Michael R. Sawaya

What is he best known for?

The fields of study he is best known for:

• Enzyme
• Gene
• DNA

His primary areas of study are Biochemistry, Protein structure, Biophysics, Peptide sequence and Amyloid. Biochemistry is often connected to Viral replication in his work. His studies in Protein structure integrate themes in fields like Structural biology, Genetics, Crystallography, Crystal structure and Alzheimer's disease.

His studies deal with areas such as Steric effects, Scaffold protein, Sequence, Side chain and Binding site as well as Biophysics. His Peptide sequence research incorporates elements of P3 peptide, Amylin, Amyloid disease, Biochemistry of Alzheimer's disease and Insulin. Michael R. Sawaya has included themes like Fibril, Protein aggregation, Protein Data Bank and Peptide in his Amyloid study.

His most cited work include:

• Structure of the cross-beta spine of amyloid-like fibrils. (1691 citations)
• Atomic structures of amyloid cross-beta spines reveal varied steric zippers. (1674 citations)
• Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels (1181 citations)

What are the main themes of his work throughout his whole career to date?

Michael R. Sawaya mainly investigates Biochemistry, Biophysics, Crystallography, Protein structure and Amyloid. Michael R. Sawaya frequently studies issues relating to Stereochemistry and Biochemistry. His research on Biophysics also deals with topics like

• Zipper most often made with reference to Steric effects,
• Protein subunit that connect with fields like Organelle, Bacterial microcompartment and Carboxysome.

His study in Peptide extends to Crystallography with its themes. His study ties his expertise on Protein folding together with the subject of Protein structure. His Amyloid study integrates concerns from other disciplines, such as Fibril, Structural biology, P3 peptide and Protein aggregation.

He most often published in these fields:

• Biochemistry (35.21%)
• Biophysics (31.36%)
• Crystallography (26.92%)

What were the highlights of his more recent work (between 2018-2021)?

• Biophysics (31.36%)
• Peptide (13.91%)
• Fibril (18.93%)

In recent papers he was focusing on the following fields of study:

Biophysics, Peptide, Fibril, Crystallography and Amyloid are his primary areas of study. His Biophysics research is multidisciplinary, incorporating elements of Mutation, In vitro, Dementia and Atrophy. The concepts of his Peptide study are interwoven with issues in Structural biology, Genetics, Low complexity and Stereochemistry.

His Fibril study also includes fields such as

• Protein aggregation which is related to area like Protein structure,
• Neurodegeneration, which have a strong connection to Amyloid fibril, Protein filament and Green tea. His study in Crystallography is interdisciplinary in nature, drawing from both Visualization and Femtosecond. His Amyloid research is multidisciplinary, incorporating perspectives in RNA, Nucleoprotein and Viral replication.

Between 2018 and 2021, his most popular works were:

• Cryo-EM structures of four polymorphic TDP-43 amyloid cores. (65 citations)
• Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs (41 citations)
• Non-proteinaceous hydrolase comprised of a phenylalanine metallo-supramolecular amyloid-like structure. (28 citations)

In his most recent research, the most cited papers focused on:

• Enzyme
• Gene
• DNA

His main research concerns Fibril, Biophysics, Amyloid, Mutation and Protein structure. His Fibril research includes themes of Epitope, Chemical biology, Protein stability and Cognitive decline. His research in Biophysics focuses on subjects like Steric effects, which are connected to Protein secondary structure and Crystallography.

Michael R. Sawaya has researched Amyloid in several fields, including Ribonucleoprotein, Structural biology and Hydrogen bond. His work in Structural biology addresses subjects such as Centrosymmetry, which are connected to disciplines such as Peptide. Michael R. Sawaya studied Protein structure and Protein aggregation that intersect with Point mutation and Protein folding.