World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
23549
World Ranking
9986
National Ranking
763

Overview

Dominic J. Withers is affiliated with Imperial College London in the United Kingdom. Their research spans multiple fields with a focus on medicine and biochemistry, genetics, and molecular biology. Their work engages significantly with subfields such as molecular biology, physiology, surgery, cellular and molecular neuroscience, and genetics.

Withers's research topics cover a variety of important areas, including:

  • Pancreatic function and diabetes
  • Adipose tissue and metabolism
  • Telomeres, telomerase, and senescence
  • Neurotransmitter receptor influence on behavior
  • Genetics, aging, and longevity in model organisms
  • Epigenetics and DNA methylation
  • Treatment of major depression

Their recent publications reflect a focus on cellular aging, senescence, and neurological disorders. Selected recent papers include:

  • "Inhibition of IL-11 signalling extends mammalian healthspan and lifespan," 2024, Nature
  • "Galactose-modified duocarmycin prodrugs as senolytics," 2020, Aging Cell
  • "Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine," 2020, Molecular Psychiatry
  • "Detection of senescence using machine learning algorithms based on nuclear features," 2024, Nature Communications
  • "COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells," 2023, Nature Cell Biology

Their work has been published prominently in journals such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Endocrine Abstracts, Nature Cell Biology, and Diabetologia. They have contributed extensively to bioRxiv with eight publications in addition to multiple articles in these other venues.

Dominic J. Withers collaborates frequently with several researchers, including:

  • Jesús Gil
  • Elaine E. Irvine
  • Alex Montoya
  • Oliver Howes
  • Steven J. Millership

Across their career, Withers has contributed significantly to understanding molecular and cellular mechanisms underlying aging, metabolism, and neurological conditions, employing approaches from genetics to advanced imaging and machine learning.

Best Publications

  • Inhibition of food intake in obese subjects by peptide YY3-36.

    Rachel L Batterham;Mark A Cohen;Sandra M Ellis;Carel W Le Roux

  • Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

    Barbara T. Navé;D. Margriet Ouwens;Dominic J. Withers;Dario R. Alessi

  • Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

    Colin Selman;Jennifer M A Tullet;Daniela Wieser;Elaine Elizabeth Irvine

  • PHOSPHOINOSITIDE 3-KINASE : THE KEY SWITCH MECHANISM IN INSULIN SIGNALLING

    Peter R. Shepherd;Dominic J. Withers;Kenneth Siddle

  • Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

    Susan J. Broughton;Matthew D. W. Piper;Tomoatsu Ikeya;Timothy M. Bass

  • Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling

    Dominic J. Withers;Deborah J. Burks;Heather H. Towery;Shari L. Altamuro

  • mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

    Nicolás Herranz;Suchira Gallage;Massimiliano Mellone;Torsten Wuestefeld

  • Critical role for peptide YY in protein-mediated satiation and body-weight regulation

    Rachel L. Batterham;Helen Heffron;Saloni Kapoor;Joanna E. Chivers

  • Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

    Yoshiaki Kido;Deborah J. Burks;Dominic Withers;Jens C. Bruning

  • Sex and Death: What Is the Connection?

    Linda Partridge;David Gems;Dominic J. Withers

  • Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

    Colin Selman;Steven Lingard;Agharul I. Choudhury;Rachel L. Batterham

  • AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

    Marc Claret;Mark A. Smith;Rachel L. Batterham;Colin Selman

  • Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

    Lazaros C. Foukas;Marc Claret;Wayne Pearce;Klaus Okkenhaug;Klaus Okkenhaug

  • PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

    Rachel L. Batterham;Dominic H. ffytche;J. Miranda Rosenthal;Fernando O. Zelaya

  • IRS-2 pathways integrate female reproduction and energy homeostasis

    Deborah J. Burks;Jaime Font de Mora;Markus Schubert;Dominic J. Withers

  • A link between FTO, ghrelin, and impaired brain food-cue responsivity

    Efthimia Karra;Owen G. O’Daly;Agharul I. Choudhury;Ahmed Yousseif

  • Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo

    Stephen F. Previs;Dominic J. Withers;Jian-Ming Ren;Morris F. White

  • Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.

    Rohit N. Kulkarni;Zhi Li Wang;Ren Ming Wang;James D. Hurley

  • Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

    Mohsen Malehmir;Dominik Pfister;Suchira Gallage;Marta Szydlowska

  • The role of insulin receptor substrate 2 in hypothalamic and β cell function

    Agharul I. Choudhury;Helen Heffron;Mark A. Smith;Hind Al-Qassab

Frequent Co-Authors

Colin Selman
Colin Selman University of Glasgow
Linda Partridge
Linda Partridge Max Planck Society
Morris F. White
Morris F. White Boston Children's Hospital
Oliver D. Howes
Oliver D. Howes King's College London
Mark A. Ungless
Mark A. Ungless Imperial College London
Michael L. J. Ashford
Michael L. J. Ashford University of Dundee
Jesús Gil
Jesús Gil Imperial College London
David Carling
David Carling Imperial College London
Enrique Rozengurt
Enrique Rozengurt University of California, Los Angeles
Stephen R. Bloom
Stephen R. Bloom Imperial College London

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology or Biochemistry opens doors to a variety of roles in healthcare, research, and industry. For example, graduates may pursue specialties like health information management or medical coding, which play critical roles in the medical field.

If you’re interested in the administrative side of healthcare, exploring an him degree online can prepare you for positions in hospitals, insurance companies, and clinics. Such a degree often leads to careers like medical billing and coding. Wondering about medical.coding salary? Rates are competitive and often increase with certification and experience.

Not sure if this career suits you? Read about the is medical coding a good career to weigh the benefits and challenges of entering this field.

Beyond healthcare management, biochemistry backgrounds can support careers in nutrition science. Consider earning an online nutrition masters as a pathway to becoming a nutritionist or dietary consultant.

Online degree options make it easier than ever to grow your career and specialize your knowledge after finishing your studies in Biology or Biochemistry.

Best Scientists Citing Dominic J. Withers

Trending Scientists