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Molecular Biology

D-Index
58
Citations
9934
World Ranking
2109
National Ranking
1046

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Fred D. Ledley is affiliated with Bentley University in the United States. Their research spans several interdisciplinary fields, particularly focusing on the intersection of economics and medicine.

The primary fields of study for Ledley include Economics, Econometrics and Finance, with 31 publications, and Medicine, with 14 publications. Subfields explored in their work cover Economics and Econometrics, Infectious Diseases, Immunology, Public Health, Environmental and Occupational Health, and General Health Professions.

Key research topics addressed by Ledley are Pharmaceutical Economics and Policy, Health Systems, Economic Evaluations, Quality of Life, Innovation Policy and R&D, Biosimilars and Bioanalytical Methods, SARS-CoV-2 and COVID-19 Research, Biotechnology and Related Fields, and Intellectual Property and Patents.

Some of the recent papers authored or coauthored by Ledley include:

  • Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies, 2020, JAMA
  • Comparison of Research Spending on New Drug Approvals by the National Institutes of Health vs the Pharmaceutical Industry, 2010-2019, 2023, JAMA Health Forum
  • NIH funding for vaccine readiness before the COVID-19 pandemic, 2021, Vaccine
  • Spending on Phased Clinical Development of Approved Drugs by the US National Institutes of Health Compared With Industry, 2023, JAMA Health Forum
  • Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies, 2020, Obstetrical & Gynecological Survey

Frequent collaborators in Ledley's research include Ekaterina Galkina Cleary, Matthew J. Jackson, Gregory Vaughan, Edward Zhou, and Sarah Shonka McCoy.

Ledley has contributed to multiple prominent publication venues such as bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Zenodo (CERN European Organization for Nuclear Research), JAMA Health Forum, and SSRN Electronic Journal.

In recognition of their professional contributions, Ledley was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2013.

Best Publications

  • Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products

    Fred D. Ledley

  • Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation.

    Katherine Parker Ponder;Sanjeev Gupta;Frances Leland;Gretchen Darlington

  • Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase

    Simon C. M. Kwok;Fred D. Ledley;Anthony G. DiLella;Kathryn J. H. Robson

  • Pharmaceutical approach to somatic gene therapy.

    Fred D. Ledley

  • Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors

    Brian R. Mullin;Peter H. Fishman;George Lee;Salvatore M. Aloj

  • Molecular structure and polymorphic map of the human phenylalanine hydroxylase gene.

    Anthony G. DiLella;Simon C. M. Kwok;Fred D. Ledley;Joshua Marvit

  • Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases

    Hernan E. Grenett;Fred D. Ledley;Lori L. Reed;Savio L. C. Woo

  • The mouse c-abl locus: molecular cloning and characterization.

    Jean Yin Jen Wang;Fred Ledley;Stephen Goff;Rosalind Lee

  • Contribution of NIH funding to new drug approvals 2010–2016

    Ekaterina Galkina Cleary;Jennifer M. Beierlein;Navleen Surjit Khanuja;Laura M. McNamee

  • Human gene marker/therapy clinical protocols.

    S. A. Rosenberg;R. M. Blaese;M. K. Brenner;A. B. Deisseroth

  • In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection.

    Michael L. Sikes;Bert W. O'Malley;Milton J. Finegold;Fred D. Ledley

  • Identification of a Point Mutation in the Topoisomerase II Gene from a Human Leukemia Cell Line Containing an Amsacrine-resistant Form of Topoisomerase II

    Michael Hinds;Karl Deisseroth;Karl Deisseroth;Janice Mayes;Elizabeth Altschuler

  • Extensive restriction site polymorphism at the human phenylalanine hydroxylase locus and application in prenatal diagnosis of phenylketonuria.

    A. S. Lidsky;F. D. Ledley;A. G. DiLella;S. C. Kwok

  • Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction.

    Ruud Jansen;Frantisek Kalousek;Wayne A. Fenton;Leon E. Rosenberg

  • Why pharmacogenomics? Why now?

    David Housman;Fred D. Ledley

  • Non-viral gene therapy.

    Fred D Ledley

  • Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains.

    Fred D. Ledley;Anthony G. DiLella;Simon C. M. Kwok;Savio L. C. Woo

  • Somatic gene therapy to cells associated with fluid spaces

    Fred D. Ledley;Bert W. O'malley

  • Gene Transfer and Expression of Human Phenylalanine Hydroxylase

    Fred D. Ledley;Hernan E. Grenett;Anthony G. DiLella;Simon C. M. Kwok

  • Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors (hormone mechanism/cholera toxin/luteinizing hormone/human chorionic gonadotropin/adenylate cyclase)

    Brian R. Mullin;H Peter;George Lee;Salvatore M. Aloj

Frequent Co-Authors

Savio L. C. Woo
Savio L. C. Woo Icahn School of Medicine at Mount Sinai
Milton J. Finegold
Milton J. Finegold Baylor College of Medicine
Leonard D. Kohn
Leonard D. Kohn National Institutes of Health
Gretchen J. Darlington
Gretchen J. Darlington Baylor College of Medicine
Dorothy E. Lewis
Dorothy E. Lewis The University of Texas Health Science Center at Houston
David S. Rosenblatt
David S. Rosenblatt McGill University
David H. Ledbetter
David H. Ledbetter University of Florida
Dinah S. Singer
Dinah S. Singer National Institutes of Health
Seymour Kaufman
Seymour Kaufman National Institutes of Health
Arthur L. Beaudet
Arthur L. Beaudet Baylor College of Medicine

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