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Molecular Biology

D-Index
106
Citations
34755
World Ranking
432
National Ranking
247

Overview

Arthur W. Nienhuis was affiliated with St. Jude Children's Research Hospital in the United States. Throughout their career, they contributed to several areas within medicine and biology, focusing particularly on genetic and molecular aspects of disease.

Their research encompassed multiple fields of study, including:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, their work included subfields such as:

  • Molecular Biology
  • Genetics
  • Epidemiology
  • Surgery
  • Pulmonary and Respiratory Medicine

Topics addressed in their publications covered:

  • CRISPR and Genetic Engineering
  • RNA modifications and cancer
  • Hemoglobinopathies and Related Disorders
  • Infective Endocarditis Diagnosis and Management
  • Cardiac Structural Anomalies and Repair
  • Coronary Artery Anomalies

Among their recent publications was the paper titled "High level of fetal-globin reactivation by designed transcriptional activator-like effector", published in 2020 in the journal Blood Advances.

Frequent collaborators in their research included:

  • Jun Zhan
  • Maria Johnson Irudayam
  • Yukio Nakamura
  • Ryo Kurita
  • Ernest N. Arnett

The journal Blood Advances was among the primary publication venues for their work.

Best Publications

  • Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

    Amit C. Nathwani;Edward G.D. Tuddenham;Savita Rangarajan;Cecilia Rosales

  • Long-term safety and efficacy of factor IX gene therapy in hemophilia B

    Amit C Nathwani;Ulreke M Reiss;Edward G D Tuddenham;Cecilia Rosales;Cecilia Rosales

  • Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major.

    Gary M. Brittenham;Patricia M. Griffith;Arthur W. Nienhuis;Christine E. McLaren

  • Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.

    Brian P. Sorrentino;Stephen J. Brandt;David Bodine;Michael Gottesman

  • An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation

    J T Holt;R L Redner;A W Nienhuis

  • Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.

    R E Donahue;S W Kessler;D Bodine;K McDonagh

  • Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation

    J T Holt;T V Gopal;A D Moulton;A W Nienhuis

  • 5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia.

    Ley Tj;DeSimone J;Anagnou Np;Keller Gh

  • Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy.

    Gary Kurtzman;Norbert Frickhofen;Janice Kimball;Douglas W. Jenkins

  • Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

    S J Brandt;D M Bodine;C E Dunbar;A W Nienhuis

  • Genotoxicity of Retroviral Integration In Hematopoietic Cells

    Arthur W. Nienhuis;Cynthia E. Dunbar;Brian P. Sorrentino

  • Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

    Amit C Nathwani;Amit C Nathwani;Cecilia Rosales;Jenny McIntosh;Ghasem Rastegarlari

  • Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea.

    Griffin P. Rodgers;George J. Dover;Constance Tom Noguchi;Alan N. Schechter

  • Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells

    David M. Bodine;Stefan Karlsson;Arthur W. Nienhuis

  • Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major

    Gary M. Brittenham;Alan R. Cohen;Christine E. McLaren;Marie B. Martin

  • Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

    P A Ney;B P Sorrentino;K T McDonagh;A W Nienhuis

  • 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia

    Timothy J. Ley;Timothy J. Ley;Joseph DeSimone;Joseph DeSimone;Constance Tom Noguchi;Constance Tom Noguchi;Patricia H. Turner;Patricia H. Turner

  • Localization of the human α-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay

    Albert Deisseroth;Arthur Nienhuis;Patricia Turner;Ramon Velez

  • Augmentation by Erythropoietin of the Fetal-Hemoglobin Response to Hydroxyurea in Sickle Cell Disease

    Griffin P. Rodgers;George J. Dover;Nobuhiro Uyesaka;Constance T. Noguchi

  • Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.

    Peiman Hematti;Bum Kee Hong;Cole Ferguson;Rima Adler

Frequent Co-Authors

Derek A. Persons
Derek A. Persons St. Jude Children's Research Hospital
Amit C. Nathwani
Amit C. Nathwani University College London
Brian P. Sorrentino
Brian P. Sorrentino St. Jude Children's Research Hospital
Cynthia E. Dunbar
Cynthia E. Dunbar National Institutes of Health
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Federico Mingozzi
Federico Mingozzi Children's Hospital of Philadelphia
David M. Bodine
David M. Bodine National Institutes of Health
Neal S. Young
Neal S. Young National Institutes of Health
Edward G. D. Tuddenham
Edward G. D. Tuddenham University College London
Mark A. Kay
Mark A. Kay Stanford University

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