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Biology and Biochemistry

D-Index
69
Citations
24079
World Ranking
7266
National Ranking
557

Overview

David Gems is affiliated with University College London in the United Kingdom and has a research focus spanning biochemistry, genetics, and molecular biology. Their primary field of study is Aging, with specific attention to genetics and longevity in model organisms.

The scientist's recent publications include:

  • "Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo," 2022, Nature Metabolism
  • "The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm," 2021, Ageing Research Reviews
  • "The hyperfunction theory: An emerging paradigm for the biology of aging," 2022, Ageing Research Reviews
  • "C. elegans feed yolk to their young in a form of primitive lactation," 2021, Nature Communications
  • "Reproductive Suicide: Similar Mechanisms of Aging in C. elegans and Pacific Salmon," 2021, Frontiers in Cell and Developmental Biology

David Gems collaborates frequently with several researchers, including Carina Kern, Marina Ezcurra, João Pedro de Magalhães, Aihan Zhang, and Bruce Zhang. The frequency of these collaborations suggests an active research network focused on aging and related biological systems.

The scientist's frequent publication venues are diverse, with multiple papers appearing in the following:

  • Preprints.org
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Ageing Research Reviews
  • GeroScience
  • Nature Communications

David Gems' work covers a range of subfields related to aging biology:

  • Aging
  • Physiology
  • Endocrine and Autonomic Systems
  • Genetics
  • Molecular Biology

The core topics addressed in their research include:

  • Genetics, Aging, and Longevity in Model Organisms
  • Spaceflight effects on biology
  • Circadian rhythm and melatonin
  • Aging and Gerontology Research
  • Evolution and Genetic Dynamics
  • Epigenetics and DNA Methylation
  • Telomeres, Telomerase, and Senescence

Best Publications

  • Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

    David J. Clancy;David Gems;Lawrence G. Harshman;Sean Oldham

  • Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

    Colin Selman;Jennifer M A Tullet;Daniela Wieser;Elaine Elizabeth Irvine

  • Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

    David Gems;Amy J. Sutton;Mark L. Sundermeyer;Patrice S. Albert

  • Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

    Filipe Cabreiro;Catherine Au;Kit-Yi Leung;Nuria Vergara-Irigaray

  • Unraveling the biological roles of reactive oxygen species.

    Michael P. Murphy;Arne Holmgren;Nils Göran Larsson;Barry Halliwell

  • Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

    Camilla Burnett;Sara Valentini;Filipe Gomes Cabreiro;Martin Goss

  • Mechanisms of ageing: public or private?

    Linda Partridge;David Gems

  • Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

    David Gems;Linda Partridge

  • Interventions to Slow Aging in Humans: Are We Ready?

    Valter D. Longo;Adam Antebi;Andrzej Bartke;Nir Barzilai

  • Stress-response hormesis and aging: "that which does not kill us makes us stronger".

    David Gems;Linda Partridge

  • Sex and Death: What Is the Connection?

    Linda Partridge;David Gems;Dominic J. Withers

  • Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

    Colin Selman;Steven Lingard;Agharul I. Choudhury;Rachel L. Batterham

  • Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans.

    Timothy M. Bass;David Weinkove;Koen Houthoofd;David Gems

  • Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

    Ryan Doonan;Joshua J. McElwee;Filip Matthijssens;Glenda A. Walker

  • Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance

    Joshua J. McElwee;Eugene Schuster;Eric Blanc;James H. Thomas

  • Genetic, Behavioral and Environmental Determinants of Male Longevity in Caenorhabditis elegans

    David Gems;David Gems;Donald L. Riddle

  • Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?

    David Gems;Ryan Doonan

  • Dietary Restriction in Long-Lived Dwarf Flies

    David J. Clancy;David Gems;Ernst Hafen;Sally J. Leevers

  • Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

    Helena M. Cochemé;Caroline Quin;Stephen J. McQuaker;Filipe Cabreiro

  • Longevity in Caenorhabditis elegans reduced by mating but not gamete production

    David Gems;Donald L. Riddle

Frequent Co-Authors

Linda Partridge
Linda Partridge Max Planck Society
Janet M. Thornton
Janet M. Thornton European Bioinformatics Institute
Dominic J. Withers
Dominic J. Withers Imperial College London
Jacques R. Vanfleteren
Jacques R. Vanfleteren Ghent University
Claudio Franceschi
Claudio Franceschi University of Bologna
Colin Selman
Colin Selman University of Glasgow
Paul C. Driscoll
Paul C. Driscoll University College London
Mark Viney
Mark Viney University of Bristol
Donald L Riddle
Donald L Riddle University of Missouri
Jan Vijg
Jan Vijg Albert Einstein College of Medicine

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