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Genetics

D-Index
126
Citations
71344
World Ranking
303
National Ranking
160

Medicine

D-Index
126
Citations
71939
World Ranking
2909
National Ranking
1614

Research.com Recognitions

  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

David H. Ledbetter is affiliated with the University of Florida in the United States and has a significant body of research in biochemistry, genetics, molecular biology, and medicine. Their work primarily spans the fields of genetics and related subfields, including cognitive neuroscience, molecular biology, cancer research, and pathology and forensic medicine.

The scientist's research encompasses a range of topics such as genomics and rare diseases, genomic variations and chromosomal abnormalities, autism spectrum disorder research, genetic associations and epidemiology, genetics and neurodevelopmental disorders, cancer genomics and diagnostics, and genetic factors in colorectal cancer.

Some of the recent publications authored or coauthored by David H. Ledbetter include:

  • Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention, 2020, Science
  • Exome sequencing and characterization of 49,960 individuals in the UK Biobank, 2020, Nature
  • Insufficient Evidence for "Autism-Specific" Genes, 2020, The American Journal of Human Genetics
  • Clinical outcomes of a genomic screening program for actionable genetic conditions, 2020, Genetics in Medicine
  • Molecular Diagnostic Yield of Exome Sequencing in Patients With Cerebral Palsy, 2021, JAMA

Frequent coauthors collaborating with Ledbetter include Christa Lese Martin, Scott M. Myers, Matthew T. Oetjens, Brenda Finucane, and H. Lester Kirchner. These collaborations reflect multidisciplinary and extensive work across genetics and clinical fields.

The leading publication venues for this scientist are Genetics in Medicine, The American Journal of Human Genetics, Obstetrical & Gynecological Survey, JAMA, and American Journal of Psychiatry. This indicates a focus on genetics and medical research that intersects with clinical practice and broader biomedical implications.

David H. Ledbetter was awarded the distinction of Fellow of the American Association for the Advancement of Science (AAAS) in 2014, recognizing contributions within the scientific community.

Best Publications

  • Strong Association of De Novo Copy Number Mutations with Autism

    Jonathan Sebat;B. Lakshmi;Dheeraj Malhotra;Jennifer Troge

  • Consensus Statement : Chromosomal Microarray Is a First-Tier Clinical Diagnostic Test for Individuals with Developmental Disabilities or Congenital Anomalies

    David T. Miller;Margaret P. Adam;Margaret P. Adam;Swaroop Aradhya;Leslie G. Biesecker

  • Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

    Suzanne J. Baker;Eric R. Fearon;Janice M. Nigro;Stanley R. Hamilton

  • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

    S. Hong Lee;Stephan Ripke;Stephan Ripke;Benjamin M. Neale;Benjamin M. Neale;Stephen V. Faraone

  • Multicolor Spectral Karyotyping of Human Chromosomes

    E. Schröck;S. du Manoir;T. Veldman;B. Schoell

  • Mapping autism risk loci using genetic linkage and chromosomal rearrangements

    Peter Szatmari;Andrew D. Paterson;Lonnie Zwaigenbaum;Wendy Roberts

  • Chromosomal microarray versus karyotyping for prenatal diagnosis

    Ronald J. Wapner;Christa Lese Martin;Brynn Levy;Blake C. Ballif

  • Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.

    Stephan J. Sanders;Xin He;A. Jeremy Willsey;A. Gulhan Ercan-Sencicek

  • Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

    Stephan J. Sanders;A. Gulhan Ercan-Sencicek;Vanessa Hus;Rui Luo

  • ClinGen — The Clinical Genome Resource

    Heidi L. Rehm;Jonathan S. Berg;Lisa D. Brooks;Carlos D. Bustamante

  • Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats

    Orly Reiner;Romeo Carrozzo;Ying Shen;Manfred Wehnert

  • Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene

    Maricela Alarcón;Brett S. Abrahams;Jennifer L. Stone;Jacqueline A. Duvall

  • The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data

    Sebastian Köhler;Sandra C. Doelken;Christopher J. Mungall;Sebastian Bauer

  • Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

    Frederick E Dewey;Viktoria Gusarova;Richard L Dunbar;Colm T O'Dushlaine

  • Alu polymerase chain reaction: a method for rapid isolation of human-specific sequences from complex DNA sources.

    D L Nelson;S A Ledbetter;L Corbo;M F Victoria

  • Deletions of Chromosome 15 as a Cause of the Prader–Willi Syndrome

    David H. Ledbetter;Vincent M. Riccardi;Susan D. Airhart;Richard J. Strobel

  • Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

    Richard J.L. Anney;Richard J.L. Anney;Stephan Ripke;Stephan Ripke;Stephan Ripke;Verneri Anttila;Jakob Grove;Jakob Grove

  • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

    Colm O'Dushlaine;Lizzy Rossin;Phil H. Lee;Laramie Duncan;Laramie Duncan

  • Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality

    Shinji Hirotsune;Mark W. Fleck;Michael J. Gambello;Gregory J. Bix

  • Linkage, Association, and Gene-Expression Analyses Identify CNTNAP2 as an Autism-Susceptibility Gene. Commentary

    Dietrich A. Stephan;Maricela Alarcon;Brett S. Abrahams;Jennifer L. Stone

Frequent Co-Authors

Christa Lese Martin
Christa Lese Martin Geisinger Health System
William B. Dobyns
William B. Dobyns University of Minnesota
James S. Sutcliffe
James S. Sutcliffe Vanderbilt University
Christopher A. Walsh
Christopher A. Walsh Howard Hughes Medical Institute
Naomichi Matsumoto
Naomichi Matsumoto Yokohama City University
David J. Carey
David J. Carey Geisinger Health System
Daniel H. Geschwind
Daniel H. Geschwind University of California, Los Angeles
Arthur L. Beaudet
Arthur L. Beaudet Baylor College of Medicine
Apiwat Mutirangura
Apiwat Mutirangura Chulalongkorn University
Soma Das
Soma Das University of Chicago

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