World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
50118
World Ranking
1488
National Ranking
845

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors
  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Charles G. Glabe is affiliated with the University of California, Irvine in the United States. Their research primarily focuses on the investigation of Alzheimer's disease, with significant contributions in related fields such as molecular biology and medicine.

The scientist's work encompasses a range of topics including:

  • Alzheimer's disease research and treatments
  • Monoclonal and Polyclonal Antibodies Research
  • Protein Structure and Dynamics
  • Computational Drug Discovery Methods
  • Cholinesterase and Neurodegenerative Diseases
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Nuclear Receptors and Signaling

Research by Charles G. Glabe has been published extensively in venues such as:

  • Alzheimer's & Dementia
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Archives of Physiology and Biochemistry
  • Acta Neuropathologica Communications

Frequent coauthors in their scholarly work include:

  • Emilie L. Castranio
  • Michelle E. Ehrlich
  • Jorge Mauricio Reyes-Ruiz
  • Philip L. Felgner
  • Rie Nakajima

Selected recent papers authored or coauthored by Charles G. Glabe cover various aspects of Alzheimer's disease and related molecular mechanisms:

  • Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease, 2022, Alzheimer's & Dementia
  • Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease, 2021, Acta Neuropathologica Communications
  • Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils, 2023, Proceedings of the National Academy of Sciences
  • Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease, 2020, Journal of Biological Chemistry
  • Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer's Disease Mouse Model, 2022, Journal of Alzheimer's Disease

Their main fields of study include medicine and biochemistry, genetics, and molecular biology, with notable subfields such as physiology, molecular biology, radiology, nuclear medicine and imaging, cellular and molecular neuroscience, and computational theory and mathematics.

Charles G. Glabe has received recognitions such as being named a Fellow of the National Academy of Inventors in 2020, and a Fellow of the American Association for the Advancement of Science (AAAS) in 2008.

Best Publications

  • Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

    Rakez Kayed;Elizabeth Head;Jennifer L. Thompson;Theresa M. McIntire

  • A specific amyloid-|[beta]| protein assembly in the brain impairs memory

    Sylvain Lesné;Ming Teng Koh;Linda Kotilinek;Rakez Kayed

  • Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

    Fusheng Yang;Giselle P. Lim;Giselle P. Lim;Aynun N. Begum;Aynun N. Begum;Oliver J. Ubeda;Oliver J. Ubeda

  • Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

    Christian J. Pike;Debra Burdick;Andrea J. Walencewicz;Charles G. Glabe

  • Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

    Debra Burdick;Brian Soreghan;Michael Kwon;Joseph Kosmoski

  • Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.

    Angelo Demuro;Erene Mina;Rakez Kayed;Saskia C. Milton

  • In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity ☆

    Christian J. Pike;Andrea J. Walencewicz;Charles G. Glabe;Carl W. Cotman

  • Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

    Rakez Kayed;Yuri Sokolov;Brian Edmonds;Theresa M. McIntire

  • Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity CORRELATION WITH CELL-FREE HYDROGEN PEROXIDE PRODUCTION AND METAL REDUCTION

    Xudong Huang;Math P. Cuajungco;Craig S. Atwood;Mariana A. Hartshorn

  • Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

    Christian J. Pike;Andrea J. Walencewicz-Wasserman;Joseph Kosmoski;David H. Cribbs

  • Structural classification of toxic amyloid oligomers.

    Charles G. Glabe

  • Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

    Marielle Aulikki Wälti;Francesco Ravotti;Hiromi Arai;Charles G. Glabe

  • Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

    Rakez Kayed;Elizabeth Head;Floyd Sarsoza;Tommy Saing

  • Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct

    Mihaela Necula;Rakez Kayed;Saskia Milton;Charles G. Glabe

  • Common mechanisms of amyloid oligomer pathogenesis in degenerative disease.

    Charles G. Glabe

  • Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons.

    Atul Deshpande;Erene Mina;Charles Glabe;Jorge Busciglio

  • Atomic view of a toxic amyloid small oligomer.

    Arthur Laganowsky;Cong Liu;Michael R. Sawaya;Julian P. Whitelegge

  • A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss

    Robert M. Cohen;Kavon Rezai-Zadeh;Tara M. Weitz;Altan Rentsendorj

  • Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: A link between Aβ and tau pathology

    Salvatore Oddo;Antonella Caccamo;Levina Tran;Mary P. Lambert

  • Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease

    Jun Zhou;María I Fonseca;Rakez Kayed;Irma Arias Hernández

Frequent Co-Authors

Rakez Kayed
Rakez Kayed The University of Texas Medical Branch at Galveston
Carl W. Cotman
Carl W. Cotman University of California, Irvine
Elizabeth Head
Elizabeth Head University of California, Irvine
David Eisenberg
David Eisenberg Harvard University
David H. Cribbs
David H. Cribbs University of California, Irvine
Michael R. Sawaya
Michael R. Sawaya University of California, Los Angeles
Andrea J. Tenner
Andrea J. Tenner University of California, Irvine
Duilio Cascio
Duilio Cascio University of California, Los Angeles
Frank M. LaFerla
Frank M. LaFerla University of California, Irvine
Michelle E. Ehrlich
Michelle E. Ehrlich Icahn School of Medicine at Mount Sinai

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

A background in Biology or Biochemistry opens doors to many rewarding careers and study options in the USA. Students interested in nutrition and health may consider dietitian masters programs, which prepare you for advanced roles in dietary planning and clinical nutrition. These programs often blend science coursework with practical application, setting the stage for credentialed work in healthcare and wellness fields.

For those seeking fast entry into healthcare, medical assistant classes online with financial aid provide an accessible way to gain valuable clinical skills and certification. If you're interested in career growth beyond a medical assistant role, there are also ma to lpn bridge programs online that streamline the process of becoming a Licensed Practical Nurse—an opportunity for advancement with increased responsibility and earning potential.

Students wishing for a more science-focused degree can explore online biology degree pathways. Accelerated options exist for motivated learners seeking to finish sooner and start their careers or advanced studies quickly. Whether you are looking to enter a clinical profession, research, or allied health, the flexibility of online options can help you achieve your goals in this dynamic field.

Best Scientists Citing Charles G. Glabe

Trending Scientists

Recently Published Articles