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D-Index & Metrics

Biology and Biochemistry

D-Index
92
Citations
38450
World Ranking
2180
National Ranking
1179

Overview

Steven Clarke is affiliated with the University of California, Los Angeles in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad domains, Clarke focuses on specialties including Molecular Biology, Oncology, Biochemistry, Biotechnology, and Surgery.

The scientist's scholarly output includes studies covering significant topics such as Epigenetics and DNA Methylation, Cancer-related Gene Regulation, Cancer Research and Treatments, Peptidase Inhibition and Analysis, Mitochondrial Function and Pathology, Amino Acid Enzymes and Metabolism, and Cancer-related Molecular Pathways.

Among their recent published papers are the following:

  • Molecular damage in aging, 2021, Nature Aging
  • Linkage of methionine addiction, histone lysine hypermethylation, and malignancy, 2022, iScience
  • Extent and Instability of Trimethylation of Histone H3 Lysine Increases With Degree of Malignancy and Methionine Addiction, 2021, Cancer Genomics & Proteomics
  • Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation, 2022, Frontiers in Oncology
  • Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity, 2022, Diabetes

Clarke frequently collaborates with other researchers, including Troy L. Lowe, Yusuke Aoki, Robert M. Hoffman, Jun Yamamoto, and Sachiko Inubushi. These collaborations have resulted in multiple joint publications and contributions to the scientific community.

The scientist often publishes in prominent venues such as the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Nature Aging, and iScience.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Protein Arginine Methylation in Mammals: Who, What, and Why

    Mark T. Bedford;Steven G. Clarke

  • Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

    T Geiger;S Clarke

  • Protein isoprenylation and methylation at carboxyl-terminal cysteine residues.

    Steven Clarke

  • Human PAD4 regulates histone arginine methylation levels via demethylimination.

    Yanming Wang;Joanna Wysocka;Joyce Sayegh;Young-Ho Lee

  • Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

    A E Roher;J D Lowenson;S Clarke;C Wolkow

  • beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

    Alex E. Roher;Jonathan D. Lowenson;Steven Clarke;Amina S. Woods

  • RNA and Protein Interactions Modulated by Protein Arginine Methylation

    Jonathan D. Gary;Steven Clarke

  • Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins.

    R C Stephenson;S Clarke

  • Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes.

    R.M. Kagan;S. Clarke

  • The Mammalian Immediate-early TIS21 Protein and the Leukemia-associated BTG1 Protein Interact with a Protein-arginine N-Methyltransferase

    Wey Jinq Lin;Jonathan D. Gary;Melody C. Yang;Steven Clarke

  • PRMT1 Is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells

    Jie Tang;Adam Frankel;Robert J. Cook;Sangduk Kim

  • The size and detergent binding of membrane proteins.

    S Clarke

  • Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

    Steven Clarke;Joseph P. Vogel;Robert J. Deschenes;Jeffry Stock

  • PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins.

    Tina L. Branscombe;Adam Frankel;Jin-Hyung Lee;Jeffry R. Cook

  • Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins

    Steven Clarke

  • The Novel Human Protein Arginine N-Methyltransferase PRMT6 Is a Nuclear Enzyme Displaying Unique Substrate Specificity *

    Adam Frankel;Neelu Yadav;Jaeho Lee;Tina L. Branscombe

  • PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation

    Jie Tang;Jonathan D. Gary;Steven Clarke;Harvey R. Herschman

  • Protein carboxyl methyltransferases: two distinct classes of enzymes.

    Steven Clarke

  • Aging as war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair.

    Steven Clarke

Frequent Co-Authors

Julian P. Whitelegge
Julian P. Whitelegge University of California, Los Angeles
Mark T. Bedford
Mark T. Bedford The University of Texas MD Anderson Cancer Center
Alex E. Roher
Alex E. Roher Banner Health
Harvey R. Herschman
Harvey R. Herschman University of California, Los Angeles
Joseph A. Loo
Joseph A. Loo University of California, Los Angeles
Stephen G. Young
Stephen G. Young University of California, Los Angeles
David Eisenberg
David Eisenberg Harvard University
Kym F. Faull
Kym F. Faull University of California, Los Angeles
Michael R. Sawaya
Michael R. Sawaya University of California, Los Angeles
Mark J. Mamula
Mark J. Mamula Yale University

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