World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
17564
World Ranking
7364
National Ranking
496

Overview

Jianguo Gu is affiliated with Tohoku Medical and Pharmaceutical University in Japan. Their research primarily focuses on the intersection of biochemistry, genetics, and molecular biology, with significant contributions to medicine. Jianguo Gu's work spans several subfields including molecular biology, immunology, organic chemistry, mechanical engineering, and radiology, nuclear medicine, and imaging, reflecting a multidisciplinary approach to scientific investigation.

The main topics addressed in Jianguo Gu's research include glycosylation and glycoproteins, galectins and cancer biology, monoclonal and polyclonal antibodies, immune cell function and interaction, cell adhesion molecules, carbohydrate chemistry and synthesis, as well as manufacturing processes and optimization. This breadth of topics indicates a focus on molecular and cellular processes relevant to disease mechanisms and therapeutic strategies.

Their publications have appeared frequently in the following venues:

  • Journal of Biological Chemistry
  • Biochimica et Biophysica Acta (BBA) - General Subjects
  • The International Journal of Advanced Manufacturing Technology
  • Organic Letters
  • Scientific Reports

Jianguo Gu has collaborated regularly with other researchers in the field. Frequent co-authors include Tomohiko Fukuda, Tomoya Isaji, Wenzhe Li, Yuhan Sun, and Wanli Song, indicating ongoing partnerships and contributions within a research network.

Among Jianguo Gu's recent papers are:

  • "Loss of core fucosylation enhances the anticancer activity of cytotoxic T lymphocytes by increasing PD-1 degradation," 2020, European Journal of Immunology
  • "Integrin β1 in Pancreatic Cancer: Expressions, Functions, and Clinical Implications," 2022, Cancers
  • "TM4SF1 promotes esophageal squamous cell carcinoma metastasis by interacting with integrin α6," 2022, Cell Death and Disease
  • "Core Fucosylation of Intestinal Epithelial Cells Protects Against Salmonella Typhi Infection via Up-Regulating the Biological Antagonism of Intestinal Microbiota," 2020, Frontiers in Microbiology
  • "α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma," 2021, Biochimica et Biophysica Acta (BBA) - General Subjects

Best Publications

  • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

    Masahito Tamura;Jianguo Gu;Jianguo Gu;Kazue Matsumoto;Kazue Matsumoto;Shin-ichi Aota;Shin-ichi Aota

  • Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

    Katrina Podsypanina;Lora Hedrick Ellenson;Adriana Nemes;Jianguo Gu

  • Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten

    Jianguo Gu;Masahito Tamura;Roumen Pankov;Erik H.J. Danen

  • Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.

    Masahito Tamura;Jianguo Gu;Takahisa Takino;Kenneth M. Yamada

  • Tumor Suppressor PTEN Inhibits Integrin- and Growth Factor–mediated Mitogen-activated Protein (MAP) Kinase Signaling Pathways

    Jianguo Gu;Masahito Tamura;Kenneth M. Yamada

  • PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway *

    Masahito Tamura;Jianguo Gu;Erik H.J. Danen;Takahisa Takino

  • Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice

    Xiangchun Wang;Shinya Inoue;Jianguo Gu;Eiji Miyoshi

  • Functional roles of N-glycans in cell signaling and cell adhesion in cancer.

    Yan-Yang Zhao;Motoko Takahashi;Jian-Guo Gu;Eiji Miyoshi

  • Core Fucosylation Regulates Epidermal Growth Factor Receptor-mediated Intracellular Signaling

    Xiangchun Wang;Jianguo Gu;Hideyuki Ihara;Eiji Miyoshi

  • Fucosylated haptoglobin is a novel marker for pancreatic cancer : A detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation

    Noriko Okuyama;Yoshihito Ide;Miyako Nakano;Tsutomu Nakagawa

  • Branched N-glycans regulate the biological functions of integrins and cadherins.

    Yanyang Zhao;Yuya Sato;Tomoya Isaji;Tomohiko Fukuda

  • Regulation of integrin functions by N-glycans.

    Jianguo Gu;Naoyuki Taniguchi

  • PTEN Gene and Integrin Signaling in Cancer

    Masahito Tamura;Jianguo Gu;Huan Tran;Kenneth M. Yamada

  • Laminin-10/11 and Fibronectin Differentially Regulate Integrin- dependent Rho and Rac Activation via p130Cas-CrkII-DOCK180 Pathway

    Jianguo Gu;Yasuhiro Sumida;Noriko Sanzen;Kiyotoshi Sekiguchi

  • Introduction of Bisecting GlcNAc into Integrin α5β1 Reduces Ligand Binding and Down-regulates Cell Adhesion and Cell Migration

    Tomoya Isaji;Jianguo Gu;Ryoko Nishiuchi;Yanyang Zhao

  • Purification and characterization of UDP-N-acetylglucosamine: alpha-6-D-mannoside beta 1-6N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase V) from a human lung cancer cell line.

    Jianguo Gu;Atsushi Nishikawa;Nobuo Tsuruoka;Masao Ohno

  • Modulation of E-cadherin function and dysfunction by N-glycosylation.

    Salomé S. Pinho;Raquel Seruca;Fátima Gärtner;Yoshiki Yamaguchi

  • Biochemical visualization of cell surface molecular clustering in living cells

    Norihiro Kotani;Norihiro Kotani;Jianguo Gu;Tomoya Isaji;Keiko Udaka

  • Carbohydrate Binding Specificity of a Fucose-specific Lectin from Aspergillus oryzae: A NOVEL PROBE FOR CORE FUCOSE

    Kengo Matsumura;Katsuya Higashida;Hiroki Ishida;Yoji Hata

  • Relationship between Elevated FX Expression and Increased Production of GDP-l-Fucose, a Common Donor Substrate for Fucosylation in Human Hepatocellular Carcinoma and Hepatoma Cell Lines

    Katsuhisa Noda;Eiji Miyoshi;Jianguo Gu;Cong-Xiao Gao

Frequent Co-Authors

Naoyuki Taniguchi
Naoyuki Taniguchi Osaka University
Eiji Miyoshi
Eiji Miyoshi Osaka University
Koichi Honke
Koichi Honke Kōchi University
Yoshinao Wada
Yoshinao Wada Osaka Women's and Children's Hospital
Kenneth M. Yamada
Kenneth M. Yamada National Institutes of Health
Kiyotoshi Sekiguchi
Kiyotoshi Sekiguchi Osaka University
Yuguang Du
Yuguang Du Chinese Academy of Sciences
Celso A. Reis
Celso A. Reis University of Porto
Raquel Seruca
Raquel Seruca University of Porto
Mitsuo Satoh
Mitsuo Satoh Kyowa Kirin (Japan)

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