2026 Federico Mingozzi: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	77	1791	1636	883	795	265	31566

Overview

Federico Mingozzi is affiliated with the Children's Hospital of Philadelphia in the United States. Their research primarily focuses on gene therapy, with specific interests in virus-based gene therapy and its applications in treating genetic and hematological disorders.

Their main fields of study include Medicine and Biochemistry, Genetics and Molecular Biology, engaging extensively with subfields such as Genetics, Molecular Biology, Oncology, Hematology, and Physiology. This interdisciplinary approach supports a broad understanding of complex biological systems relevant to gene therapy.

Mingozzi's work covers several key research topics:

Virus-based gene therapy research
CAR-T cell therapy research
CRISPR and Genetic Engineering
Hemophilia Treatment and Research
Lysosomal Storage Disorders Research
RNA Interference and Gene Delivery
Glycogen Storage Diseases and Myoclonus

They have contributed to numerous scientific publications with a focus on gene transfer vectors and immune responses related to gene therapy. Prominent recent papers include:

AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer, 2020, Molecular Therapy
Human Immune Responses to Adeno-Associated Virus (AAV) Vectors, 2020, Frontiers in Immunology
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies, 2020, Nature Medicine
Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A, 2021, New England Journal of Medicine
Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B, 2020, Molecular Therapy

Their frequent co-authors reflect active collaboration in the field, including:

Giuseppe Ronzitti
Fanny Collaud
Séverine Charles
Klaudia Kuranda
Christian Leborgne

Mingozzi regularly publishes in venues that specialize in gene therapy and immunology research, such as:

Molecular Therapy
Molecular Therapy - Methods & Clinical Development
Blood
Human Gene Therapy
Frontiers in Immunology

Best Publications

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh

2593
Citations
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Manno Cs;Pierce Gf;Arruda Vr;Glader B

2495
Citations
Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

Amit C. Nathwani;Edward G.D. Tuddenham;Savita Rangarajan;Cecilia Rosales

2195
Citations
Long-term safety and efficacy of factor IX gene therapy in hemophilia B

Amit C Nathwani;Ulreke M Reiss;Edward G D Tuddenham;Cecilia Rosales;Cecilia Rosales

1397
Citations
Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

Federico Mingozzi;Katherine A. High;Katherine A. High

1238
Citations
Immune responses to AAV vectors: overcoming barriers to successful gene therapy

Federico Mingozzi;Katherine A. High;Katherine A. High;Katherine A. High

1117
Citations
Emerging Issues in AAV-Mediated In Vivo Gene Therapy

Pasqualina Colella;Giuseppe Ronzitti;Federico Mingozzi;Federico Mingozzi

883
Citations
CD8(+) T-cell responses to adeno-associated virus capsid in humans.

Federico Mingozzi;Marcela V Maus;Marcela V Maus;Daniel J Hui;Denise E Sabatino

851
Citations
Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration.

Francesca Simonelli;Albert M Maguire;Albert M Maguire;Francesco Testa;Eric A Pierce

699
Citations
AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer

Helena Costa Verdera;Klaudia Kuranda;Federico Mingozzi

628
Citations
Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer

Federico Mingozzi;Yi-Lin Liu;Eric Dobrzynski;Antje Kaufhold

570
Citations
AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

Jean Bennett;Jean Bennett;Manzar Ashtari;Jennifer Wellman;Kathleen A. Marshall

480
Citations
Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy.

Haiyan Jiang;Linda B. Couto;Susannah Patarroyo-White;Tongyao Liu

457
Citations
Immune responses to AAV in clinical trials.

Federico Mingozzi;Katherine A High

451
Citations
Long-term safety and efficacy following systemic administration of a self-complementary AAV vector encoding human FIX pseudotyped with serotype 5 and 8 capsid proteins.

Amit C Nathwani;Amit C Nathwani;Cecilia Rosales;Jenny McIntosh;Ghasem Rastegarlari

402
Citations
AAV-1–mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

Federico Mingozzi;Janneke J. Meulenberg;Daniel J. Hui;Etiena Basner-Tschakarjan

385
Citations
Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

Federico Mingozzi;Xavier M. Anguela;Xavier M. Anguela;Giulia Pavani;Yifeng Chen;Yifeng Chen

378
Citations
High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

E Ayuso;F Mingozzi;J Montane;X Leon

337
Citations
Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer

Jeannette Bennicelli;John Fraser Wright;John Fraser Wright;Andras Komaromy;Jonathan B Jacobs

329
Citations
Human Immune Responses to Adeno-Associated Virus (AAV) Vectors.

Giuseppe Ronzitti;David-Alexandre Gross;Federico Mingozzi

316
Citations
Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant.

Jenny McIntosh;Jenny McIntosh;Peter J. Lenting;Cecilia Rosales;Cecilia Rosales;Doyoung Lee

302
Citations
Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver

Federico Mingozzi;Nicole C. Hasbrouck;Etiena Basner-Tschakarjan;Shyrie A. Edmonson;Shyrie A. Edmonson

281
Citations
Assessing the potential for AAV vector genotoxicity in a murine model

Hojun Li;Nirav Malani;Shari R. Hamilton;Alexander Schlachterman

275
Citations

Frequent Co-Authors

Katherine A. High Children's Hospital of Philadelphia

J. Fraser Wright Stanford University

Valder R. Arruda University of Pennsylvania

Roland W. Herzog Indiana University

Amit C. Nathwani University College London

Anne S. De Groot University of Georgia

Arthur W. Nienhuis St. Jude Children's Research Hospital

Mark A. Kay Stanford University

Marcela V. Maus Harvard University

Jean Bennett University of Pennsylvania

External Links

Personal website of Federico Mingozzi

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