World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
89
Citations
35704
World Ranking
1109
National Ranking
153

Medicine

D-Index
91
Citations
36466
World Ranking
11617
National Ranking
1103

Research.com Recognitions

  • 2016 - Member of Academia Europaea
  • 2005 - Fellow of the Royal Society of Edinburgh
  • 1971 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

W.H. Irwin McLean is affiliated with the University of Dundee in the United Kingdom, specializing in fields related to medicine and biochemistry, genetics, and molecular biology. Their research spans several subfields, including dermatology, immunology and allergy, molecular biology, emergency medical services, and public health, environmental, and occupational health.

Their work encompasses various topics, notably dermatology and skin diseases, allergic rhinitis and sensitization, telemedicine and telehealth implementation, asthma and respiratory diseases, gut microbiota and health, pediatric health and respiratory diseases, and primary care and health outcomes.

Recent publications by McLean include the following:

  • Gut microbiota development during infancy: Impact of introducing allergenic foods, 2021, Journal of Allergy and Clinical Immunology
  • Telemedicine Services During COVID-19: Considerations for Medically Underserved Populations, 2020, The Journal of Rural Health
  • Topical corticosteroids normalize both skin and systemic inflammatory markers in infant atopic dermatitis, 2020, British Journal of Dermatology
  • Bathing frequency is associated with skin barrier dysfunction and atopic dermatitis at three months of age, 2020, The Journal of Allergy and Clinical Immunology In Practice
  • Development of a Corneal Bioluminescence Mouse for Real-Time In Vivo Evaluation of Gene Therapies, 2020, Translational Vision Science & Technology

Frequent co-authors collaborating with McLean include:

  • Tom Marrs
  • Michael R. Perkin
  • Kirsty Logan
  • Suzana Radulović
  • Serge A. Versteeg

McLean's research appears regularly in notable publication venues such as:

  • Journal of Allergy and Clinical Immunology
  • The Journal of Rural Health
  • British Journal of Dermatology
  • The Journal of Allergy and Clinical Immunology In Practice
  • Translational Vision Science & Technology

The scholar's career includes recognition through several awards, including:

  • Member of Academia Europaea (2016)
  • Fellow of the Royal Society of Edinburgh (2005)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1971)

Best Publications

  • Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

    Colin N A Palmer;Alan D Irvine;Ana Terron-Kwiatkowski;Yiwei Zhao

  • Filaggrin Mutations Associated with Skin and Allergic Diseases

    Alan D Irvine;W H Irwin McLean;Donald Y M Leung;Donald Y M Leung

  • Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris

    Frances J D Smith;Alan D Irvine;Ana Terron-Kwiatkowski;Aileen Sandilands

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    Lam C. Tsoi;Sarah L. Spain;Sarah L. Spain;Jo Knight;Eva Ellinghaus;Eva Ellinghaus

  • A Genome-Wide Association Study Identifies New Psoriasis Susceptibility Loci and an Interaction Between HLA-C and ERAP1

    Amy Strange;Francesca Capon;Chris C A Spencer

  • Filaggrin in the frontline: role in skin barrier function and disease.

    Aileen Sandilands;Calum Sutherland;Alan D. Irvine;Alan D. Irvine;W. H. Irwin McLean

  • Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

    Eric L. Simpson;Joanne R. Chalmers;Jon M. Hanifin;Kim S. Thomas

  • Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.

    Aileen Sandilands;Ana Terron-Kwiatkowski;Peter R Hull;Gráinne M O'Regan

  • Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

    Stephan Weidinger;Thomas Illig;Hansjörg Baurecht;Alan D. Irvine

  • Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

    Lavinia Paternoster;Marie Standl;Johannes Waage;Hansjoerg Baurecht

  • One remarkable molecule: Filaggrin

    Sara J. Brown;W. H. Irwin McLean

  • Filaggrin in atopic dermatitis

    Grainne M. O'Regan;Aileen Sandilands;W.H. Irwin McLean;Alan D. Irvine;Alan D. Irvine

  • Intermediate filament proteins and their associated diseases.

    M Bishr Omary;Pierre A Coulombe;W H Irwin McLean

  • Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

    Sara J. Brown;Sara J. Brown;Sara J. Brown;Yuka Asai;Heather J. Cordell;Linda E. Campbell

  • A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

    Padraic G Fallon;Takashi Sasaki;Aileen Sandilands;Linda E Campbell

  • Filaggrin mutations, atopic eczema, hay fever, and asthma in children

    Stephan Weidinger;Maureen O'Sullivan;Thomas Illig;Hansjoerg Baurecht

  • The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study

    John Henderson;Kate Northstone;Simon P. Lee;Haihui Liao

  • Null Mutations in the Filaggrin Gene (FLG) Determine Major Susceptibility to Early-Onset Atopic Dermatitis that Persists into Adulthood

    Jonathan N W N Barker;Colin N A Palmer;Yiwei Zhao;Haihui Liao

  • The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases

    Ildiko Szeverenyi;Andrew J. Cassidy;Cheuk Wang Chung;Bernett T.K. Lee

  • Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome

    Dawn H. Siegel;Gabrielle H.S. Ashton;Homero G. Penagos;James V. Lee

Frequent Co-Authors

Alan D. Irvine
Alan D. Irvine Trinity College Dublin
Frances J.D. Smith
Frances J.D. Smith University of Dundee
John A. McGrath
John A. McGrath King's College London
Colin N. A. Palmer
Colin N. A. Palmer University of Dundee
Jouni Uitto
Jouni Uitto Thomas Jefferson University
Masashi Akiyama
Masashi Akiyama Nagoya University
Hiroshi Shimizu
Hiroshi Shimizu Hokkaido University
Robin A.J. Eady
Robin A.J. Eady St Thomas' Hospital
Stephan Weidinger
Stephan Weidinger Kiel University
Jonathan Barker
Jonathan Barker King's College London

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