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Junichi Fujii

Junichi Fujii

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
21366
World Ranking
5288
National Ranking
344

Overview

Junichi Fujii is affiliated with Yamagata University in Japan and has a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their work covers several subfields including molecular biology, pulmonary and respiratory medicine, nutrition and dietetics, biochemistry, and cancer research.

The main topics addressed in Fujii's research involve ferroptosis and cancer prognosis, redox biology and oxidative stress, vitamin C and antioxidants research, cancer, lipids and metabolism, RNA modifications and cancer, epigenetics and DNA methylation, and sulfur compounds in biology.

Fujii's recent scientific papers include:

  • Superoxide Radicals in the Execution of Cell Death (2022, Antioxidants)
  • Erythrocytes as a preferential target of oxidative stress in blood (2021, Free Radical Research)
  • Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation (2021, Archives of Biochemistry and Biophysics)
  • Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction (2021, Nitric Oxide)
  • Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs) (2020, Free Radical Research)

Frequent co-authors collaborating with Fujii are:

  • Takujiro Homma
  • Sho Kobayashi
  • Tsukasa Osaki
  • Satoshi Miyata
  • Ken-ichi Yamada

Fujii's research is regularly published in several scientific journals. The main venues include:

  • Free Radical Research
  • Antioxidants
  • Molecules
  • Free Radical Biology and Medicine
  • Journal of Clinical Biochemistry and Nutrition

The body of work contributed by Fujii demonstrates an interdisciplinary approach that connects molecular mechanisms of oxidative stress with cancer biology and metabolism, emphasizing biochemical pathways relevant to cell death mechanisms like ferroptosis.

Best Publications

  • Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia

    J Fujii;K Otsu;F Zorzato;S de Leon

  • Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

    F Zorzato;J Fujii;K Otsu;M Phillips

  • Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

    D H MacLennan;C Duff;F Zorzato;J Fujii

  • Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein.

    Junichi Fujii;Yoshitaka Ikeda

  • Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice

    Xiangchun Wang;Shinya Inoue;Jianguo Gu;Eiji Miyoshi

  • Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

    C.J. Harvey;R.K. Thimmulappa;A. Singh;D.J. Blake

  • Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells.

    H. Kaneto;J. Fujii;Han Geuk Seo;K. Suzuki

  • A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia.

    Elizabeth F. Gillard;Kinya Otsu;Junichi Fujii;Vijay K. Khanna

  • Inactivation of glutathione peroxidase by nitric oxide. Implication for cytotoxicity.

    Michio Asahi;Junichi Fujii;Keiichiro Suzuki;Han Geuk Seo

  • Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.

    Ryozo Nagai;Angel Zarain-Herzberg;Christopher J. Brandl;Junichi Fujii

  • Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction.

    Hideaki Kaneto;Junichi Fujii;Theingi Myint;Nobuko Miyazawa

  • Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system

    Junichi Fujii;Yoshihito Iuchi;Futoshi Okada

  • Complete complementary DNA-derived amino acid sequence of canine cardiac phospholamban.

    J Fujii;A Ueno;K Kitano;S Tanaka

  • Active glycation in neurofibrillary pathology of Alzheimer disease: Nε-(Carboxymethyl) lysine and hexitol-lysine

    Rudy J Castellani;Peggy L.R Harris;Lawrence M Sayre;Junichi Fujii

  • Induction of apoptotic cell death by methylglyoxal and 3-deoxyglucosone in macrophage-derived cell lines.

    Ayako Okado;Yoshimi Kawasaki;Yukiko Hasuike;Yukiko Hasuike;Motoko Takahashi

  • Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues.

    Junichi Fujii;Yoshihito Iuchi;Shingo Matsuki;Tatsuya Ishii

  • Peroxiredoxin IV is a secretable protein with heparin-binding properties under reduced conditions.

    Ayako Okado-Matsumoto;Akio Matsumoto;Junichi Fujii;Naoyuki Taniguchi

  • Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.

    Yoshihito Iuchi;Futoshi Okada;Satoshi Tsunoda;Noriko Kibe

  • Suppression of antioxidative enzyme expression by transforming growth factor-beta 1 in rat hepatocytes.

    Y. Kayanoki;J. Fujii;K. Suzuki;S. Kawata

  • Roles of Antioxidative Enzymes in Wound Healing

    Toshihiro Kurahashi;Junichi Fujii

Frequent Co-Authors

Naoyuki Taniguchi
Naoyuki Taniguchi Osaka University
Futoshi Okada
Futoshi Okada Tottori University
Keiichiro Suzuki
Keiichiro Suzuki Hyogo College of Medicine
David H. MacLennan
David H. MacLennan University of Toronto
Eiji Miyoshi
Eiji Miyoshi Osaka University
Takenobu Kamada
Takenobu Kamada Osaka University
Francesco Zorzato
Francesco Zorzato University of Ferrara
Koji Uchida
Koji Uchida University of Tokyo
Han Geuk Seo
Han Geuk Seo Konkuk University
Norio Niikawa
Norio Niikawa Health Sciences University of Hokkaido

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