Takuji Shirasawa

Overview

Best Publications

• Inhibition of autophagy in the heart induces age-related cardiomyopathy.

  Manabu Taneike;Osamu Yamaguchi;Atsuko Nakai;Shungo Hikoso

  573
  Citations

• Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1.

  Takumi Satoh;Kunio Kosaka;Ken Itoh;Akira Kobayashi

  528
  Citations

• Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration.

  Yutaka Imamura;Setsuko Noda;Kouhei Hashizume;Kei Shinoda

  484
  Citations

• Neurotoxicity and Physicochemical Properties of Aβ Mutant Peptides from Cerebral Amyloid Angiopathy: IMPLICATION FOR THE PATHOGENESIS OF CEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE

  Kazuma Murakami;Kazuhiro Irie;Akira Morimoto;Hajime Ohigashi

  321
  Citations

• SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease.

  Kazuma Murakami;Nakaba Murata;Yoshihiro Noda;Shoichi Tahara

  305
  Citations

• μ1B, a novel adaptor medium chain expressed in polarized epithelial cells1

  Hiroshi Ohno;Takuya Tomemori;Fubito Nakatsu;Yasushi Okazaki

  304
  Citations

• Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans.

  Juewon Kim;Mayumi Takahashi;Takahiko Shimizu;Takuji Shirasawa

  299
  Citations

• Oxidative stress causes heart failure with impaired mitochondrial respiration.

  Hidetoshi Nojiri;Takahiko Shimizu;Masabumi Funakoshi;Osamu Yamaguchi

  294
  Citations

• Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues.

  T Tomiyama;S Asano;Y Furiya;T Shirasawa

  226
  Citations

• Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells.

  Yasutaka Ikeda;Shinji Tsuji;Akira Satoh;Masaharu Ishikura

  225
  Citations

• Analysis of the Secondary Structure of β-Amyloid (Aβ42) Fibrils by Systematic Proline Replacement

  Akira Morimoto;Kazuhiro Irie;Kazuma Murakami;Yuichi Masuda

  217
  Citations

• Formation and Stabilization Model of the 42-mer Aβ Radical: Implications for the Long-Lasting Oxidative Stress in Alzheimer's Disease

  Kazuma Murakami;Kazuhiro Irie;Hajime Ohigashi;Hideyuki Hara

  216
  Citations

• Biological Significance of Isoaspartate and Its Repair System

  Takahiko Shimizu;Yasuji Matsuoka;Takuji Shirasawa

  212
  Citations

• Senescence Marker Protein-30 Knockout Mouse Liver Is Highly Susceptible to Tumor Necrosis Factor-α- and Fas-Mediated Apoptosis

  Akihito Ishigami;Toshiko Fujita;Setsuko Handa;Takuji Shirasawa

  210
  Citations

• Cytoplasmic superoxide causes bone fragility owing to low‐turnover osteoporosis and impaired collagen cross‐linking

  Hidetoshi Nojiri;Yoshitomo Saita;Daichi Morikawa;Keiji Kobayashi

  206
  Citations

• Synthesis, aggregation, neurotoxicity, and secondary structure of various Aβ1–42 mutants of familial Alzheimer's disease at positions 21–23

  Kazuma Murakami;Kazuhiro Irie;Akira Morimoto;Hajime Ohigashi

  193
  Citations

• Deficiency in Protein l-Isoaspartyl Methyltransferase Results in a Fatal Progressive Epilepsy

  Akihiro Yamamoto;Hideyuki Takagi;Daisuke Kitamura;Hozumi Tatsuoka

  183
  Citations

• CuZn-SOD Deficiency Causes ApoB Degradation and Induces Hepatic Lipid Accumulation by Impaired Lipoprotein Secretion in Mice

  Satoshi Uchiyama;Takahiko Shimizu;Takuji Shirasawa

  180
  Citations

• Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51.

  Jin Yan;Hidehito Kuroyanagi;Asato Kuroiwa;Yo Ichi Matsuda

  175
  Citations

• Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration.

  Masato Koike;Hidetoshi Nojiri;Yusuke Ozawa;Kenji Watanabe

  162
  Citations