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Takahiko Shimizu

Takahiko Shimizu

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
10412
World Ranking
13966
National Ranking
984

Overview

Takahiko Shimizu is affiliated with Chiba University in Japan, with a research focus rooted primarily in Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans various subfields including Molecular Biology, Physiology, Pharmacology, Public Health, Environmental and Occupational Health, and Biochemistry.

The scientist's recent research contributions feature investigations into mitochondrial function and oxidative stress, reflecting an emphasis on cellular bioenergetics and disease pathology. Notable recent papers include:

  • SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy (2020, Redox Biology)
  • SOD2 in skeletal muscle: New insights from an inducible deletion model (2021, Redox Biology)
  • Short-term resveratrol treatment restored the quality of oocytes in aging mice (2022, Aging)
  • Neuron-specific mitochondrial oxidative stress results in epilepsy, glucose dysregulation and a striking astrocyte response (2021, Neurobiology of Disease)
  • SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential (2024, Redox Biology)

Their research topics cover a range of areas including:

  • Alzheimer's disease research and treatments
  • Mitochondrial Function and Pathology
  • Cholinesterase and Neurodegenerative Diseases
  • Adipose Tissue and Metabolism
  • Neuroscience and Neuropharmacology Research
  • Advanced biosensing and bioanalysis techniques
  • ATP Synthase and ATPases Research

Frequent publication venues for Takahiko Shimizu include:

  • Redox Biology
  • International Journal of Molecular Sciences
  • European Journal of Pharmacology
  • Antioxidants
  • Geriatrics and gerontology international / Geriatrics & gerontology international

Collaboration has been a consistent aspect of their work, with frequent coauthors including:

  • Shuichi Shibuya
  • Naotaka Izuo
  • Kazuhiro Irie
  • Kazuma Murakami
  • Kenji Watanabe

Throughout their career, Takahiko Shimizu has advanced the understanding of oxidative stress mechanisms and mitochondrial dysfunction as they relate to degenerative diseases and pharmacological interventions.

Best Publications

  • Inhibition of autophagy in the heart induces age-related cardiomyopathy.

    Manabu Taneike;Osamu Yamaguchi;Atsuko Nakai;Shungo Hikoso

  • Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration.

    Yutaka Imamura;Setsuko Noda;Kouhei Hashizume;Kei Shinoda

  • Neurotoxicity and Physicochemical Properties of Aβ Mutant Peptides from Cerebral Amyloid Angiopathy: IMPLICATION FOR THE PATHOGENESIS OF CEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE

    Kazuma Murakami;Kazuhiro Irie;Akira Morimoto;Hajime Ohigashi

  • SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease.

    Kazuma Murakami;Nakaba Murata;Yoshihiro Noda;Shoichi Tahara

  • Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans.

    Juewon Kim;Mayumi Takahashi;Takahiko Shimizu;Takuji Shirasawa

  • Oxidative stress causes heart failure with impaired mitochondrial respiration.

    Hidetoshi Nojiri;Takahiko Shimizu;Masabumi Funakoshi;Osamu Yamaguchi

  • Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells.

    Yasutaka Ikeda;Shinji Tsuji;Akira Satoh;Masaharu Ishikura

  • Analysis of the Secondary Structure of β-Amyloid (Aβ42) Fibrils by Systematic Proline Replacement

    Akira Morimoto;Kazuhiro Irie;Kazuma Murakami;Yuichi Masuda

  • Formation and Stabilization Model of the 42-mer Aβ Radical: Implications for the Long-Lasting Oxidative Stress in Alzheimer's Disease

    Kazuma Murakami;Kazuhiro Irie;Hajime Ohigashi;Hideyuki Hara

  • Biological Significance of Isoaspartate and Its Repair System

    Takahiko Shimizu;Yasuji Matsuoka;Takuji Shirasawa

  • Cytoplasmic superoxide causes bone fragility owing to low‐turnover osteoporosis and impaired collagen cross‐linking

    Hidetoshi Nojiri;Yoshitomo Saita;Daichi Morikawa;Keiji Kobayashi

  • Synthesis, aggregation, neurotoxicity, and secondary structure of various Aβ1–42 mutants of familial Alzheimer's disease at positions 21–23

    Kazuma Murakami;Kazuhiro Irie;Akira Morimoto;Hajime Ohigashi

  • CuZn-SOD Deficiency Causes ApoB Degradation and Induces Hepatic Lipid Accumulation by Impaired Lipoprotein Secretion in Mice

    Satoshi Uchiyama;Takahiko Shimizu;Takuji Shirasawa

  • Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.

    Masato Koike;Hidetoshi Nojiri;Yusuke Ozawa;Kenji Watanabe

  • Retinal Dysfunction and Progressive Retinal Cell Death in SOD1-Deficient Mice

    Kouhei Hashizume;Manabu Hirasawa;Yutaka Imamura;Setsuko Noda

  • Identification of Physiological and Toxic Conformations in Aβ42 Aggregates

    Yuichi Masuda;Satoko Uemura;Ryutaro Ohashi;Azusa Nakanishi

  • Structure of β-amyloid fibrils and its relevance to their neurotoxicity: Implications for the pathogenesis of Alzheimer’s disease

    Kazuhiro Irie;Kazuma Murakami;Yuichi Masuda;Akira Morimoto

  • Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease.

    Takahiko Shimizu;Hiroyuki Fukuda;Shigeo Murayama;Naoki Izumiyama

  • Copper/Zinc Superoxide Dismutase Insufficiency Impairs Progesterone Secretion and Fertility in Female Mice

    Yoshihiro Noda;Kuniaki Ota;Takuji Shirasawa;Takahiko Shimizu

  • Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy

    Hirotomo Kuwahara;Tetsuro Horie;Shin Ishikawa;Chizuru Tsuda

Frequent Co-Authors

Takuji Shirasawa
Takuji Shirasawa Shirasawa Anti-Aging Medical Institute
Kazuo Tsubota
Kazuo Tsubota Keio University
Murat Dogru
Murat Dogru Keio University
Hajime Ohigashi
Hajime Ohigashi Kyoto University
Arlan Richardson
Arlan Richardson University of Oklahoma Health Sciences Center
Toshifumi Takao
Toshifumi Takao Osaka University
Holly Van Remmen
Holly Van Remmen Oklahoma Medical Research Foundation
Jun Shimazaki
Jun Shimazaki Tokyo Dental College
Masahiro Maeda
Masahiro Maeda Osaka University
Florian L. Muller
Florian L. Muller The University of Texas MD Anderson Cancer Center

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