World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
43755
World Ranking
1098
National Ranking
660

Medicine

D-Index
107
Citations
43745
World Ranking
6234
National Ranking
3325

Research.com Recognitions

  • 2017 - Fellow, National Academy of Inventors

Overview

Guangping Gao is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a significant focus also in Medicine.

The scientist's work heavily involves molecular biology and genetics, investigating advanced techniques in gene therapy and genome editing. Subfields of study highlight expertise in molecular biology, genetics, epidemiology, infectious diseases, and immunology.

Gao's research topics reflect a concentration on virus-based gene therapy, genetic engineering using CRISPR, RNA interference and gene delivery, viral infectious diseases, CAR-T cell therapy, viral gastroenteritis, and herpesvirus infections and treatments. These topics underline the breadth of their work across genetic and infectious disease research domains.

The list of frequent co-authors includes Jun Xie, Dan Wang, Phillip W.L. Tai, Terence R. Flotte, and Erik J. Sontheimer, indicating strong collaborative partnerships within their research network.

Guangping Gao has published extensively in numerous scientific venues. The most frequent publication outlets are:

  • Human Gene Therapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Therapy
  • Molecular Therapy - Methods & Clinical Development
  • Cold Spring Harbor Protocols

Selected recent papers authored with Gao's involvement include:

  • "Viral vector platforms within the gene therapy landscape," 2021, Signal Transduction and Targeted Therapy
  • "CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors," 2020, Cell
  • "Adeno-associated virus as a delivery vector for gene therapy of human diseases," 2024, Signal Transduction and Targeted Therapy
  • "Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases," 2022, Nature Biotechnology
  • "Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice," 2021, Nature Communications

Gao's research contributions have received recognition including the status of Fellow from the National Academy of Inventors awarded in 2017.

Best Publications

  • Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

    Guang-Ping Gao;Mauricio R. Alvira;Lili Wang;Roberto Calcedo

  • Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

    Steven E Raper;Narendra Chirmule;Frank S Lee;Nelson A Wivel

  • Adeno-associated virus vector as a platform for gene therapy delivery

    Dan Wang;Phillip W. L. Tai;Guangping Gao

  • Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

    Guangping Gao;Luk H. Vandenberghe;Mauricio R. Alvira;You Lu

  • Worldwide Epidemiology of Neutralizing Antibodies to Adeno-Associated Viruses

    Roberto Calcedo;Luk H. Vandenberghe;Guangping Gao;Jianping Lin

  • Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

    Hao Yin;Chun-Qing Song;Joseph R. Dorkin;Lihua Julie Zhu

  • Viral vector platforms within the gene therapy landscape

    Jote T. Bulcha;Yi Wang;Hong Ma;Phillip W. L. Tai

  • Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis.

    K. J. Fisher;Guang-Ping Gao;M. D. Weitzman;R. Dematteo

  • Gene therapy vectors based on adeno-associated virus type 1

    Weidong Xiao;Narendra Chirmule;Scott C. Berta;Beth McCullough

  • New recombinant serotypes of AAV vectors.

    Guangping Gao;Luk H. Vandenberghe;James M. Wilson

  • Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.

    G P Gao;Y Yang;J M Wilson

  • Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages.

    Yi Zhang;Narendra Chirmule;Guang Ping Gao;Ruth Qian

  • A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency.

    Steven E. Raper;Marc Yudkoff;Narendra Chirmule;Guang-Ping Gao

  • Adeno-associated viruses undergo substantial evolution in primates during natural infections.

    Guangping Gao;Mauricio R. Alvira;Suryanarayan Somanathan;You Lu

  • Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.

    Michael A. Schnell;Yi Zhang;John Tazelaar;Guang-ping Gao

  • Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column.

    Alberto Auricchio;Markus Hildinger;Erin O'Connor;Guang-Ping Gao

  • Sequestration of Adenoviral Vector by Kupffer Cells Leads to a Nonlinear Dose Response of Transduction in Liver

    Nianjun Tao;Guang-Ping Gao;Michael Parr;Julie Johnston

  • Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer

    Xuehai Ye;Victor M. Rivera;Philip Zoltick;Franklin Cerasoli

  • CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors.

    Dan Wang;Feng Zhang;Guangping Gao

  • Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

    Dan Wang;Haiwei Mou;Shaoyong Li;Yingxiang Li

Frequent Co-Authors

James M. Wilson
James M. Wilson University of Pennsylvania
Luk H. Vandenberghe
Luk H. Vandenberghe Massachusetts Eye and Ear Infirmary
Miguel Sena-Esteves
Miguel Sena-Esteves University of Massachusetts Chan Medical School
Roberto Calcedo
Roberto Calcedo Affinia Therapeutics
Terence R. Flotte
Terence R. Flotte University of Massachusetts Chan Medical School
Peter Bell
Peter Bell University of Pennsylvania
Narendra Chirmule
Narendra Chirmule Amgen (United States)
Christian Mueller
Christian Mueller University of Massachusetts Chan Medical School
Ronald C. Desrosiers
Ronald C. Desrosiers University of Miami
Yuquan Wei
Yuquan Wei Sichuan University

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