Alex E. Roher

Best Publications

• RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

  Shi Du Yan;Xi Chen;Jin Fu;Ming Chen

  2912
  Citations

• Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer’s Disease

  Lih Fen Lue;Yu Min Kuo;Alex E. Roher;Libuse Brachova

  2094
  Citations

• Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

  A E Roher;J D Lowenson;S Clarke;C Wolkow

  961
  Citations

• Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

  Yu Min Kuo;Mark R. Emmerling;Carmen Vigo-Pelfrey;Timothy C. Kasunic

  863
  Citations

• beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

  Alex E. Roher;Jonathan D. Lowenson;Steven Clarke;Amina S. Woods

  782
  Citations

• Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid Cu-DEPENDENT CATALYTIC CONVERSION OF DOPAMINE, CHOLESTEROL, AND BIOLOGICAL REDUCING AGENTS TO NEUROTOXIC H2O2

  Carlos Opazo;Xudong Huang;Robert A. Cherny;Robert D. Moir

  780
  Citations

• Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease

  Alex E. Roher;Michael O. Chaney;Yu Min Kuo;Scott D. Webster

  722
  Citations

• Cerebral Amyloid Angiopathy: Amyloid β Accumulates in Putative Interstitial Fluid Drainage Pathways in Alzheimer's Disease

  Roy O. Weller;Adrian Massey;Tracey A. Newman;Margaret Hutchings

  668
  Citations

• Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

  Shi Du Yan;Huaijie Zhu;Jin Fu;Shi Fang Yan

  663
  Citations

• An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

  Shi Du Yan;Jin Fu;Claudio Soto;Xi Chen

  525
  Citations

• Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

  Thomas G. Beach;Charles H. Adler;Lucia I. Sue;Geidy Serrano

  477
  Citations

• Evidence for Seeding of β-Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in β-Amyloid Precursor Protein-Transgenic Mice

  Michael D. Kane;William J. Lipinski;Michael J. Callahan;Feng Bian

  471
  Citations

• Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

  Alex E. Roher;Chera L. Esh;Tyler A. Kokjohn;Eduardo Miguel Castaño

  466
  Citations

• Elevated Low-Density Lipoprotein in Alzheimer's Disease Correlates with Brain Aβ 1–42 Levels

  Yu-Min Kuo;Mark R. Emmerling;Charles L. Bisgaier;Arnold D. Essenburg

  454
  Citations

• Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

  Shi Du Yan;Huaijie Zhu;Aiping Zhu;Adam Golabek

  445
  Citations

• RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice

  Ottavio Arancio;Hui Ping Zhang;Xi Chen;Chang Lin

  434
  Citations

• Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

  Alex E. Roher;Chera Esh;Tyler A. Kokjohn;Walter Kalback

  389
  Citations

• Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

  Dana Giulian;Lanny J. Haverkamp;J. H. Yu;William Karshin

  360
  Citations

• The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007.

  Thomas G. Beach;Lucia I. Sue;Douglas G. Walker;Alex E. Roher

  356
  Citations

• Increased Aβ Peptides and Reduced Cholesterol and Myelin Proteins Characterize White Matter Degeneration in Alzheimer's Disease†

  Alex E. Roher;Nicole Weiss;Tyler A. Kokjohn;Yu Min Kuo

  347
  Citations