His main research concerns Longevity, Genetics, Caenorhabditis elegans, Drosophila melanogaster and Oxidative damage. His Genetics study integrates concerns from other disciplines, such as Fecundity and Daf-2. His Caenorhabditis elegans research includes elements of Endocrinology, Wild type, Mutant, Internal medicine and Cell biology.
His Drosophila melanogaster study incorporates themes from Calorie restriction, Insulin Receptor Substrate Proteins, Insulin receptor substrate and Saccharomyces cerevisiae. His Oxidative damage study combines topics in areas such as Stress resistance, Reactive oxygen species, Toxicology and Neuroscience. David Gems focuses mostly in the field of Stress resistance, narrowing it down to topics relating to Model organism and, in certain cases, Insulin.
David Gems focuses on Caenorhabditis elegans, Longevity, Genetics, Cell biology and Ageing. His Caenorhabditis elegans research incorporates themes from Drosophila melanogaster, Senescence, Transcription factor and Insulin. His work carried out in the field of Longevity brings together such families of science as Zoology, Hermaphrodite, Bioinformatics and Phenotypic plasticity.
Genetics is frequently linked to Daf-2 in his study. His Cell biology research is multidisciplinary, relying on both Autophagy and Oxidative stress, Biochemistry. In his work, Oxidative damage and Metabolic rate is strongly intertwined with Nematode caenorhabditis elegans, which is a subfield of Ageing.
Caenorhabditis elegans, Cell biology, Yolk, Longevity and Disease are his primary areas of study. His study in Caenorhabditis elegans is interdisciplinary in nature, drawing from both Loss function, Glycolysis, Innate immune system, Immune system and Monocyte. His research integrates issues of Transcription factor, Insulin and Glutaminolysis in his study of Cell biology.
His Yolk research incorporates elements of Zoology and Semelparity and iteroparity, Reproduction. His Longevity research is included under the broader classification of Genetics. The Hygiene hypothesis research David Gems does as part of his general Disease study is frequently linked to other disciplines of science, such as Probiotic, therefore creating a link between diverse domains of science.
His scientific interests lie mostly in Caenorhabditis elegans, Longevity, Genetics, Senescence and Gene. He has researched Caenorhabditis elegans in several fields, including Pharynx, Bioinformatics, Ageing, Programmed cell death and Multiple causes of death. His Genetics study frequently links to adjacent areas such as Cell biology.
His biological study spans a wide range of topics, including Pleiotropy, Reproductive system, Gonad and Germline. He interconnects Cognitive science, Complex disease, Disease and Physiology in the investigation of issues within Senescence. His Transcriptional regulation study combines topics from a wide range of disciplines, such as Regulator, Oxidative stress, Mutant and Metabolism.
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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
David J. Clancy;David Gems;Lawrence G. Harshman;Sean Oldham.
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Colin Selman;Jennifer M A Tullet;Daniela Wieser;Elaine Elizabeth Irvine.
Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans
David Gems;Amy J. Sutton;Mark L. Sundermeyer;Patrice S. Albert.
Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
Filipe Cabreiro;Catherine Au;Kit-Yi Leung;Nuria Vergara-Irigaray.
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Camilla Burnett;Sara Valentini;Filipe Gomes Cabreiro;Martin Goss.
Unraveling the biological roles of reactive oxygen species.
Michael P. Murphy;Arne Holmgren;Nils Göran Larsson;Barry Halliwell.
Cell Metabolism (2011)
Mechanisms of aging: public or private?
Linda Partridge;David Gems.
Nature Reviews Genetics (2002)
Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts
David Gems;Linda Partridge.
Annual Review of Physiology (2013)
Sex and Death: What Is the Connection?
Linda Partridge;David Gems;Dominic J. Withers.
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans.
Timothy M. Bass;David Weinkove;Koen Houthoofd;David Gems.
Mechanisms of Ageing and Development (2007)
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