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Biology and Biochemistry

D-Index
66
Citations
15400
World Ranking
8686
National Ranking
586

Overview

Shin Takasawa is affiliated with Nara Medical University in Japan. Their research spans across medicine and biochemistry, genetics, and molecular biology, with a notable focus on physiology and related subfields. The scientist's work broadly covers areas involving obstructive sleep apnea, neuroscience of respiration and sleep, adipose tissue and metabolism, pancreatic function and diabetes, sleep and wakefulness research, high altitude and hypoxia, as well as calcium signaling and nucleotide metabolism.

Takasawa has contributed significantly to several publication venues, primarily in the International Journal of Molecular Sciences, which houses nine of their works. Other frequent venues include Diabetes, with five publications, the Journal of Cellular and Molecular Medicine with three papers, The FASEB Journal, and Proceedings of the Japan Academy Series B.

Their recent publications demonstrate a focus on the physiological and biochemical effects of intermittent hypoxia and related metabolic processes. Recent papers include:

  • "The Impact of Intermittent Hypoxia on Metabolism and Cognition" (2022, International Journal of Molecular Sciences)
  • "Effects of Intermittent Hypoxia on Cytokine Expression Involved in Insulin Resistance" (2021, International Journal of Molecular Sciences)
  • "CD38-Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology" (2022, International Journal of Molecular Sciences)
  • "Intermittent Hypoxia Upregulates the Renin and Cd38 mRNAs in Renin-Producing Cells via the Downregulation of miR-203" (2021, International Journal of Molecular Sciences)
  • "27-Hydroxycholesterol regulates human SLC22A12 gene expression through estrogen receptor action" (2020, The FASEB Journal)

Takasawa has collaborated extensively with several researchers, frequently working alongside Tomoko Uchiyama, Hiroyo Ota, Akiyo Yamauchi, Mai Makino, and Yoshinori Takeda. These partnerships reflect a sustained effort in interdisciplinary studies related to their fields of interest.

The scientist's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their subfields cover:

  • Physiology
  • Cancer Research
  • Surgery
  • Endocrine and Autonomic Systems
  • Genetics

Main topics of their research work include:

  • Obstructive Sleep Apnea Research
  • Neuroscience of respiration and sleep
  • Adipose Tissue and Metabolism
  • Pancreatic function and diabetes
  • Sleep and Wakefulness Research
  • High Altitude and Hypoxia
  • Calcium signaling and nucleotide metabolism

Best Publications

  • Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.

    Hideto Yonekura;Yasuhiko Yamamoto;Shigeru Sakurai;Ralica G. Petrova

  • CD38 is critical for social behaviour by regulating oxytocin secretion

    Duo Jin;Hong Xiang Liu;Hirokazu Hirai;Takashi Torashima

  • Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice

    Yasuhiko Yamamoto;Ichiro Kato;Toshio Doi;Hideto Yonekura

  • Cyclic ADP-ribose in insulin secretion from pancreatic beta cells

    Shin Takasawa;Koji Nata;Hideto Yonekura;Hiroshi Okamoto

  • A novel gene activated in regenerating islets.

    K Terazono;H Yamamoto;S Takasawa;K Shiga

  • Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.

    S Takasawa;A Tohgo;N Noguchi;T Koguma

  • Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein

    T Watanabe;Y Yonemura;H Yonekura;Y Suzuki

  • RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin.

    Khin Mar Myint;Yasuhiko Yamamoto;Toshio Doi;Ichiro Kato

  • Cyclic ADP-ribose Binds to FK506-binding Protein 12.6 to Release Ca2+ from Islet Microsomes

    Naoya Noguchi;Shin Takasawa;Koji Nata;Akira Tohgo

  • CD38 DISRUPTION IMPAIRS GLUCOSE-INDUCED INCREASES IN CYCLIC ADP-RIBOSE, CA2+I, AND INSULIN SECRETION

    Ichiro Kato;Yasuhiko Yamamoto;Miki Fujimura;Naoya Noguchi

  • Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS

    Yasuhiko Yamamoto;Ai Harashima;Hidehito Saito;Koichi Tsuneyama

  • Activation of Reg gene, a gene for insulin-producing β-cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation

    Takako Akiyama;Shin Takasawa;Koji Nata;Seiichi Kobayashi

  • ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1

    Yuichi Hirata;Naoki Kimura;Koh Sato;Yoshiyuki Ohsugi

  • Identification of a Receptor for Reg (Regenerating Gene) Protein, a Pancreatic β-Cell Regeneration Factor

    Seiichi Kobayashi;Takako Akiyama;Koji Nata;Michiaki Abe

  • Transgenic Mice Overexpressing Type 2 Nitric-oxide Synthase in Pancreatic β Cells Develop Insulin-dependent Diabetes without Insulitis

    Toshinari Takamura;Ichiro Kato;Noriko Kimura;Tetsuya Nakazawa

  • Cyclic ADP-ribose modulates Ca2+ release channels for activation by physiological Ca2+ entry in bullfrog sympathetic neurons

    Shao Ying Hua;Takayuki Tokimasa;Shin Takasawa;Yasuhito Furuya

  • Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells.

    Hiroshi Okamoto;Shin Takasawa

  • Increased Expression of HIP/PAP and Regenerating Gene III in Human Inflammatory Bowel Disease and a Murine Bacterial Reconstitution Model

    Hitoshi Ogawa;Kouhei Fukushima;Hiroo Naito;Yuji Funayama

  • Cyclic ADP-ribose and Inositol 1,4,5-Trisphosphate as Alternate Second Messengers for Intracellular Ca2+ Mobilization in Normal and Diabetic β-Cells

    Shin Takasawa;Takako Akiyama;Koji Nata;Michio Kuroki

  • Regulatory Role of CD38 (ADP-ribosyl Cyclase/Cyclic ADP-ribose Hydrolase) in Insulin Secretion by Glucose in Pancreatic βCells ENHANCED INSULIN SECRETION IN CD38-EXPRESSING TRANSGENIC MICE

    Ichiro Kato;Shin Takasawa;Atsuya Akabane;Osamu Tanaka

Frequent Co-Authors

Hiroshi Okamoto
Hiroshi Okamoto Kanazawa University
Hiroshi Okamoto
Hiroshi Okamoto University of Tokyo
Michiaki Unno
Michiaki Unno Tohoku University
Hiroshi Yamamoto
Hiroshi Yamamoto Komatsu University
Yasuhiko Yamamoto
Yasuhiko Yamamoto Kanazawa University
Haruhiro Higashida
Haruhiro Higashida Kanazawa University
Masayoshi Takeuchi
Masayoshi Takeuchi Kanazawa Medical University
Masahide Asano
Masahide Asano Kyoto University
Tsutomu Chiba
Tsutomu Chiba Kyoto University
Mami Noda
Mami Noda Kyushu University

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