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Hildegund C. J. Ertl

Hildegund C. J. Ertl

D-Index & Metrics

Immunology

D-Index
79
Citations
23717
World Ranking
1679
National Ranking
827

Overview

Hildegund C. J. Ertl is affiliated with The Wistar Institute in the United States. Their research focuses on the intersection of medicine, immunology, microbiology, and molecular biology, with a substantial emphasis on virus-based gene therapy, infectious diseases, and immunotherapy.

The researcher has contributed extensively to several fields of study, including:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Subfields of particular relevance to their work include:

  • Genetics
  • Infectious Diseases
  • Epidemiology
  • Immunology
  • Oncology

Their main research topics cover key areas such as:

  • Virus-based gene therapy research
  • SARS-CoV-2 and COVID-19 Research
  • CAR-T cell therapy research
  • Rabies epidemiology and control
  • Hepatitis B Virus Studies
  • Immunotherapy and Immune Responses
  • Virology and Viral Diseases

Frequent publication venues for the scientist's work include:

  • Journal of Hepatology
  • Human Gene Therapy
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Drugs

The scientist has collaborated regularly with several co-authors, notably:

  • Mohadeseh Hasanpourghadi
  • Zhiquan Xiang
  • Mikhail Novikov
  • Dakota Newman
  • Wynetta Giles-Davis

Among their recent papers are:

  • Immunogenicity and toxicity of AAV gene therapy, 2022, Frontiers in Immunology
  • T Cell-Mediated Immune Responses to AAV and AAV Vectors, 2021, Frontiers in Immunology
  • Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways, 2021, Cell Reports Medicine
  • Immunological biomarker discovery in cure regimens for chronic hepatitis B virus infection, 2022, Journal of Hepatology
  • Towards rabies elimination in the Asia-Pacific region: From theory to practice, 2020, Biologicals

Best Publications

  • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

    Manno Cs;Pierce Gf;Arruda Vr;Glader B

  • MHC class I-cestricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses

    Yiping Yang;Yiping Yang;Hildegund C.J. Ertl;James M. Wilson

  • CD8(+) T-cell responses to adeno-associated virus capsid in humans.

    Federico Mingozzi;Marcela V Maus;Marcela V Maus;Daniel J Hui;Denise E Sabatino

  • Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

    Zhiquan Xiang;Hildegund C.J. Ertl

  • Enhancing CD8 + T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy.

    Ying Zhang;Ying Zhang;Raj Kurupati;Ling Liu;Xiang Yang Zhou

  • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo.

    Y. Yang;K. U. Jooss;Q. Su;H. C. J. Ertl

  • Vaccination with a plasmid vector carrying the rabies virus glycoprotein gene induces protective immunity against rabies virus.

    Zhi Quan Xiang;Steven Spitalnik;Minh Tran;William H. Wunner

  • Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo

    Yiping Yang;Zhiquan Xiang;Hildegund C. J. Ertl;James M. Wilson

  • New Insights on Adenovirus as Vaccine Vectors

    Marcio O Lasaro;Hildegund C J Ertl

  • A REPLICATION-DEFECTIVE HUMAN ADENOVIRUS RECOMBINANT SERVES AS A HIGHLY EFFICACIOUS VACCINE CARRIER

    Zhi Quan Xiang;Yiping Yang;Yiping Yang;James M. Wilson;James M. Wilson;Hildegund C.J. Ertl

  • Replication-Defective Vector Based on a Chimpanzee Adenovirus

    Steven F. Farina;Guang-ping Gao;Z. Q. Xiang;John J. Rux

  • Effect of Preexisting Immunity to Adenovirus Human Serotype 5 Antigens on the Immune Responses of Nonhuman Primates to Vaccine Regimens Based on Human- or Chimpanzee-Derived Adenovirus Vectors

    Kimberly McCoy;Nia Tatsis;Birgit Korioth-Schmitz;Marcio O. Lasaro

  • A simian replication-defective adenoviral recombinant vaccine to HIV-1 gag.

    Julie C. Fitzgerald;Guang-Ping Gao;Arturo Reyes-Sandoval;Arturo Reyes-Sandoval;George N. Pavlakis

  • Random migration precedes stable target cell interactions of tumor-infiltrating T cells

    Paulus Mrass;Hajime Takano;Lai Guan Ng;Sachin Daxini

  • The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver

    Ashley T. Martino;Masataka Suzuki;David M. Markusic;Irene Zolotukhin

  • Immune Responses to Nucleic Acid Vaccines to Rabies Virus

    Zhi Quan Xiang;Steve L. Spitalnik;Jun Cheng;Jan Erikson

  • Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines

    Nia Tatsis;Julie C. Fitzgerald;Julie C. Fitzgerald;Arturo Reyes-Sandoval;Arturo Reyes-Sandoval;Kimberly C. Harris-McCoy

  • Induction of protective immunity against rabies by immunization with rabies virus ribonucleoprotein

    Bernhard Dietzschold;Honghai Wang;Charles E. Rupprecht;Esteban Celis

  • Novel, Chimpanzee Serotype 68-Based Adenoviral Vaccine Carrier for Induction of Antibodies to a Transgene Product

    Zhiquan Xiang;Guangping Gao;Arturo Reyes-Sandoval;Christopher J. Cohen

  • Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus.

    Ulrich H. Koszinowski;H. Ertl

Frequent Co-Authors

Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Laszlo Otvos
Laszlo Otvos Semmelweis University
James M. Wilson
James M. Wilson University of Pennsylvania
Kenneth E. Schmader
Kenneth E. Schmader Duke University
Ralf Hoffmann
Ralf Hoffmann Leipzig University
Michael R. Betts
Michael R. Betts University of Pennsylvania
Federico Mingozzi
Federico Mingozzi Children's Hospital of Philadelphia
Yiping Yang
Yiping Yang The Ohio State University
E. John Wherry
E. John Wherry University of Pennsylvania

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