World's Best Scientists 2026 revealed!

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Biology and Biochemistry

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92
Citations
35255
World Ranking
2197
National Ranking
156

Medicine

D-Index
92
Citations
35653
World Ranking
11199
National Ranking
608

Research.com Recognitions

  • 2010 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Gynaecology and Paediatrics

Overview

Karl Welte is affiliated with the University of Tübingen in Germany. Their research spans medicine and biochemistry, genetics, and molecular biology, with a prominent focus on genetics, oncology, molecular biology, immunology, and physiology. Their work predominantly addresses blood disorders and treatments, neutropenia and cancer infections, erythrocyte function and pathophysiology, immunodeficiency and autoimmune disorders, acute myeloid leukemia research, ubiquitin and proteasome pathways, and hematological disorders and diagnostics.

Welte has contributed to various notable papers, including:

  • The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between the European Hematology Association and the EuNet-INNOCHRON COST Action (2023), published in HemaSphere
  • SRP54 mutations induce congenital neutropenia via dominant-negative effects on XBP1 splicing (2020), published in Blood
  • iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia (2021), published in Cell Stem Cell
  • NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells (2021), published in Stem Cell Research & Therapy
  • New insights into the pathomechanism of cyclic neutropenia (2020), published in Annals of the New York Academy of Sciences

Frequent co-authors collaborating with Welte include:

  • Julia Skokowa
  • Cornelia Zeidler
  • Maksim Klimiankou
  • Benjamin Dannenmann
  • Masoud Nasri

Welte publishes regularly in several scientific venues, with significant numbers of contributions in:

  • Blood
  • HemaSphere
  • Leukemia
  • Molecular Therapy
  • British Journal of Haematology

Their main fields of study encompass:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

The subfields of study Welte focuses on are:

  • Genetics
  • Oncology
  • Molecular Biology
  • Immunology
  • Physiology

The primary research topics addressed by Welte include:

  • Blood disorders and treatments
  • Neutropenia and Cancer Infections
  • Erythrocyte Function and Pathophysiology
  • Immunodeficiency and Autoimmune Disorders
  • Acute Myeloid Leukemia Research
  • Ubiquitin and proteasome pathways
  • Hematological disorders and diagnostics

In 2010, Karl Welte received recognition from the German National Academy of Sciences Leopoldina for contributions related to gynecology and paediatrics.

Best Publications

  • Use of double-stranded dna in exosomes: a novel biomarker in cancer detection

    David C. Lyden;Hector Peinado Selgas;Haiying Zhang;Basant Kumar Thakur

  • Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells

    Lawrence M. Souza;Thomas C. Boone;Janice Gabrilove;Por H. Lai

  • Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium

    J.L. Gabrilove;J.L. Gabrilove;A. Jakubowski;A. Jakubowski;H. Scher;H. Scher;C. Sternberg;C. Sternberg

  • Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group.

    Martin Schrappe;Alfred Reiter;Wolf-Dieter Ludwig;Jochen Harbott

  • Filgrastim (r-metHuG-CSF): The First 10 Years

    K Welte;J Gabrilove;MH Bronchud;E Platzer

  • Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia.

    David C. Dale;Richard E. Person;Audrey Anna Bolyard;Andrew G. Aprikyan

  • Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95

    Anja Möricke;Alfred Reiter;Martin Zimmermann;Helmut Gadner

  • Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor.

    Karl Welte;Erich Platzer;Li Lu;Janice L. Gabrilove

  • Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000

    A Möricke;M Zimmermann;A Reiter;G Henze

  • Effects of Recombinant Human Granulocyte Colony-Stimulating Factor on Neutropenia in Patients with Congenital Agranulocytosis

    Mary Ann Bonilla;Alfred P. Gillio;Mary Ruggeiro;Nancy A. Kernan

  • Recombinant human granulocyte colony-stimulating factor. Effects on hematopoiesis in normal and cyclophosphamide-treated primates.

    K. Welte;M. A. Bonilla;A. P. Gillio;T. C. Boone

  • HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

    Christoph Klein;Magda Grudzien;Giridharan Appaswamy;Manuela Germeshausen

  • Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study

    Martin Schrappe;Maria Grazia Valsecchi;Claus R. Bartram;André Schrauder

  • Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia

    Fan Dong;Russell K. Brynes;Nicola Tidow;Karl Welte

  • The incidence of leukemia and mortality from sepsis in patients with severe congenital neutropenia receiving long-term G-CSF therapy

    Philip S. Rosenberg;Blanche P. Alter;Audrey A. Bolyard;Mary Ann Bonilla

  • Severe chronic neutropenia: treatment and follow-up of patients in the Severe Chronic Neutropenia International Registry.

    David C. Dale;Tammy E. Cottle;Carol J. Fier;Audrey Anna Bolyard

  • Localized Ewing Tumor of Bone: Final Results of the Cooperative Ewing’s Sarcoma Study CESS 86

    M. Paulussen;S. Ahrens;J. Dunst;W. Winkelmann

  • Activation of human macrophages. Comparison of other cytokines with interferon-gamma.

    C F Nathan;T J Prendergast;M E Wiebe;E R Stanley

  • Diagnosis and Clinical Course of Autoimmune Neutropenia in Infancy: Analysis of 240 Cases

    Juergen Bux;Georg Behrens;Georg Behrens;Georg Behrens;Gudrun Jaeger;Gudrun Jaeger;Gudrun Jaeger;Karl Welte;Karl Welte;Karl Welte

  • Differential effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in children with severe congenital neutropenia.

    Karl Welte;Cornelia Zeidler;Alfred Reiter;Wolfgang Müller

Frequent Co-Authors

David C. Dale
David C. Dale University of Washington
Martin Stanulla
Martin Stanulla Hannover Medical School
Alfred Reiter
Alfred Reiter University of Giessen
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Laurence A. Boxer
Laurence A. Boxer University of Michigan–Ann Arbor
Lothar Kanz
Lothar Kanz University of Tübingen
Martin Schrappe
Martin Schrappe Kiel University
Martin Zimmermann
Martin Zimmermann Hannover Medical School
Brigitte Schlegelberger
Brigitte Schlegelberger Hannover Medical School
Dirk Reinhardt
Dirk Reinhardt University of Duisburg-Essen

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