World's Best Scientists 2026 revealed!
Siegfried Hekimi

Siegfried Hekimi

D-Index & Metrics

Genetics

D-Index
64
Citations
18482
World Ranking
2767
National Ranking
96

Research.com Recognitions

  • 2010 - Fellow of the Royal Society of Canada Academy of Science

Overview

Siegfried Hekimi is affiliated with McGill University in Canada and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their body of work comprises 45 publications primarily focused on these scientific areas. Within these main fields, their research spans molecular biology, aging, electrical and electronic engineering, biochemistry, and pediatrics, perinatology, and child health.

Their research topics cover a range of subjects, including studies on coenzyme Q10 and its effects, mitochondrial function and pathology, genetics, aging, and longevity in model organisms, advanced battery technologies, biochemical acid research, genomics, phytochemicals and oxidative stress, as well as epigenetics and DNA methylation.

Their publications have appeared frequently in notable venues. These include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PubMed
  • Cell Death and Disease

Some of the recent papers featuring contributions from Hekimi include:

  • "SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans," 2020, Cell Death and Disease
  • "Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis," 2021, Science
  • "The efficacy of coenzyme Q10 treatment in alleviating the symptoms of primary coenzyme Q10 deficiency: A systematic review," 2022, Journal of Cellular and Molecular Medicine
  • "Understanding coenzyme Q," 2024, Physiological Reviews
  • "Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans," 2022, Genetics

The scientist has collaborated frequently with several coauthors, indicating sustained research partnerships. Among these frequent collaborators are Ying Wang, Noah Lilienfeldt, Robyn Branicky, Marlies P. Rossmann, and Brian J. Abraham.

Hekimi has been recognized as a Fellow of the Royal Society of Canada since 2010 under the Academy of Science category.

Best Publications

  • Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling.

    Ying Wang;Robyn Branicky;Alycia Noë;Siegfried Hekimi

  • The genetics of caloric restriction in Caenorhabditis elegans

    Bernard Lakowski;Siegfried Hekimi

  • A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

    Wen Yang;Siegfried Hekimi

  • Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.

    Jinliu Feng;Frédéric Bussière;Siegfried Hekimi

  • Taking a "good" look at free radicals in the aging process.

    Siegfried Hekimi;Jérôme Lapointe;Yang Wen

  • Determination of life-span in Caenorhabditis elegans by four clock genes.

    Bernard Lakowski;Siegfried Hekimi

  • Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

    Jeremy M. Van Raamsdonk;Siegfried Hekimi

  • Genetics and the Specificity of the Aging Process

    Siegfried Hekimi;Leonard Guarente

  • Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

    A Wong;P Boutis;S Hekimi

  • Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging

    Assaf Ben‐Meir;Eliezer Burstein;Aluet Borrego‐Alvarez;Jasmine Chong

  • Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.

    Jonathan J. Ewbank;Thomas M. Barnes;Bernard Lakowski;Marc Lussier

  • The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

    Callista Yee;Wen Yang;Siegfried Hekimi

  • Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

    Xingxing Liu;Ning Jiang;Bryan Hughes;Eve Bigras

  • Superoxide dismutase is dispensable for normal animal lifespan

    Jeremy Michael Van Raamsdonk;Siegfried Hekimi

  • CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.

    S. Felkai;J.J. Ewbank;J. Lemieux;J.‐C Labbé

  • When a theory of aging ages badly

    Jérôme Lapointe;Siegfried Hekimi

  • Meiotic recombination, noncoding DNA and genomic organization in Caenorhabditis elegans.

    T M Barnes;Y Kohara;A Coulson;S Hekimi

  • Early Mitochondrial Dysfunction in Long-lived Mclk1+/- Mice

    Jérôme Lapointe;Siegfried Hekimi

  • Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans.

    Wen Yang;Siegfried Hekimi

  • Innexins: a family of invertebrate gap-junction proteins.

    Pauline Phelan;Jonathan P. Bacon;Jane A. Davies;Lucy A. Stebbings

Frequent Co-Authors

B. O. Hughes
B. O. Hughes Roslin Institute
Eric A. Shoubridge
Eric A. Shoubridge Montreal Neurological Institute and Hospital
Wen Yang
Wen Yang Beijing Institute of Technology
Jonathan J. Ewbank
Jonathan J. Ewbank Aix-Marseille University
Michael O'Shea
Michael O'Shea University of Sussex
Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
Kiyoshi Kita
Kiyoshi Kita Nagasaki University
Andrea Jurisicova
Andrea Jurisicova University of Toronto
Leonard I. Zon
Leonard I. Zon Harvard University
Danielle Malo
Danielle Malo McGill University

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