2010 - Fellow of the Royal Society of Canada Academy of Science
His main research concerns Mitochondrion, Caenorhabditis elegans, Mutant, Mutation and Genetics. Siegfried Hekimi combines subjects such as Oxidative stress, Superoxide dismutase and Reactive oxygen species with his study of Mitochondrion. His studies link Longevity with Caenorhabditis elegans.
His work in Mutant tackles topics such as Allele which are related to areas like Wild type, Period, Gene mutation, Daf-16 and Disorders of sex development. His work is dedicated to discovering how Mutation, Phenotype are connected with CLOCK, Gene interaction and Genetics of aging and other disciplines. In general Genetics, his work in Gene, Genetic recombination, Mitotic crossover and Ectopic recombination is often linked to Gene density linking many areas of study.
Siegfried Hekimi spends much of his time researching Caenorhabditis elegans, Genetics, Mutant, Cell biology and Mitochondrion. Within one scientific family, he focuses on topics pertaining to Mutation under Caenorhabditis elegans, and may sometimes address concerns connected to Cell cycle and Genetics of aging. His work carried out in the field of Mutant brings together such families of science as Caenorhabditis and RNA interference.
His Cell biology research incorporates themes from Electron transport chain and Gene expression, Transcriptional regulation. His study in Mitochondrion is interdisciplinary in nature, drawing from both Oxidative stress, Superoxide dismutase and Reactive oxygen species. His Oxidative stress study integrates concerns from other disciplines, such as Genetic model and Immunology.
His primary areas of investigation include Cell biology, Mitochondrion, Caenorhabditis elegans, Reactive oxygen species and Mitochondrial ROS. His Cell biology research is multidisciplinary, relying on both Cell and Gene expression. His Mitochondrion study incorporates themes from Endocrinology, Mutant, Internal medicine and Longevity.
As part of one scientific family, Siegfried Hekimi deals mainly with the area of Mutant, narrowing it down to issues related to the Oxidative stress, and often Mitochondrial respiratory chain. His research on Caenorhabditis elegans concerns the broader Genetics. Siegfried Hekimi works mostly in the field of Reactive oxygen species, limiting it down to topics relating to Superoxide and, in certain cases, Superoxide dismutase.
His primary scientific interests are in Mitochondrion, Cell biology, Reactive oxygen species, Signal transduction and Biochemistry. He has included themes like Coenzyme Q10, Premature ovarian failure and Internal medicine in his Mitochondrion study. His Cell biology course of study focuses on Superoxide and Electron transport chain and Antioxidant.
His work carried out in the field of Signal transduction brings together such families of science as Superoxide dismutase and Mutant. Siegfried Hekimi has included themes like Oxidative stress, Apoptosis and Gene expression in his Mutant study. His Paraquat research integrates issues from Cell signaling, Caenorhabditis elegans, Dose–response relationship, Vitamin C and Metabolism.
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The genetics of caloric restriction in Caenorhabditis elegans
Bernard Lakowski;Siegfried Hekimi.
Proceedings of the National Academy of Sciences of the United States of America (1998)
Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.
Jinliu Feng;Frédéric Bussière;Siegfried Hekimi.
Developmental Cell (2001)
Determination of life-span in Caenorhabditis elegans by four clock genes.
Bernard Lakowski;Siegfried Hekimi.
Taking a “good” look at free radicals in the aging process
Siegfried Hekimi;Jérôme Lapointe;Yang Wen.
Trends in Cell Biology (2011)
A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans
Wen Yang;Siegfried Hekimi.
PLOS Biology (2010)
Genetics and the Specificity of the Aging Process
Siegfried Hekimi;Leonard Guarente.
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans
Jeremy M. Van Raamsdonk;Siegfried Hekimi.
PLOS Genetics (2009)
Mutations in the Clk-1 Gene of Caenorhabditis Elegans Affect Developmental and Behavioral Timing
A Wong;P Boutis;S Hekimi.
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.
Jonathan J. Ewbank;Thomas M. Barnes;Bernard Lakowski;Marc Lussier.
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling.
Ying Wang;Robyn Branicky;Alycia Noë;Siegfried Hekimi.
Journal of Cell Biology (2018)
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