World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
10739
World Ranking
10465
National Ranking
4544

Overview

Prem Seth is affiliated with the University of Chicago in the United States, contributing to research primarily within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research spans several subfields including Genetics, Oncology, Biotechnology, Biomedical Engineering, and Molecular Medicine.

Their work focuses on topics such as virus-based gene therapy research, CAR-T cell therapy research, cancer research and treatments, and hydrogels covering synthesis, properties, and applications. Additional topics include nanowire synthesis and applications, electrospun nanofibers in biomedical applications, and polymer surface interaction studies.

Prem Seth has published research in a range of scientific journals with a particular emphasis on venues such as Human Gene Therapy, Advanced Healthcare Materials, Cellular Immunology, Cancer Gene Therapy, and Cancer Research. The notable publication venues include:

  • Human Gene Therapy (4 publications)
  • Advanced Healthcare Materials (2 publications)
  • Cellular Immunology (1 publication)
  • Cancer Gene Therapy (1 publication)
  • Cancer Research (1 publication)

Frequent collaborators in their research include Yuefeng Yang, Jens Friedrichs, Nicole Fertala, Carsten Werner, and Hua Wang.

Recent publications by Prem Seth cover topics including hydrogels with tunable viscoelasticity for directing stem cells and the role of oncolytic viruses in cancer immunotherapy. Selected recent papers include:

  • Interpenetrating Polymer Network Hydrogels with Tunable Viscoelasticity and Proteolytic Cleavability to Direct Stem Cells In Vitro, 2024, Advanced Healthcare Materials
  • Call for Special Issue Papers: Oncolytic Viruses and Cancer Immunotherapy, 2020, Human Gene Therapy
  • Oncolytic adenovirus targeting TGF-β enhances anti-tumor responses of mesothelin-targeted chimeric antigen receptor T cell therapy against breast cancer, 2020, Cellular Immunology
  • LyP-1-Modified Oncolytic Adenoviruses Targeting Transforming Growth Factor β Inhibit Tumor Growth and Metastases and Augment Immune Checkpoint Inhibitor Therapy in Breast Cancer Mouse Models, 2020, Human Gene Therapy
  • Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice, 2020, Cancer Gene Therapy

Best Publications

  • New Paradigm for Lymphocyte Granule-mediated Cytotoxicity: TARGET CELLS BIND AND INTERNALIZE GRANZYME B, BUT AN ENDOSOMOLYTIC AGENT IS NECESSARY FOR CYTOSOLIC DELIVERY AND SUBSEQUENT APOPTOSIS *

    Christopher J. Froelich;Kim A Orth;Jane Turbov;Prem Seth

  • Promoting Apoptosis: A Novel Activity Associated With the Cyclin-Dependent Kinase Inhibitor p27

    Yu Katayose;Min Kim;Amol N. S. Rakkar;Zhuangwu Li

  • p53 regulates the expression of the tumor suppressor gene maspin.

    Zhiqiang Zou;Chunling Gao;Akhilesh K. Nagaich;Theresa Connell

  • p21 Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

    Myriam Gorospe;Corrado Cirielli;Xiantao Wang;Prem Seth

  • Inhibitory Function of p21Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control

    Ferdinando Di Cunto;Gabrielle Topley;Enzo Calautti;Jimmy Hsiao

  • Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.

    Michael J. Pinkoski;Marita Hobman;Jeffrey A. Heibein;Kevin Tomaselli

  • Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis

    Jennifer L.M. Gervais;Prem Seth;Hui Zhang

  • A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells.

    Caroline Craig;Robert Wersto;Min Kim;Ekta Ohri

  • Granule-mediated killing: Pathways for granzyme B-initiated apoptosis

    Robert V. Talanian;Xiao He Yang;Jane Turbov;Prem Seth

  • Multifaceted Regulation of Cell Cycle Progression by Estrogen: Regulation of Cdk Inhibitors and Cdc25A Independent of Cyclin D1-Cdk4 Function

    James S. Foster;Donald C. Henley;Antonin Bukovsky;Prem Seth

  • Granzyme B Mimics Apical Caspases DESCRIPTION OF A UNIFIED PATHWAY FOR TRANS-ACTIVATION OF EXECUTIONER CASPASE-3 AND -7

    Xiaohe Yang;Henning R. Stennicke;Baikun Wang;Douglas R. Green

  • Biology of breast cancer bone metastasis.

    Mojtaba Akhtari;Junaid Mansuri;Kam A. Newman;Theresa M. Guise

  • Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor.

    P Seth;D Fitzgerald;H Ginsberg;M Willingham

  • Adenovirus-mediated augmentation of cell transfection with unmodified plasmid vectors.

    K. Yoshimura;M.A. Rosenfeld;P. Seth;R.G. Crystal

  • Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells.

    Caroline Craig;Min Kim;Ekta Ohri;Robert Wersto

  • The Release of Inflammatory Cytokines from Human Peripheral Blood Mononuclear Cells In Vitro Following Exposure to Adenovirus Variants and Capsid

    James N. Higginbotham;Prem Seth;R. Michael Blaese;W. Jay Ramsey

  • Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53.

    Ren-Wu Chen;Paul A. Saunders;Huafeng Wei;Zhuangwu Li

  • Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells.

    D Katayose;J Gudas;H Nguyen;S Srivastava

  • Adenovirus-Mediated Gene Transfer of the Tumor Suppressor, p53, Induces Apoptosis in Postmitotic Neurons

    R. S. Slack;Daniel Belliveau;M. Rosenberg;J. Atwal

  • pH-dependent lysis of liposomes by adenovirus.

    Robert Blumenthal;Prem Seth;Mark C. Willingham;Ira Pastan

Frequent Co-Authors

Kenneth H. Cowan
Kenneth H. Cowan University of Nebraska Medical Center
Judd W. Moul
Judd W. Moul Duke University
Christopher J. Froelich
Christopher J. Froelich NorthShore University HealthSystem
Mark C. Willingham
Mark C. Willingham Wake Forest University
Robert P. Wersto
Robert P. Wersto National Institutes of Health
Ira Pastan
Ira Pastan Center for Cancer Research
David G. McLeod
David G. McLeod Uniformed Services University of the Health Sciences
Shiv Srivastava
Shiv Srivastava Uniformed Services University of the Health Sciences
Bellur S. Prabhakar
Bellur S. Prabhakar University of Illinois at Chicago
Lee J. Helman
Lee J. Helman Children's Hospital of Los Angeles

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Prem Seth

Trending Scientists