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Chemistry

D-Index
42
Citations
7467
World Ranking
17454
National Ranking
4278

Overview

Birandra K. Sinha is a researcher affiliated with the National Institutes of Health in the United States. Their work focuses extensively on the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a total of 22 and 19 publications respectively in these domains.

Their specialized subfields of study include Molecular Biology, Cancer Research, Pulmonary and Respiratory Medicine, Oncology, and Physiology. These areas reflect a broad engagement with cellular and physiological mechanisms, particularly related to cancer biology and respiratory function.

Birandra K. Sinha's research covers a range of main topics, highlighting expertise in:

  • Ferroptosis and cancer prognosis
  • Cancer, Lipids, and Metabolism
  • Drug Transport and Resistance Mechanisms
  • Cancer therapeutics and mechanisms
  • RNA modifications and cancer
  • Nitric Oxide and Endothelin Effects
  • Genomics, phytochemicals, and oxidative stress

Their publications have appeared frequently in specific scientific journals. Main venues include:

  • International Journal of Molecular Sciences
  • Cancers
  • Preprints.org
  • Environmental Health Perspectives
  • Cells

Frequent collaborators in their research efforts comprise several scientists, notably:

  • Erik J. Tokar
  • Carl D. Bortner
  • Ronald E. Cannon
  • Shalyn M. Brown
  • Nilesh Kumar Sharma

Selected recent papers authored or co-authored by Birandra K. Sinha include:

  • Elucidation of Mechanisms of Topotecan-Induced Cell Death in Human Breast MCF-7 Cancer Cells by Gene Expression Analysis, 2020, Frontiers in Genetics
  • NCX-4040, a Unique Nitric Oxide Donor, Induces Reversal of Drug-Resistance in Both ABCB1- and ABCG2-Expressing Multidrug Human Cancer Cells, 2021, Cancers
  • Ferroptosis-Mediated Cell Death Induced by NCX4040, The Non-Steroidal Nitric Oxide Donor, in Human Colorectal Cancer Cells: Implications in Therapy, 2023, Cells

In addition to their own publications, they have contributed to collaborative works such as:

  • Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 at the Blood-Brain Barrier, 2020, Environmental Health Perspectives
  • Understanding Cancer's Defense against Topoisomerase-Active Drugs: A Comprehensive Review, 2024, Cancers

Best Publications

  • Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

    G Batist;A Tulpule;B K Sinha;A G Katki

  • Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats

    Kenneth H. Cowan;Gerald Batist;Anil Tulpule;Birandra K. Sinha

  • Adriamycin-induced Free Radical Formation in the Perfused Rat Heart: Implications for Cardiotoxicity

    Sankaran Rajagopalan;Pedro M. Politi;Birandra K. Sinha;Charles E. Myers

  • Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action

    Birandra K. Sinha;Aspandiar G. Katki;Gerald Batist;Kenneth H. Cowan

  • Topoisomerase inhibitors. A review of their therapeutic potential in cancer.

    Birandra K. Sinha

  • Free radicals and anticancer drug resistance: oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors.

    Birandra K. Sinha;Edward G. Mimnaugh

  • Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance.

    Birandra K. Sinha;Edward G. Mimnaugh;Sankaran Rajagopalan;Charles E. Myers

  • Hydroxyl radical production and DNA damage induced by anthracycline-iron complex

    Josephia R.F. Muindi;Birandra K. Sinha;Luca Gianni;Charles E. Myers

  • Potentiation of Doxorubicin Cytotoxicity by Buthionine Sulfoximine in Multidrug-resistant Human Breast Tumor Cells

    Lata Dusre;Edward G. Mimnaugh;Charles E. Myers;Birandra K. Sinha

  • Enzymatic activation of hydrazine derivatives. A spin-trapping study.

    B K Sinha

  • Free radicals in anticancer drug pharmacology.

    Birandra K. Sinha

  • Role of one-electron and two-electron reduction products of adriamycin and daunomycin in deoxyribonucleic acid binding

    Birandra K. Sinha;J. Lewis Gregory

  • Adriamycin-stimulated hydroxyl radical formation in human breast tumor cells

    Birandra K. Sinha;Aspandiar G. Katki;Gerald Batist;Kenneth H. Cowan

  • Binding mode of chemically activated semiquinone free radicals from quinone anticancer agents to DNA

    B.K. Sinha;C.F. Chignell

  • Enzymatic Activation and Binding of Adriamycin to Nuclear DNA

    Birandra K. Sinha;Michael A. Trush;Katherine A. Kennedy;Edward G. Mimnaugh

  • Adriamycin-enhanced Membrane Lipid Peroxidation in Isolated Rat Nuclei

    Edward G. Mimnaugh;Katherine A. Kennedy;Michael A. Trush;Birandra K. Sinha

  • Formation of superoxide and hydroxyl radicals from 1-methyl-4-phenylpyridinium ion(MPP+): Reductive activation by NADPH cytochrome P-450 reductase

    Birandra K. Sinha;Yogendra Singh;Gopal Krishna

  • Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation.

    E. Schneider;H. Yamazaki;H. Yamazaki;B. K. Sinha;K. H. Cowan

  • Peroxidase-catalyzed Metabolism of Etoposide (VP-16-213) and Covalent Binding of Reactive Intermediates to Cellular Macromolecules

    Nissim Haim;Josef Nemec;John Roman;Birandra K. Sinha

  • An electron spin resonance study of the reduction of peroxides by anthracycline semiquinones

    B. Kalyanaraman;Roger C. Sealy;B.K. Sinha

  • DNA Strand Breaks Produced by Etoposide (VP-16,213) in Sensitive and Resistant Human Breast Tumor Cells: Implications for the Mechanism of Action

    Birandra K. Sinha;Nissim Haim;Lata Dusre;Donna Kerrigan

  • OVEREXPRESSION OF NOVEL ANIONIC GLUTATHIONE TRANSFERASEIN MULTIDRUG RESISTANT HUMAN BREAST CANCER CELLS

    G Batist;A Tulpule;B K Sinha;A C Katki

Frequent Co-Authors

Charles E. Myers
Charles E. Myers University of Virginia
Colin F. Chignell
Colin F. Chignell National Institutes of Health
Ronald P. Mason
Ronald P. Mason National Institutes of Health
Balaraman Kalyanaraman
Balaraman Kalyanaraman Medical College of Wisconsin
Kenneth H. Cowan
Kenneth H. Cowan University of Nebraska Medical Center
Carl D. Bortner
Carl D. Bortner National Institutes of Health
Prem Seth
Prem Seth University of Chicago
Yves Pommier
Yves Pommier National Institutes of Health
Michael A. Trush
Michael A. Trush Johns Hopkins University
Lalith Perera
Lalith Perera National Institutes of Health

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