World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
16622
World Ranking
12974
National Ranking
5532

Overview

Brian P. Sorrentino was affiliated with St. Jude Children's Research Hospital in the United States. Their research spanned multiple interconnected fields, primarily focusing on biochemistry, genetics, and molecular biology, as well as medicine.

The scientist contributed to several subfields of study including molecular biology, oncology, genetics, and gastroenterology. Their work addressed scientific questions relating to:

  • Virus-based gene therapy research
  • RNA interference and gene delivery
  • CAR-T cell therapy research
  • Drug transport and resistance mechanisms
  • Gastroesophageal reflux and treatments
  • DNA and nucleic acid chemistry

Throughout their career, Sorrentino published in venues such as:

  • Molecular Therapy - Methods & Clinical Development
  • UNC Libraries

Some of their notable recent papers include:

  • 3' UTR-truncated HMGA2 overexpression induces non-malignant in vivo expansion of hematopoietic stem cells in non-human primates (2021) published in Molecular Therapy - Methods & Clinical Development
  • Interaction with the 5D3 Monoclonal Antibody Is Regulated by Intramolecular Rearrangements but Not by Covalent Dimer Formation of the Human ABCG2 Multidrug Transporter (2020) published in UNC Libraries

Sorrentino collaborated with several co-authors during their research career, including Melissa Bonner, Antonio Morales-Hernández, Sheng Zhou, Zhijun Ma, and Jose Condori, each having contributed to different collaborative works.

Best Publications

  • The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

    Sheng Zhou;John D. Schuetz;Kevin D. Bunting;Anne-Marie Colapietro

  • The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

    Yu Liu;John Easton;Ying Shao;Jamie Maciaszek

  • The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme.

    Partha Krishnamurthy;Douglas D. Ross;Douglas D. Ross;Takeo Nakanishi;Kim Bailey-Dell

  • Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo.

    Sheng Zhou;John J. Morris;Yuxiao Barnes;Lubin Lan

  • Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.

    Brian P. Sorrentino;Stephen J. Brandt;David Bodine;Michael Gottesman

  • Genotoxicity of Retroviral Integration In Hematopoietic Cells

    Arthur W. Nienhuis;Cynthia E. Dunbar;Brian P. Sorrentino

  • Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

    P A Ney;B P Sorrentino;K T McDonagh;A W Nienhuis

  • Restoration of Tolerance in Lupus by Targeted Inhibitory Receptor Expression

    Tracy L. McGaha;Brian Sorrentino;Jeffrey V. Ravetch

  • Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency

    Suk See De Ravin;Xiaolin Wu;Susan Moir;Lela Kardava

  • Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells.

    Samantha A. Cicero;Dianna Johnson;Steve Reyntjens;Sharon Frase

  • Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

    Ewelina Mamcarz;Sheng Zhou;Timothy Lockey;Hossam Abdelsamed

  • Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo

    Kevin D. Bunting;Sheng Zhou;Taihe Lu;Brian P. Sorrentino

  • Retroviral-Mediated Transfer of the Green Fluorescent Protein Gene Into Murine Hematopoietic Cells Facilitates Scoring and Selection of Transduced Progenitors In Vitro and Identification of Genetically Modified Cells In Vivo

    Derek A. Persons;James A. Allay;Esther R. Allay;Richard J. Smeyne

  • In vivo selection of retrovirally transduced hematopoietic stem cells

    James A. Allay;Derek A. Persons;Jacques Galipeau;Janice M. Riberdy

  • Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice.

    Kevin D. Bunting;Jacques Galipeau;David Topham;Ely Benaim

  • Clinical strategies for expansion of haematopoietic stem cells

    Brian P Sorrentino

  • Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7

    Donald Orlic;Stacie Anderson;Leslie G. Biesecker;Brian P. Sorrentino

  • Gene therapy: X-SCID transgene leukaemogenicity.

    Adrian J. Thrasher;Adrian J. Thrasher;H. Bobby Gaspar;H. Bobby Gaspar;Christopher Baum;Christopher Baum;Ute Modlich

  • Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.

    Kevin D. Bunting;Heath L. Bradley;Teresa S. Hawley;Richard Moriggl

  • Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer

    Kevin D. Bunting;Mark Y. Sangster;James N. Ihle;Brian P. Sorrentino

Frequent Co-Authors

Arthur W. Nienhuis
Arthur W. Nienhuis St. Jude Children's Research Hospital
John D. Schuetz
John D. Schuetz St. Jude Children's Research Hospital
Derek A. Persons
Derek A. Persons St. Jude Children's Research Hospital
Harry L. Malech
Harry L. Malech National Institutes of Health
Cynthia E. Dunbar
Cynthia E. Dunbar National Institutes of Health
Christopher Baum
Christopher Baum Charité - University Medicine Berlin
Jacques Galipeau
Jacques Galipeau University of Wisconsin–Madison
Clinton F. Stewart
Clinton F. Stewart St. Jude Children's Research Hospital
Hans Peter Kiem
Hans Peter Kiem Fred Hutchinson Cancer Research Center
Kenneth H. Cowan
Kenneth H. Cowan University of Nebraska Medical Center

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