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Biology and Biochemistry

D-Index
66
Citations
11869
World Ranking
8884
National Ranking
233

Overview

Ivo P. Touw is affiliated with Erasmus University Rotterdam in the Netherlands and has a robust research portfolio primarily in the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their work extensively covers Genetics, Immunology, Hematology, Molecular Biology, and Oncology subfields.

The research topics addressed by Ivo P. Touw include:

  • Blood disorders and treatments
  • Acute Myeloid Leukemia Research
  • Immunodeficiency and Autoimmune Disorders
  • Neutropenia and Cancer Infections
  • Zebrafish Biomedical Research Applications
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Hematological disorders and diagnostics

The scientist has published multiple papers in prominent journals, with recent work including:

  • The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children: A Consensus Between the European Hematology Association and the EuNet-INNOCHRON COST Action (2023) in HemaSphere
  • Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish (2021) in Blood Advances
  • RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils (2023) in Genes & Development
  • Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia (2020) in Cell Reports Medicine
  • PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations (2021) in Blood Advances

Frequent collaborators in their research include Remco M. Hoogenboezem, Emma de Pater, Emanuele Gioacchino, Eric M. Bindels, and Hans de Looper. These collaborations have contributed to a steady output of publications.

Most of Ivo P. Touw's research has been published in key venues such as Blood Advances, HemaSphere, bioRxiv (Cold Spring Harbor Laboratory), British Journal of Haematology, and Blood. Their work often intersects clinical and molecular approaches to understand blood-related diseases and immune mechanisms.

Best Publications

  • Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia

    Fan Dong;Russell K. Brynes;Nicola Tidow;Karl Welte

  • The Jak-Stat pathway in normal and perturbed hematopoiesis

    Alister C. Ward;Ivo Touw;Akihiko Yoshimura

  • Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.

    Noemi A. Zambetti;Zhen Ping;Si Chen;Keane J.G. Kenswil

  • Severe congenital neutropenias

    Julia Skokowa;David C. Dale;Ivo P. Touw;Cornelia Zeidler

  • Hematopoietic growth factors and their receptors in acute leukemia

    B Lowenberg;IP Touw

  • Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation

    Fan Dong;C. van Buitenen;K. Pouwels;Lies Hoefsloot

  • Autonomous Proliferation of Leukemic Cells in Vitro as a Determinant of Prognosis in Adult Acute Myeloid Leukemia

    B. Löwenberg;W. L. J. Van Putten;I. P. Touw;R. Delwel

  • Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia

    Fan Dong;Lies Hoefsloot;Anita Schelen;C.A. Broeders

  • Sustained Receptor Activation and Hyperproliferation in Response to Granulocyte Colony-stimulating Factor (G-CSF) in Mice with a Severe Congenital Neutropenia/Acute Myeloid Leukemia-derived Mutation in the G-CSF Receptor Gene

    Mirjam H.A. Hermans;Claudia Antonissen;Alister C. Ward;Angelique E.M. Mayen

  • Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia

    I Touw;K Pouwels;T van Agthoven;R van Gurp

  • Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts

    Rastislav Horos;Hanna IJspeert;Dagmar Pospisilova;Regine Sendtner

  • G-CSF and its receptor in myeloid malignancy.

    Renée Beekman;Ivo P. Touw

  • Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia

    Renée Beekman;Marijke G. Valkhof;Mathijs A. Sanders;Paulette M H Van Strien

  • Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia.

    F. Dong;D. C. Dale;M. A. Bonilla;M. Freedman

  • STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1).

    J P de Koning;A A Soede-Bobok;A C Ward;A M Schelen

  • Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice

    Joanna M Prasher;Astrid S Lalai;Claudia Heijmans-Antonissen;Robert E Ploemacher

  • Regulation of granulopoiesis by transcription factors and cytokine signals.

    A. C. Ward;D. M. Loeb;A. A. Soede-Bobok;I. P. Touw

  • G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth

    Quan Sheng Zhu;Ling Xia;Gordon B. Mills;Clifford A. Lowell

  • Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration.

    Alister C. Ward;Mirjam H.A. Hermans;Louise Smith;Yvette M. van Aesch

  • Interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response.

    Leo M. Budel;Ivo P. Touw;Ruud Delwel;Steven C. Clark

Frequent Co-Authors

Bob Löwenberg
Bob Löwenberg Erasmus MC
Ruud Delwel
Ruud Delwel Erasmus MC
Alister C. Ward
Alister C. Ward Deakin University
Peter J. M. Valk
Peter J. M. Valk Erasmus University Rotterdam
Lies H. Hoefsloot
Lies H. Hoefsloot Erasmus University Rotterdam
Karl Welte
Karl Welte University of Tübingen
David C. Dale
David C. Dale University of Washington
Robert J. Kreitman
Robert J. Kreitman National Cancer Institute
Steven W. J. Lamberts
Steven W. J. Lamberts Erasmus University Rotterdam
Jan Palmblad
Jan Palmblad Karolinska University Hospital

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