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Nelson Dusetti

Nelson Dusetti

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
9167
World Ranking
15227
National Ranking
598

Overview

Nelson Dusetti is affiliated with Inserm in France and has conducted extensive research primarily in the fields of medicine and biochemistry, genetics, and molecular biology. Their work spans several related subfields including oncology, cancer research, molecular biology, pulmonary and respiratory medicine, and surgery.

The researcher's work focuses on several main topics within cancer biology and treatment. These topics include:

  • Pancreatic and Hepatic Oncology Research
  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Epigenetics and DNA Methylation
  • Renal Cell Carcinoma Treatment
  • Cancer, Hypoxia, and Metabolism
  • Cancer Research and Treatments

Nelson Dusetti has published in a variety of scientific journals with a concentration on the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Pancreatology
  • Cancer Research
  • EBioMedicine
  • Annals of Oncology

Their recent publications illustrate a focus on pancreatic cancer and treatment resistance, cellular heterogeneity, and molecular signatures relevant to chemotherapy sensitivity. Selected papers from recent years include:

  • Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer, 2020, Cell Reports Medicine
  • Basal-like and classical cells coexist in pancreatic cancer revealed by single-cell analysis on biopsy-derived pancreatic cancer organoids from the classical subtype, 2020, The FASEB Journal
  • Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer, 2021, Exploration
  • A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma, 2020, Annals of Oncology
  • Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer, 2020, EBioMedicine

Collaborations have been a notable component of their research activities, with frequent co-authors including:

  • Juan Iovanna
  • Rémy Nicolle
  • Nicolás A. Fraunhoffer
  • Martin Bigonnet
  • Odile Gayet

Best Publications

  • Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.

    Meritxell Gironella;Mylène Seux;Min-Jue Xie;Carla Cano

  • Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

    Fabienne Guillaumond;Julie Leca;Orianne Olivares;Marie Noëlle Lavaut

  • Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis.

    Gustavo V. Mallo;Hocine Rechreche;Jean-Marc Frigerio;Dominique Rocha

  • GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

    Paola Martinelli;Enrique Carrillo-de Santa Pau;Trevor Cox;Bruno Sainz

  • Roles for MicroRNAs, miR-93 and miR-130b, and Tumor Protein 53–Induced Nuclear Protein 1 Tumor Suppressor in Cell Growth Dysregulation by Human T-Cell Lymphotrophic Virus 1

    Man Lung Yeung;Jun-ichirou Yasunaga;Jun-ichirou Yasunaga;Yamina Bennasser;Nelson Dusetti

  • Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

    Gwen Lomberk;Yuna Blum;Rémy Nicolle;Asha Nair

  • Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness

    Julie Leca;Sébastien Martinez;Sophie Lac;Jérémy Nigri

  • TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

    Richard Tomasini;Amina Azizi Samir;Alice Carrier;Daniel Isnardon

  • Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.

    Carla E. Cano;Julien Gommeaux;Sylvia Pietri;Marcel Culcasi

  • Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

    Rémy Nicolle;Yuna Blum;Laetitia Marisa;Celine Loncle

  • Tumor necrosis factor α triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation

    David Malka;Sophie Vasseur;Hans Bödeker;Emilia M. Ortiz

  • TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity.

    Richard Tomasini;Mylène Seux;Jonathan Nowak;Caroline Bontemps

  • Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region.

    Nelson J. Dusetti;Emilia M. Ortiz;Gustavo V. Mallo;Jean-Charles Dagorn

  • TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.

    M Seillier;S Peuget;S Peuget;O Gayet;O Gayet;C Gauthier;C Gauthier

  • The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis

    Emilia M. Ortiz;Nelson J. Dusetti;Sophie Vasseur;David Malka

  • Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation.

    Nelson J. Dusetti;Yongfeng Jiang;Maria I. Vaccaro;Richard Tomasini

  • Molecular and functional characterization of the stress-induced protein (SIP) gene and its two transcripts generated by alternative splicing. SIP induced by stress and promotes cell death.

    Richard Tomasini;Amina Azizi Samir;Maria I. Vaccaro;Marie-Josèphe Pebusque

  • Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer.

    Rawand Masoud;Gabriela Reyes-Castellanos;Sophie Lac;Julie Garcia

  • Basal-like and classical cells coexist in pancreatic cancer revealed by single-cell analysis on biopsy-derived pancreatic cancer organoids from the classical subtype.

    Natalia Juiz;Abdessamad Elkaoutari;Martin Bigonnet;Odile Gayet

  • Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas

    Renato M. Lupinacci;Renato M. Lupinacci;Anastasia Goloudina;Olivier Buhard;Jean-Baptiste Bachet

Frequent Co-Authors

Raul Urrutia
Raul Urrutia Medical College of Wisconsin
Jean-Luc Raoul
Jean-Luc Raoul Institut de Cancérologie de l'Ouest (ICO)
Giuseppe Montalto
Giuseppe Montalto University of Palermo
Sabrina Pricl
Sabrina Pricl University of Trieste
Xin Yuan Guan
Xin Yuan Guan University of Hong Kong
Ling Peng
Ling Peng Aix-Marseille University
Stephanie Ma
Stephanie Ma University of Hong Kong
Francisco X. Real
Francisco X. Real Pompeu Fabra University

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