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Biology and Biochemistry

D-Index
78
Citations
20853
World Ranking
4559
National Ranking
2217

Overview

Kenneth H. Cowan is affiliated with the University of Nebraska Medical Center in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with notable contributions within the subfields of Molecular Biology, Cancer Research, Oncology, Genetics, and Pathology and Forensic Medicine.

The scientist's work focuses on key topics including Cancer Genomics and Diagnostics, Breast Cancer Treatment Studies, BRCA gene mutations in cancer, Genetic factors in colorectal cancer, Epigenetics and DNA Methylation, Cancer Cells and Metastasis, as well as Proteoglycans and glycosaminoglycans research.

Kenneth H. Cowan has contributed to several publications in diverse academic venues. Frequent publication outlets include:

  • Zenodo (CERN European Organization for Nuclear Research)
  • American Journal of Respiratory and Critical Care Medicine
  • Epigenetics
  • The Journal of Pathology
  • JCO Precision Oncology

Notable recent papers include:

  • Association of SOD3 promoter DNA methylation with its down-regulation in breast carcinomas, 2020, Epigenetics
  • Distinct Neoadjuvant Chemotherapy Response and 5-Year Outcome in Patients With Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Tumors That Reclassify as Basal-Type by the 80-Gene Signature, 2022, JCO Precision Oncology
  • Receptor for hyaluronan-mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients, 2023, The Journal of Pathology
  • The mutational landscape of a US Midwestern breast cancer cohort reveals subtype-specific cancer drivers and prognostic markers, 2023, Human Genomics
  • MammaPrint Index as a predictive biomarker for neoadjuvant chemotherapy response and outcome in patients with HR+HER2- breast cancer in NBRST, 2023, Journal of Clinical Oncology

Kenneth H. Cowan collaborates frequently with other researchers. Prominent coauthors include Michelle Desler, Oleg Shats, Chittibabu Guda, Sarah E Tarullo, and Yuyu He, with coauthorship counts ranging from two to six publications per individual.

Best Publications

  • Ten-Year Results of a Comparison of Conservation with Mastectomy in the Treatment of Stage I and II Breast Cancer

    Joan A. Jacobson;David N. Danforth;Kenneth H. Cowan;Teresa D'angelo

  • The pharmacology and clinical use of methotrexate

    Jacques Jolivet;Kenneth H. Cowan;Gregory A. Curt;Neil J. Clendeninn

  • Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

    G Batist;A Tulpule;B K Sinha;A G Katki

  • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.

    Ronit I. Yarden;Sherly Pardo-Reoyo;Magda Sgagias;Kenneth H. Cowan

  • The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells.

    Min Kim;Heth Turnquist;John Jackson;Magda Sgagias

  • Promoting Apoptosis: A Novel Activity Associated With the Cyclin-Dependent Kinase Inhibitor p27

    Yu Katayose;Min Kim;Amol N. S. Rakkar;Zhuangwu Li

  • Expression of Anionic Glutathione-S-transferase and P-Glycoprotein Genes in Human Tissues and Tumors

    Jeffrey A. Moscow;Craig R. Fairchild;Mary Jane Madden;David T. Ransom

  • Constraints on CD4 Recovery Postchemotherapy in Adults: Thymic Insufficiency and Apoptotic Decline of Expanded Peripheral CD4 Cells

    Frances T. Hakim;Rosemarie Cepeda;Song Kaimei;Crystal L. Mackall

  • Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats

    Kenneth H. Cowan;Gerald Batist;Anil Tulpule;Birandra K. Sinha

  • Isolation of Amplified and Overexpressed DNA Sequences from Adriamycin- resistant Human Breast Cancer Cells

    C. R. Fairchild;S. P. Ivy;C. S. Kao-Shan;J. Whang-Peng

  • Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.

    Erasmus Schneider;Julie K. Horton;Julie K. Horton;Chih Hsin Yang;Masayuki Nakagawa

  • Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer.

    J. Zujewski;I.D. Horak;C.J. Bol;R. Woestenborghs

  • A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells

    Katharine H. Dixon;Brendan C. Lanpher;Jason Chiu;Kristin Kelley

  • BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression

    Timothy K. MacLachlan;Kumaravel Somasundaram;Magda Sgagias;Yelena Shifman

  • Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas

    C. R. Fairchild;S. P. Ivy;T. Rushmore;G. Lee

  • Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action

    Birandra K. Sinha;Aspandiar G. Katki;Gerald Batist;Kenneth H. Cowan

  • Hormone-dependent Regulation of BRCA1 in Human Breast Cancer Cells

    Jean M. Gudas;Hoang Nguyen;Tao Li;Kenneth H. Cowan

  • Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells.

    Jeffrey A. Moscow;Maokai Gong;Rui He;Magdalene K. Sgagias

  • A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells.

    Caroline Craig;Robert Wersto;Min Kim;Ekta Ohri

  • Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia.

    Erasmus Schneider;Kenneth H. Cowan;Helaine Bader;Sara Toomey

Frequent Co-Authors

Prem Seth
Prem Seth University of Chicago
Ronald E. Gress
Ronald E. Gress National Institutes of Health
Charles E. Myers
Charles E. Myers University of Virginia
David Venzon
David Venzon National Institutes of Health
Birandra K. Sinha
Birandra K. Sinha National Institutes of Health
Anthony W. Tolcher
Anthony W. Tolcher Texas Oncology
Cynthia E. Dunbar
Cynthia E. Dunbar National Institutes of Health
Seth M. Steinberg
Seth M. Steinberg National Institutes of Health
Arthur W. Nienhuis
Arthur W. Nienhuis St. Jude Children's Research Hospital
Susan F. Leitman
Susan F. Leitman National Institutes of Health

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