 virus and discovery of its inhibitors

    Z. Jin;Z. Jin;X. Du;Y. Xu;Y. Deng

  • Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre

    L. W. Guddat;A. S. McAlpine;D. A. Hume;S. E Hamilton

Frequent Co-Authors

Gerhard Schenk
Gerhard Schenk University of Queensland
Zihe Rao
Zihe Rao Tsinghua University
Ronald G. Duggleby
Ronald G. Duggleby University of Queensland
Lieve Naesens
Lieve Naesens Rega Institute for Medical Research
Jennifer L. Martin
Jennifer L. Martin University of Wollongong
Yao Zhao
Yao Zhao Beijing Jiaotong University
Lawrence R. Gahan
Lawrence R. Gahan University of Queensland
David A. Hume
David A. Hume University of Queensland
James A. Fraser
James A. Fraser University of Queensland
Martin F. Lavin
Martin F. Lavin University of Queensland

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