World's Best Scientists 2026 revealed!
R. Chris Bleackley

R. Chris Bleackley

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
13640
World Ranking
10256
National Ranking
354

Overview

R. Chris Bleackley is affiliated with the University of Alberta in Canada. Their academic profile reflects a focus on research activities conducted within a university setting.

As no recent papers, collaborative co-authors, or frequent publication venues are listed, there is limited publicly available information regarding the specific outputs and partnerships of their scientific work.

Similarly, there are no details about book publications, main or subfields of study, or principal topics that have been covered in their research. No awards have been recorded in the available data.

This profile reflects a researcher whose documented publication record and recognized contributions may be minimal or currently not captured in the available datasets.

Best Publications

  • Cytotoxic T lymphocytes: all roads lead to death

    Michele Barry;R. Chris Bleackley

  • T Cell Responses Are Better Correlates of Vaccine Protection in the Elderly

    Janet E. McElhaney;Dongxu Xie;W. David Hager;Mary Beth Barry

  • Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis

    Bruce Motyka;Gregory Korbutt;Michael J Pinkoski;Jeffrey A Heibein

  • Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

    Michele Barry;Jeffrey A. Heibein;Michael J. Pinkoski;Siow-Fong Lee

  • Changes in Endoplasmic Reticulum Luminal Environment Affect Cell Sensitivity to Apoptosis

    Kimitoshi Nakamura;Kimitoshi Nakamura;Ella Bossy-Wetzel;Kimberly Burns;Kimberly Burns;Marc P. Fadel

  • Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax.

    Jeffrey A. Heibein;Ing Swie Goping;Michele Barry;Michael J. Pinkoski

  • The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis.

    Gao Chen;Reena Ray;Don Dubik;Lianfa Shi

  • Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.

    Jerome Thiery;Dennis Keefe;Dennis Keefe;Steeve Boulant;Steeve Boulant;Emmanuel Boucrot;Emmanuel Boucrot

  • Granzyme B: a natural born killer

    Sarah J. Lord;Ray V. Rajotte;Gregory S. Korbutt;R. Chris Bleackley

  • Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

    Joanna Baginska;Elodie Viry;Guy Berchem;Aurélie Poli

  • Granzyme B Is Inhibited by the Cowpox Virus Serpin Cytokine Response Modifier A

    Long T. Quan;Antonio Caputo;R. Chris Bleackley;David J. Pickup

  • Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis.

    Michael J. Pinkoski;Marita Hobman;Jeffrey A. Heibein;Kevin Tomaselli

  • The Unmet Need in the Elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

    Janet E. McElhaney;Xin Zhou;H. Keipp Talbot;Ernst Soethout

  • Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition.

    Ing Swie Goping;Michele Barry;Peter Liston;Tracy Sawchuk

  • Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway.

    Michael J. Pinkoski;Nigel J. Waterhouse;Jeffrey A. Heibein;Beni B. Wolf

  • Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.

    Janet E. McElhaney;Janet E. McElhaney;Catherine Ewen;Xin Zhou;Kevin P. Kane

  • Cytotoxic T Lymphocyte-assisted Suicide CASPASE 3 ACTIVATION IS PRIMARILY THE RESULT OF THE DIRECT ACTION OF GRANZYME B

    Eric A. Atkinson;Michele Barry;Alison J. Darmon;Irene Shostak

  • Cleavage of CPP32 by granzyme B represents a critical role for granzyme B in the induction of target cell DNA fragmentation.

    Alison J. Darmon;Timothy J. Ley;Donald W. Nicholson;R. Chris Bleackley

  • M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes.

    Helen Everett;Michele Barry;Siow Fong Lee;Xuejun Sun

  • Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets.

    W Suarez-Pinzon;O Sorensen;R C Bleackley;J F Elliott

Frequent Co-Authors

Janet E. McElhaney
Janet E. McElhaney Health Sciences North
Ray V. Rajotte
Ray V. Rajotte University of Alberta
David J. Granville
David J. Granville University of British Columbia
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Marek Michalak
Marek Michalak University of Alberta
Grant McFadden
Grant McFadden Arizona State University
Gordon C. Shore
Gordon C. Shore McGill University
Bruce M. McManus
Bruce M. McManus University of British Columbia
Bhagirath Singh
Bhagirath Singh University of Western Ontario
Michal Opas
Michal Opas University of Toronto

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